7081-38-1

7081-38-1结构式

常用中文名：羟基保泰松
常用英文名：Oxyphenbutazone monohydrate
CAS号：7081-38-1
分子式：C₁₉H₂₂N₂O₄
分子量：342.38900
相关类别：原料药解热镇痛药解热止痛药
发布时间：2018-08-12 18:24:30
更新时间：2024-01-02 16:28:32
一水合氧苯丁酮是苯丁酮(HY-B0230)的代谢物,具有抗炎作用。一水合氧苯丁酮是一种口服活性非选择性COX抑制剂。一水合氧苯丁酮选择性地杀死非复制性结核分枝杆菌[1][2]。

中文名	羟基保泰松
英文名	oxyphenbutazone hydrate
中文别名	羟保泰松
英文别名	oxyphenbutazon monohydrate OXYPHENBUTAZONE HYDRATE OXYPHENBUTAZONE MONOHYDRATE OXYPHENYL BUTAZONE MONOHYDRATE Unii-H806S4B3ns

描述	一水合氧苯丁酮是苯丁酮(HY-B0230)的代谢物,具有抗炎作用。一水合氧苯丁酮是一种口服活性非选择性COX抑制剂。一水合氧苯丁酮选择性地杀死非复制性结核分枝杆菌[1][2]。
相关类别	研究领域 >> 感染研究领域 >> 炎症/免疫信号通路 >> 免疫及炎症 >> COX 信号通路 >> 抗感染 >> 细菌
靶点	COX, Bacteria[1][2]
体外研究	氧苯丁酮增强甲氨蝶呤(MTX)(HY-14519)在Hep3B细胞中的抗癌效率[1]。氧苯丁酮(2.5-7.5µM；48小时)与(MTX,0.25-1.0µM)共同处理显示出对Hep3B细胞的潜在细胞毒性[1]。氧苯丁酮对肝细胞具有修复作用[1]。细胞活力测定[1]细胞株：Hep3B细胞浓度：2.5µM、5µM和7.5µM培养时间：48小时结果：增强了MTX的细胞毒性。
体内研究	当与MTX(5.0或2.5 mg/kg/week；i.p.)联合治疗时,氧苯丁酮(70 mg/kg/we周；p.o.；分两次服用；持续13周)具有潜在的抗癌活性[1]。动物模型：Wistar系白化雄性大鼠(5-6周；150-220 g)[1]剂量：70 mg/kg/周(与MTX 5.0或2.5 mg/kg/星期共同治疗)给药：PO；一周一次分两次服用；结果：与甲氨蝶呤联合治疗大鼠,发挥了潜在的抗癌活性。
参考文献	[1]. Saleem S, et al. Oxyphenbutazone promotes cytotoxicity in rats and Hep3B cellsvia suppression of PGE2 and deactivation of Wnt/β-catenin signaling pathway. Mol Cell Biochem. 2018 Jul;444(1-2):187-196. [2]. Gold B, et al. Nonsteroidal anti-inflammatory drug sensitizes Mycobacterium tuberculosis to endogenous and exogenous antimicrobials. Proc Natl Acad Sci U S A. 2012 Oct 2;109(40):16004-11.

沸点	485.6ºC at 760 mmHg
熔点	96°; mp 124-125°
分子式	C₁₉H₂₂N₂O₄
分子量	342.38900
闪点	247.5ºC
精确质量	342.15800
PSA	70.08000
LogP	3.55910
储存条件	2-8°C

Version 1.2
Regulation (EC) No 1907/2006

1 - Product and Company Information

Product NameOXYPHENBUTAZONE HYDRATE

2 - Hazards Identification

SPECIAL INDICATION OF HAZARDS TO HUMANS AND THE ENVIRONMENT

Harmful if swallowed. Irritating to eyes and skin. Limited
evidence of a carcinogenic effect. May cause sensitization by
inhalation and skin contact.

3 - Composition/Information on Ingredients

Product NameCAS #EC noAnnex I
Index Number
OXYPHENBUTAZONE HYDRATE7081-38-1 NoneNone
FormulaC19H20N2O3
Molecular Weight 324,4000 AMU

4 - First Aid Measures

AFTER INHALATION
If inhaled, remove to fresh air. If not breathing give
artificial respiration. If breathing is difficult, give oxygen.
AFTER INGESTION
If swallowed, wash out mouth with water provided person is
conscious. Call a physician.

5 - Fire Fighting Measures

EXTINGUISHING MEDIA
Suitable: Water spray. Appropriate foam.
SPECIAL PROTECTIVE EQUIPMENT FOR FIREFIGHTERS
Wear self-contained breathing apparatus and protective clothing
to prevent contact with skin and eyes.

