129-18-0

• 常用中文名：保泰松钠
• 常用英文名：phenylbutazone sodium
• CAS号：129-18-0
• 分子式：C₁₉H₁₉N₂NaO₂
• 分子量：330.356
• 相关类别： 原料药 解热镇痛药 抗痛风药
• 发布时间：2018-06-30 12:09:23
• 更新时间：2024-01-02 12:56:38
• 【用途一】
  解热镇痛药，用于治疗风湿性和类风湿性关节炎及痛风等

名称

• 中文名: 保泰松钠
• 英文名: Sodium butazolidine
• 中文别名: 4-丁基-1,2-二苯基-3,5-吡唑烷二酮钠盐
• 英文别名: PHENYLBUTAZONE SODIUM; 3,5-dioxo-1,2-diphenyl-4-n-butylpyrazolidinsodium; 4-BUTYL-1,2-DIPHENYL-3,5-PYRAZOLIDINEDIONE SODIUM; Einecs 204-935-7; diphenyldioxobutylpyrazolidine-butazolidine-sodium; Phenylbutazone sodium salt; PHENYL BUTAZONE SODIUM SALT; sodiumphenylbutazone; MFCD01749404; Sodium 4-butyl-3,5-dioxo-1,2-diphenylpyrazolidin-4-ide; UNII:189M850I32; butazolidinesodium

物化性质

• 密度: 1.063 g/mL at 25 °C(lit.)
• 沸点: 113 °C27 mm Hg(lit.)
• 分子式: C₁₉H₁₉N₂NaO₂
• 分子量: 330.356
• 闪点: 95 °C
• 精确质量: 330.134430
• PSA: 49.99000
• LogP: 4.11460
• 折射率: n20/D 1.516(lit.)
• 储存条件: 库房通风低温干燥,与食品原料类分开存放

毒性和生态

毒理学数据: 口服-小鼠 LD50: 476 毫克/公斤; 腹腔-大鼠 LD50: 169 毫克/公斤。 CHEMICAL IDENTIFICATION RTECS NUMBER : UQ8300000 CHEMICAL NAME : 3,5-Pyrazolidinedione, 4-butyl-1,2-diphenyl-, monosodium salt CAS REGISTRY NUMBER : 129-18-0 LAST UPDATED : 199012 DATA ITEMS CITED : 10 MOLECULAR FORMULA : C19-H20-N2-O2.Na MOLECULAR WEIGHT : 331.40 WISWESSER LINE NOTATION : T5VNNV EHJ BR& CR& E4 &-NA- HEALTH HAZARD DATA ACUTE TOXICITY DATA TYPE OF TEST : LDLo - Lowest published lethal dose ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Human - woman DOSE/DURATION : 16 mg/kg/D TOXIC EFFECTS : Lungs, Thorax, or Respiration - structural or functional change in trachea or bronchi Blood - agranulocytosis Skin and Appendages - dermatitis, other (after systemic exposure) TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 855 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Subcutaneous SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 310 mg/kg TOXIC EFFECTS : Behavioral - somnolence (general depressed activity) TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 113 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 476 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 169 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Subcutaneous SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 257 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 94 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Rodent - rabbit DOSE/DURATION : 146 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value MUTATION DATA TYPE OF TEST : Mutation test systems - not otherwise specified TEST SYSTEM : Human Lymphocyte DOSE/DURATION : 2160 umol/L REFERENCE : HUMAA7 Humangenetik. (Heidelberg, Fed. Rep. Ger.) V.1-30, 1964-75. For publisher information, see HUGEDQ. Volume(issue)/page/year: 12,330,1971

安全

• 危害码 (欧洲): C
• 风险声明 (欧洲): R36/37/38:Irritating to eyes, respiratory system and skin .
• 安全声明 (欧洲): S26-S36
• 海关编码: 2934100090

海关

海关编码	2934100090
中文概述	2934100090. 结构上含有一个非稠合噻唑环的化合物(不论是否氢化). 增值税率:17.0%. 退税率:9.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:20.0%
申报要素	品名, 成分含量, 用途
Summary	2934100090 other compounds containing an unfused thiazole ring (whether or not hydrogenated) in the structure VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:20.0%