312753-06-3

• 常用中文名：茚达特罗
• 常用英文名：Indacaterol
• CAS号：312753-06-3
• 分子式：C₂₄H₂₈N₂O₃
• 分子量：392.49100
• 相关类别： 生物化工 抑制剂 神经信号通路(Neuronal Signaling) Adrenergic Receptor 激动剂
• 发布时间：2018-04-27 08:00:00
• 更新时间：2024-01-02 18:22:39
• Indacaterol(Onbrez; Arcapta)是超长效β-肾上腺素受体激动剂。

名称

• 中文名: 茚达特罗
• 英文名: indacaterol
• 英文别名: Arcapta; 2(1H)-QUINOLINONE,5-[(1R)-2-[(5,6-DIETHYL-2,3-DIHYDRO-1H-INDEN-2-YL)AMINO]-1-HYDROXYETHYL]-8-HYDROXY-; 5-{(1R)-2-((5,6-Diethyl-2,3-dihydro-1H-inden-2-yl)amino)-1-hydroxyethyl}-8-hydroxyquinolin-2(1H)-one; [3H]-Indacaterol; 2(1H)-Quinolinone, 5-[(1R)-2-[(5,6-diethyl-2,3-dihydro-1H-inden-2-yl)amino]-1-hydroxyethyl]-8-hydroxy-; Indacaterol; 5-{(1R)-2-[(5,6-Diethyl-2,3-dihydro-1H-inden-2-yl)amino]-1-hydroxyethyl}-8-hydroxy-2(1H)-quinolinone; Onbrez

物化性质

• 密度: 1.27
• 分子式: C₂₄H₂₈N₂O₃
• 分子量: 392.49100
• 精确质量: 392.21000
• PSA: 85.35000
• LogP: 3.53980
• 储存条件: 2-8°C

生物活性

• 描述: Indacaterol(Onbrez; Arcapta)是超长效β-肾上腺素受体激动剂。
• 相关类别:
  信号通路 >> G 蛋白偶联受体/G 蛋白 >> 肾上腺素能受体
  研究领域 >> 神经疾病
• 参考文献:

  [1]. Battram, C., et al., In vitro and in vivo pharmacological characterization of 5-[(R)-2-(5,6-diethyl-indan-2-ylamino)-1-hydroxy-ethyl]-8-hydroxy-1H-quinolin-2-o ne (indacaterol), a novel inhaled beta(2) adrenoceptor agonist with a 24-h duration of action.

  [2]. Sturton, R.G., et al., Pharmacological characterization of indacaterol, a novel once daily inhaled 2 adrenoceptor agonist, on small airways in human and rat precision-cut lung slices. J Pharmacol Exp Ther, 2008. 324(1): p. 270-5.

合成路线

435273-75-9 ~84% 312753-06-3

文献：Baur, Francois; Beattie, David; Beer, David; Bentley, David; Bradley, Michelle; Bruce, Ian; Charlton, Steven J.; Cuenoud, Bernard; Ernst, Roland; Fairhurst, Robin A.; Faller, Bernard; Farr, David; Keller, Thomas; Fozard, John R.; Fullerton, Joe; Garman, Sheila; Hatto, Julia; Hayden, Claire; He, Handan; Howes, Colin; Janus, Diana; Jiang, Zhengjin; Lewis, Christine; Loeuillet-Ritzler, Frederique; Moser, Heinz; Reilly, John; Steward, Alan; Sykes, David; Tedaldi, Lauren; Trifilieff, Alexandre; Tweed, Morris; Watson, Simon; Wissler, Elke; Wyss, Daniel Journal of Medicinal Chemistry, 2010 , vol. 53, # 9 p. 3675 - 3684

312753-70-1 ~% 312753-06-3

文献：WO2014/44288 A1, ; WO2014/44566 A1, ;

530084-79-8 ~% 312753-06-3

文献：WO2014/44288 A1, ; WO2014/44566 A1, ;

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