6 - Accidental Release Measures
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PROCEDURE(S) OF PERSONAL PRECAUTION(S)
Wear self-contained breathing apparatus, rubber boots, and heavy
rubber gloves.
METHODS FOR CLEANING UP
Sweep up, place in a bag and hold for waste disposal. Avoid
raising dust. Ventilate area and wash spill site after material
pickup is complete.

7 - Handling and Storage

HANDLING
Directions for Safe Handling: Do not breathe dust. Do not get in
eyes, on skin, on clothing. Avoid prolonged or repeated exposure.
STORAGE
Conditions of Storage: Keep tightly closed. Store in a cool dry
place.
Store at 2-8°C

8 - Exposure Controls / Personal Protection

ENGINEERING CONTROLS
Safety shower and eye bath. Mechanical exhaust required.
GENERAL HYGIENE MEASURES
Wash thoroughly after handling. Wash contaminated clothing before
reuse.
PERSONAL PROTECTIVE EQUIPMENT
Special Protective Measures: Wear appropriate government approved
respirator, chemical-resistant gloves, safety goggles, other
protective clothing.

9 - Physical and Chemical Properties

AppearancePhysical State: Solid
PropertyValueAt Temperature or Pressure
pHN/A
BP/BP RangeN/A
MP/MP RangeN/A
Flash PointN/A
FlammabilityN/A
Autoignition TempN/A
Oxidizing PropertiesN/A
Explosive PropertiesN/A
Explosion LimitsN/A
Vapor PressureN/A
Partition CoefficientN/A
ViscosityN/A
Vapor DensityN/A
Saturated Vapor Conc.N/A
Evaporation RateN/A
Bulk DensityN/A
Decomposition Temp.N/A
Solvent ContentN/A
Water ContentN/A
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Surface TensionN/A
ConductivityN/A
Miscellaneous DataN/A
SolubilityN/A

10 - Stability and Reactivity

STABILITY
Stable: Stable.
HAZARDOUS DECOMPOSITION PRODUCTS
Hazardous Decomposition Products: Carbon monoxide, carbon dioxide,
and nitrogen oxides.
HAZARDOUS POLYMERIZATION
Hazardous Polymerization: Will not occur

11 - Toxicological Information

SENSITIZATION
Sensitization: May cause allergic reaction.
SIGNS AND SYMPTOMS OF EXPOSURE
To the best of our knowledge, the chemical, physical, and
toxicological properties have not been thoroughly investigated.
Fever, sore throat, lesions in the mouth, symptoms of anemia,
unusual bleeding or bruising, dyspepsia, epigastric pain, black
or tarry stools or other evidence of intestinal ulceration, skin
rashes, significant weight gain, edema, optic neuritis,
superficial ulceration of the cornea, conjunctivitis, blurred
vision, retinal hemorrhage, toxic amblyopia, retina detachment,
agranulocytosis, aplastic anemia, liver and kidney damage.
Stomach pains, vomiting, diarrhea. Exposure can cause:
ROUTE OF EXPOSURE
Skin Absorption: May be harmful if absorbed through the skin.
Inhalation: May be harmful if inhaled. Material may be
irritating to mucous membranes and upper respiratory tract.
Ingestion: Harmful if swallowed.
Multiple Routes: Causes eye and skin irritation.
TARGET ORGAN INFORMATION
Thyroid. Liver. Kidneys. Bone marrow. G.I. System. Blood.

12 - Ecological Information

No data available.

13 - Disposal Considerations

SUBSTANCE DISPOSAL
Dissolve or mix the material with a combustible solvent and burn
in a chemical incinerator equipped with an afterburner and
scrubber. Observe all federal, state, and local environmental
regulations.

14 - Transport Information

RID/ADR
Non-hazardous for road transport.
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IMDG
Non-hazardous for sea transport.
IATA
Non-hazardous for air transport.

15 - Regulatory Information

CLASSIFICATION AND LABELING ACCORDING TO EU DIRECTIVES
INDICATION OF DANGER: Xn
Harmful.
R-PHRASES: 22-36/38-40-42/43
Harmful if swallowed. Irritating to eyes and skin. Limited
evidence of a carcinogenic effect. May cause sensitization by
inhalation and skin contact.
S-PHRASES: 22-26-36
Do not breathe dust. In case of contact with eyes, rinse
immediately with plenty of water and seek medical advice. Wear
suitable protective clothing.
Caution: Substance not yet fully tested (EU).
COUNTRY SPECIFIC INFORMATION
Germany
WGK: 3
Self-Classification

16 - Other Information

DISCLAIMER
For R&D or manufacturing use. Not for prescription compound or
other uses.
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SECTION 16 - ADDITIONAL INFORMATION
N/A

危害码 (欧洲)	Xn
风险声明 (欧洲)	22-36/38-40-42/43
安全声明 (欧洲)	22-26-36

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