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79055-67-7生产厂家

79055-67-7价格

79055-67-7

79055-67-7结构式
79055-67-7结构式
  • 常用中文名:L-AP5
  • 常用英文名:L-AP5
  • CAS号:79055-67-7
  • 分子式:C5H12NO5P
  • 分子量:197.13
  • 相关类别: 信号通路 跨膜转运 iGluR
  • 发布时间:2017-01-18 17:32:18
  • 更新时间:2024-01-02 20:25:48
  • L-AP5(L-APV;L-2-氨基-5-膦酸)是NMDA拮抗剂,是D-AP5(HY-100714A)的异构体。L-AP5表现出相对较弱的氨基酸和突触阻断活性[1]。

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英文名 l-ap5
英文别名 D(-)-APV
L-AP5
[3H]-D(-)-2-Amino-5-phosphonopentanoic acid
D-2-Amino-5-phosphonovaleric acid
D-2-Amino-5-phosphopentanoic acid
L-Norvaline, 5-phosphono-
5-Phosphono-D-norvaline
D-Norvaline,5-phosphono
L-(+)-2-Amino-5-phosphonopentanoic acid
Quinolinic acid
D-AP5
D(-)-2-Amino-5-phosphonopentanoic acid
描述 L-AP5(L-APV;L-2-氨基-5-膦酸)是NMDA拮抗剂,是D-AP5(HY-100714A)的异构体。L-AP5表现出相对较弱的氨基酸和突触阻断活性[1]。
相关类别
靶点

NMDA Receptor

参考文献

[1]. Davies and Watkins (1982) Actions of D and L forms of 2-amino-5-phosphonovalerate and 2-amino-4-phosphonobutyrate in the cat spinal cord. Brain Res. 235 378  

密度 1.5±0.1 g/cm3
沸点 482.1±55.0 °C at 760 mmHg
分子式 C5H12NO5P
分子量 197.13
闪点 245.4±31.5 °C
精确质量 197.045303
PSA 130.66000
LogP -2.32
蒸汽压 0.0±2.6 mmHg at 25°C
折射率 1.536
储存条件

密闭于2-8ºC阴凉干燥环境中

稳定性

遵照规定使用和储存则不会分解。

分子结构

1、 摩尔折射率:40.21

2、 摩尔体积(m3/mol):128.9

3、 等张比容(90.2K):384.8

4、 表面张力(dyne/cm):79.4

5、 极化率(10 -24cm 3):15.94

计算化学

1、 疏水参数计算参考值(XlogP):-4

2、 氢键供体数量:1

3、 氢键受体数量:5

4、 可旋转化学键数量:3

5、 拓扑分子极性表面积(TPSA):131

6、 重原子数量:12

7、 表面电荷:-2

8、 复杂度:183

9、 同位素原子数量:0

10、 确定原子立构中心数量:1

11、 不确定原子立构中心数量:0

12、 确定化学键立构中心数量:0

13、 不确定化学键立构中心数量:0

14、 共价键单元数量:1

更多

1. 性状:无可用

2. 密度(g/mL,25/4℃):无可用

3. 相对蒸汽密度(g/mL,空气=1):无可用

4. 熔点(ºC):无可用

5. 沸点(ºC,常压):无可用

6. 沸点(ºC,5.2kPa):无可用

7. 折射率:无可用

8. 闪点(ºC):无可用

9. 比旋光度(º):无可用

10. 自燃点或引燃温度(ºC):无可用

11. 蒸气压(kPa,25ºC):无可用

12. 饱和蒸气压(kPa,60ºC):无可用

13. 燃烧热(KJ/mol):无可用

14. 临界温度(ºC):无可用

15. 临界压力(KPa):无可用

16. 油水(辛醇/水)分配系数的对数值:无可用

17. 爆炸上限(%,V/V):无可用

18. 爆炸下限(%,V/V):无可用

19. 溶解性:无可用

Name: L(+)-2-Amino-5-phosphonovaleric acid 95% (>99% e.e.) 0.25 mole EtOH Material Safety Data Sheet
Synonym: L-5-Phosphononorvaline; L-2-Amino-5-phosphonopentanoic acid; L-AP-5; 5-Phosphono-L-norvaline; L-2-Amino-5-phosphonopentanoic acid; L-2-Amino-5-phosphonovaleric acid
CAS: 79055-67-7
Section 1 - Chemical Product MSDS Name:L(+)-2-Amino-5-phosphonovaleric acid 95% (>99% e.e.) 0.25 mole EtOH Material Safety Data Sheet
Synonym:L-5-Phosphononorvaline; L-2-Amino-5-phosphonopentanoic acid; L-AP-5; 5-Phosphono-L-norvaline; L-2-Amino-5-phosphonopentanoic acid; L-2-Amino-5-phosphonovaleric acid

Section 2 - COMPOSITION, INFORMATION ON INGREDIENTS
CAS# Chemical Name content EINECS#
79055-67-7 L-(+)-2-Amino-5-phosphonovaleric acid 95 unlisted
Hazard Symbols: XI
Risk Phrases: 36/37/38

Section 3 - HAZARDS IDENTIFICATION
EMERGENCY OVERVIEW
Irritating to eyes, respiratory system and skin.
Potential Health Effects
Eye:
Causes eye irritation.
Skin:
Causes skin irritation. May be absorbed through the skin.
Ingestion:
May cause irritation of the digestive tract.
Inhalation:
May cause respiratory tract irritation.
Chronic:
No information found.

