中文名 | 瓜子金皂苷XXXI |
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英文名 | onjisaponin F |
英文别名 |
Polygalasaponin XXXI
β-D-Galactopyranose, O-α-L-arabinopyranosyl-(1->3)-O-α-D-xylopyranosyl-(1->4)-O-6-deoxy-3-O-[(2S,3R,4R)-tetrahydro-3,4-dihydroxy-4-(hydroxymethyl)-2-furanyl]-α-L-mannopyranosyl-(1->2)-6 -deoxy-1-O-[(2β,3β)-3-(β-D-glucopyranosyloxy)-2,24,27-trihydroxy-24,28-dioxoolean-12-en-28-yl]-4-O-[(2E)-1-oxo-3-(3,4,5-trimethoxyphenyl)-2-propen-1-yl]- α-L-Arabinopyranosyl-(1->3)-α-D-xylopyranosyl-(1->4)-6-deoxy-3-O-[(2S,3R,4R)-3,4-dihydroxy-4-(hydroxymethyl)tetrahydro-2-furanyl]-α-L-mannopyranosyl-(1->2)-6-deoxy-1-O-[(2β,3β)-3-(be ta-D-glucopyranosyloxy)-2,24,27-trihydroxy-24,28-dioxoolean-12-en-28-yl]-4-O-[(2E)-3-(3,4,5-trimethoxyphenyl)-2-propenoyl]-β-D-galactopyranose |
描述 | Polygalasaponin XXXI (Onjisaponin F) 是鼻内注射流感 HA 疫苗的有效佐剂,可保护流感病毒感染 |
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相关类别 | |
体外研究 | polyglasaponinxxxi(Onjisaponin F)在鼻腔冲洗液中也能提高抗HA-IgA和IgG-Ab滴度,而Onjisaponin E和Onjisaponin E仅显著提高抗HA-IgA抗体滴度。多聚糖脂蛋白XXXI可诱导对流感病毒鼻腔感染的保护性免疫[1]。远志皂苷XXXI(Onjisaponin F)(1或10µg/mL)也诱导大鼠基底前脑细胞中ChAT mRNA水平[2]。 |
体内研究 | 鼻内接种多聚糖脂蛋白XXXI(Onjisaponin F)抑制小鼠适应型流感病毒A/PR/8/34在感染小鼠支气管肺泡灌洗液中的增殖[1]。 |
参考文献 |
密度 | 1.5±0.1 g/cm3 |
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分子式 | C75H112O36 |
分子量 | 1589.670 |
精确质量 | 1588.693359 |
PSA | 542.80000 |
LogP | 4.95 |
折射率 | 1.651 |
储存条件 | 2-8°C,保存于惰性气体中 |