191114-48-4

• 常用中文名：泰利霉素
• 常用英文名：Telithromycin
• CAS号：191114-48-4
• 分子式：C₄₃H₆₅N₅O₁₀
• 分子量：812.004
• 相关类别： 原料药 抗生素类药物 大环内酯类药
• 发布时间：2018-10-03 17:22:32
• 更新时间：2024-01-06 12:36:56
• Telithromycin(HMR3647)为可作用于社区获得性肺炎的抗生素。

名称

• 中文名: 泰利霉素
• 英文名: Telithromycin
• 中文别名: 红霉酮(特利霉素)
• 英文别名: 2H-Oxacyclotetradecino[4,3-d]oxazole-2,6,8,14(1H,7H,9H)-tetrone, 4-ethyloctahydro-11-methoxy-3a,7,9,11,13,15-hexamethyl-1-[4-[4-(3-pyridinyl)-1H-imidazol-1-yl]butyl]-10-[[3,4,6-trideoxy-3-(dimethylami ;no)-β-D-xylo-hexopyranosyl]oxy]-, (3aS,4R,7R,9R,10R,11R,13R,15R,15aR)-; KETEK; (3aS,4R,7R,9R,10R,11R,13R,15R,15aR)-4-ethyl-11-methoxy-3a,7,9,11,13,15-hexamethyl-2,6,8,14-tetraoxo-1-[4-(4-pyridin-3-yl-1H-imidazol-1-yl)butyl]tetradecahydro-2H-oxacyclotetradecino[4,3-d][1,3]oxazol-10-yl 3,4,6-trideoxy-3-(dimethylamino)-β-D-xylo-hexopyranoside; (3aS,4R,7R,9R,10R,11R,13R,15R,15aR)-10-{[(2S,3R,4S,6R)-4-(Dimethylamino)-3-hydroxy-6-methyltetrahydro-2H-pyran-2-yl]oxy}-4-ethyl-11-methoxy-3a,7,9,11,13,15-hexamethyl-1-[4-(4-pyridin-3-yl-1H-imidazol-1-yl)butyl]octahydro-2H-oxacyclotetradecino[4,3-d][1,3]oxazol-2,6,8,14(1H,7H,9H)-tetron; (3aS,4R,7R,9R,10R,11R,13R,15R,15aR)-4-Ethyl-11-methoxy-3a,7,9,11,13,15-hexamethyl-2,6,8,14-tetraoxo-1-{4-[4-(3-pyridinyl)-1H-imidazol-1-yl]butyl}tetradecahydro-2H-oxacyclotetradecino[4,3-d][1,3]oxazol ;-10-yl 3,4,6-trideoxy-3-(dimethylamino)-β-D-xylo-hexopyranoside; Telithromycin; (3aS,4R,7R,9R,10R,11R,13R,15R,15aR)-4-Ethyl-11-methoxy-3a,7,9,11,13,15-hexamethyl-2,6,8,14-tetraoxo-1-{4-[4-(pyridin-3-yl)-1H-imidazol-1-yl]butyl}tetradecahydro-2H-oxacyclotetradecino[4,3-d][1,3]oxazol-10-yl 3,4,6-trideoxy-3-(dimethylamino)-β-D-xylo-hexopyranoside; (3aS,4R,7R,9R,10R,11R,13R,15R,15aR)-10-{[(2S,3R,4S,6R)-4-(diméthylamino)-3-hydroxy-6-méthyltétrahydro-2H-pyran-2-yl]oxy}-4-éthyl-11-méthoxy-3a,7,9,11,13,15-hexaméthyl-1-[4-(4-pyridin-3-yl-1H-imidazol-1-yl)butyl]octahydro-2H-oxacyclotétradécino[4,3-d][1,3]oxazole-2,6,8,14(1H,7H,9H)-tétrone; (1R,2R,4R,6S,7R,8R,10R,13R,14S)-7-[(2S,3R,4S,6R)-4-Dimethylamino-3-hydroxy-6-methyloxan-2-yl]oxy-13-ethyl-6-methoxy-2,4,6,8,10,14-hexamethyl-17-[4-(4-pyridin-3-ylimidazol-1-yl)butyl]-12,15-dioxa-17-azabicyclo[12.3.0]heptadecane-3,9,11,16-tetrone; (3aS,4R,7R,9R,10R,11R,13R,15R,15aR)-10-{[(2S,3R,4S,6R)-4-(dimethylamino)-3-hydroxy-6-methyltetrahydro-2H-pyran-2-yl]oxy}-4-ethyl-11-methoxy-3a,7,9,11,13,15-hexamethyl-1-[4-(4-pyridin-3-yl-1H-imidazol-1-yl)butyl]octahydro-2H-oxacyclotetradecino[4,3-d][1,3]oxazole-2,6,8,14(1H,7H,9H)-tetrone; 2H-oxacyclotetradecino[4,3-d]oxazole-2,6,8,14(1H,7H,9H)-tetrone, 4-ethyloctahydro-11-methoxy-3a,7,9,11,13,15-hexamethyl-1-[4-[4-(3-pyridinyl)-1H-imidazol-1-yl]butyl]-10-[[3,4,6-trideoxy-3-(dimethylamino)-β-D-xylo-hexopyranosyl]oxy]-, (3aS,4R,7R,9R,10R,11R,13R,15R,15aR)-; MFCD04117983; 3-De((2,6-dideoxy-3-C-methyl-3-O-methyl-a-L-ribo-hexopyranosyl)oxy)-11,12-dideoxy-6-O-methyl-3-oxo-12,11-(oxycarbonyl((4-(4-(3-pyridinyl)-1H-imidazol-1-yl)butyl)imino))erythromycin