Section 4 - FIRST AID MEASURES
Eyes: In case of contact, immediately flush eyes with plenty of water for at least 15 minutes. Get medical aid.
Skin:
In case of contact, flush skin with plenty of water. Remove contaminated clothing and shoes. Get medical aid if irritation develops and persists. Wash clothing before reuse.
Ingestion:
If swallowed, do not induce vomiting unless directed to do so by medical personnel. Never give anything by mouth to an unconscious person. Get medical aid.
Inhalation:
If inhaled, remove to fresh air. If not breathing, give artificial respiration. If breathing is difficult, give oxygen. Get medical aid.
Notes to Physician:

Section 5 - FIRE FIGHTING MEASURES
General Information:
As in any fire, wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear. Combustion generates toxic fumes. Use water spray to keep fire-exposed containers cool.
Extinguishing Media:
Use water spray, dry chemical, or carbon dioxide.

Section 6 - ACCIDENTAL RELEASE MEASURES
General Information: Use proper personal protective equipment as indicated in Section 8.
Spills/Leaks:
Vacuum or sweep up material and place into a suitable disposal container. Avoid generating dusty conditions. Provide ventilation.

Section 7 - HANDLING and STORAGE
Handling:
Wash thoroughly after handling. Remove contaminated clothing and wash before reuse. Use with adequate ventilation. Minimize dust generation and accumulation. Avoid contact with eyes, skin, and clothing. Avoid breathing dust.
Storage:
Store in a tightly closed container. Store in a cool, dry, well-ventilated area away from incompatible substances.

Section 8 - EXPOSURE CONTROLS, PERSONAL PROTECTION
Engineering Controls:
Facilities storing or utilizing this material should be equipped with an eyewash facility and a safety shower. Use adequate ventilation to keep airborne concentrations low.
Exposure Limits CAS# 79055-67-7: Personal Protective Equipment Eyes: Wear appropriate protective eyeglasses or chemical safety goggles as described by OSHA's eye and face protection regulations in 29 CFR 1910.133 or European Standard EN166.
Skin:
Wear appropriate protective gloves to prevent skin exposure.
Clothing:
Wear appropriate protective clothing to prevent skin exposure.
Respirators:
Follow the OSHA respirator regulations found in 29 CFR 1910.134 or European Standard EN 149. Use a NIOSH/MSHA or European Standard EN 149 approved respirator if exposure limits are exceeded or if irritation or other symptoms are experienced.

Section 9 - PHYSICAL AND CHEMICAL PROPERTIES

Physical State: Crystalline powder
Color: white
Odor: No data
pH: Not available.
Vapor Pressure: Negligible
Viscosity: Not available.
Boiling Point: Not available.
Freezing/Melting Point: 100 - 110 deg C
Autoignition Temperature: Not available.
Flash Point: Not applicable.
Explosion Limits, lower: Not available.
Explosion Limits, upper: Not available.
Decomposition Temperature:
Solubility in water:
Specific Gravity/Density:
Molecular Formula: C5H12NO5P
Molecular Weight: 197.13

Section 10 - STABILITY AND REACTIVITY
Chemical Stability:
Stable under normal temperatures and pressures.
Conditions to Avoid:
Dust generation.
Incompatibilities with Other Materials:
Strong oxidizers.
Hazardous Decomposition Products:
Carbon monoxide, oxides of nitrogen, oxides of phosphorus, carbon dioxide.
Hazardous Polymerization: Has not been reported

Section 11 - TOXICOLOGICAL INFORMATION
RTECS#:
CAS# 79055-67-7 unlisted.
LD50/LC50:
Not available.
Carcinogenicity:
L-(+)-2-Amino-5-phosphonovaleric acid - Not listed by ACGIH, IARC, or NTP.

Section 12 - ECOLOGICAL INFORMATION


Section 13 - DISPOSAL CONSIDERATIONS
Dispose of in a manner consistent with federal, state, and local regulations.

Section 14 - TRANSPORT INFORMATION

IATA
Shipping Name: Not regulated.
Hazard Class:
UN Number:
Packing Group:
IMO
Shipping Name: Not regulated.
Hazard Class:
UN Number:
Packing Group:
RID/ADR
Shipping Name: Not regulated.
Hazard Class:
UN Number:
Packing group:

Section 15 - REGULATORY INFORMATION

European/International Regulations
European Labeling in Accordance with EC Directives
Hazard Symbols: XI
Risk Phrases:
R 36/37/38 Irritating to eyes, respiratory system
and skin.
Safety Phrases:
S 26 In case of contact with eyes, rinse immediately
with plenty of water and seek medical advice.
S 37/39 Wear suitable gloves and eye/face
protection.
WGK (Water Danger/Protection)
CAS# 79055-67-7: No information available.
Canada
None of the chemicals in this product are listed on the DSL/NDSL list.
CAS# 79055-67-7 is not listed on Canada's Ingredient Disclosure List.
US FEDERAL
TSCA
CAS# 79055-67-7 is not listed on the TSCA inventory.
It is for research and development use only.


SECTION 16 - ADDITIONAL INFORMATION
N/A

生态学数据:

该物质对环境可能有危害,对水体应给予特别注意。

危害码 (欧洲) Xi
风险声明 (欧洲) 36/37/38
安全声明 (欧洲) 26-36