物化性质

• 密度: 1.3±0.1 g/cm3
• 沸点: 966.2±65.0 °C at 760 mmHg
• 熔点: 176-188ºC
• 分子式: C₄₃H₆₅N₅O₁₀
• 分子量: 812.004
• 闪点: 538.2±34.3 °C
• 精确质量: 811.473145
• PSA: 171.85000
• LogP: 4.52
• 蒸汽压: 0.0±0.3 mmHg at 25°C
• 折射率: 1.589
• 储存条件: -20?C Freezer

生物活性

• 描述: Telithromycin(HMR3647)为可作用于社区获得性肺炎的抗生素。
• 相关类别:
  信号通路 >> 抗感染 >> 细菌
  研究领域 >> 感染
• 参考文献:

  [1]. http://en.wikipedia.org/wiki/Telithromycin

安全

• 危害码 (欧洲): Xi
• 风险声明 (欧洲): R36/37/38
• 安全声明 (欧洲): 26-36

合成路线

1001326-77-7 ~99% 191114-48-4

文献：ALEMBIC LIMITED Patent: US2008/51352 A1, 2008 ; Location in patent: Page/Page column 14 ;

306770-60-5 ~99% 191114-48-4

文献：ALEMBIC LIMITED Patent: WO2008/23383 A1, 2008 ; Location in patent: Page/Page column 22 ;

306770-59-2 ~% 191114-48-4

文献：WO2005/105821 A2, ; Page/Page column 22 ;

160145-83-5 173838-63-6 ~49% 191114-48-4

文献：Denis, Alexis; Agouridas, Constantin; Auger, Jean-Michel; Benedetti, Yannick; Bonnefoy, Alain; Bretin, Francois; Chantot, Jean-Francois; Dussarat, Arlette; Fromentin, Claude; Gouin D'Ambrieres, Solange; Lachaud, Sylvette; Laurin, Patrick; Le Martret, Odile; Loyau, Veronique; Tessot, Nicole; Pejac, Jean-Marie; Perron, Sebastien Bioorganic and Medicinal Chemistry Letters, 1999 , vol. 9, # 21 p. 3075 - 3080

51746-85-1 ~% 191114-48-4

文献：Bioorganic and Medicinal Chemistry Letters, , vol. 9, # 21 p. 3075 - 3080

173838-67-0 ~% 191114-48-4

文献：Bioorganic and Medicinal Chemistry Letters, , vol. 9, # 21 p. 3075 - 3080

152235-55-7 ~% 191114-48-4

文献：Journal of Chemical Research, , vol. 37, # 2 p. 107 - 109

81103-11-9 ~% 191114-48-4

文献：Journal of Chemical Research, , vol. 37, # 2 p. 107 - 109

152235-09-1 ~% 191114-48-4

文献：Journal of Chemical Research, , vol. 37, # 2 p. 107 - 109

上下游产品

上游产品  7
1001326-77-7 160145-83-5 173838-63-6 51746-85-1
173838-67-0 152235-55-7 81103-11-9
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