35604-67-2

• 常用中文名：2-[(2-乙氧基苯氧基)甲基]吗啉盐酸盐
• 常用英文名：2-[(2-ethoxyphenoxy)methyl]morpholine hydrochloride
• CAS号：35604-67-2
• 分子式：C₁₃H₂₀ClNO₃
• 分子量：273.76
• 相关类别： 研究领域 神经疾病
• 发布时间：2018-10-06 19:16:20
• 更新时间：2024-01-11 16:25:30
• Viloxazine hydrochloride 是 Viloxazine (HY-W380450) 的非活性异构体,可作为实验中的对照化合物。Viloxazine (Viloxazin) 是一种去甲肾上腺素重摄取 (norepinephrine reuptake) 抑制剂,也是有效的 5-HT2C 激动剂和 5-HT2B 拮抗剂,对 5-HT2C 的 EC50 为 32 μM,对 5-HT2B 的 IC50 为 27 μM。Viloxazine 的作用机制主要涉及血清素能和去甲肾上腺素能通路。Viloxazine 可用于抗抑郁研究。

名称

• 中文名: 2-[(2-乙氧基苯氧基)甲基]吗啉盐酸盐
• 英文名: 2-[(2-ethoxyphenoxy)methyl]morpholine,hydrochloride
• 中文别名: 消旋盐酸维洛沙秦异构体; 盐酸维洛沙秦
• 英文别名: Emovit; Viloxacina clorhidrato [Spanish]; EINECS 252-638-6; Viloxazine HCl; Viloxazine hydrochloride; Vivalan; 2-[(2-Ethoxyphenoxy)-methyl]morpholine hydrochloride; Vicilan

物化性质

• 密度: 1.061g/cm3
• 沸点: 350.5ºC at 760mmHg
• 分子式: C₁₃H₂₀ClNO₃
• 分子量: 273.76
• 闪点: 144.3ºC
• 精确质量: 273.11300
• PSA: 39.72000
• LogP: 2.58330

生物活性

• 描述: Viloxazine hydrochloride 是 Viloxazine (HY-W380450) 的非活性异构体,可作为实验中的对照化合物。Viloxazine (Viloxazin) 是一种去甲肾上腺素重摄取 (norepinephrine reuptake) 抑制剂,也是有效的 5-HT2C 激动剂和 5-HT2B 拮抗剂,对 5-HT2C 的 EC50 为 32 μM,对 5-HT2B 的 IC50 为 27 μM。Viloxazine 的作用机制主要涉及血清素能和去甲肾上腺素能通路。Viloxazine 可用于抗抑郁研究。
• 相关类别:
  信号通路 >> 其他 >> 其他
  研究领域 >> 神经疾病
• 参考文献:

  [1]. Yu C, et al. New Insights into the Mechanism of Action of Viloxazine: Serotonin and Norepinephrine Modulating Properties. J Exp Pharmacol. 2020 Aug 25;12:285-300.

  [2]. Pinder RM, et al. Viloxazine: a review of its pharmacological properties and therapeutic efficacy in depressive illness. Drugs. 1977 Jun;13(6):401-21.

毒性和生态

CHEMICAL IDENTIFICATION RTECS NUMBER : QE3950000 CHEMICAL NAME : Morpholine, 2-((2-ethoxyphenoxy)methyl)-, hydrochloride CAS REGISTRY NUMBER : 35604-67-2 LAST UPDATED : 199209 DATA ITEMS CITED : 9 MOLECULAR FORMULA : C13-H19-N-O3.Cl-H MOLECULAR WEIGHT : 273.79 WISWESSER LINE NOTATION : T6M DOTJ C1OR BO2 &GH HEALTH HAZARD DATA ACUTE TOXICITY DATA TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Human DOSE/DURATION : 25 mg/kg/6D TOXIC EFFECTS : Behavioral - hallucinations, distorted perceptions Behavioral - convulsions or effect on seizure threshold REFERENCE : BMJOAE British Medical Journal. (British Medical Assoc., BMA House, Tavistock Sq., London WC1H 9JR, UK) V.1- 1857- Volume(issue)/page/year: 2,96,1977 TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Human - woman DOSE/DURATION : 30 mg/kg TOXIC EFFECTS : Sense Organs and Special Senses (Eye) - mydriasis (pupillary dilation) Behavioral - sleep REFERENCE : JIMRBV Journal of International Medical Research. (Cambridge Medical Pub. Ltd., 435/437 Wellingborough Rd., Northampton, NN1 4EZ, UK) V.1- 1972- Volume(issue)/page/year: 4,83,1976 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 2 gm/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : JIMRBV Journal of International Medical Research. (Cambridge Medical Pub. Ltd., 435/437 Wellingborough Rd., Northampton, NN1 4EZ, UK) V.1- 1972- Volume(issue)/page/year: 4,83,1976 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 162 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : FRPSAX Farmaco, Edizione Scientifica. (Casella Postale 227, 27100 Pavia, Italy) V.8-43 1953-88 For publisher information, see FRMCE8 Volume(issue)/page/year: 35,812,1980 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 60 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : JIMRBV Journal of International Medical Research. (Cambridge Medical Pub. Ltd., 435/437 Wellingborough Rd., Northampton, NN1 4EZ, UK) V.1- 1972- Volume(issue)/page/year: 4,83,1976 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 480 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : DDREDK Drug Development Research. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.1- 1981- Volume(issue)/page/year: 22,385,1991 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 162 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : FRPSAX Farmaco, Edizione Scientifica. (Casella Postale 227, 27100 Pavia, Italy) V.8-43 1953-88 For publisher information, see FRMCE8 Volume(issue)/page/year: 35,812,1980 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 60 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : JIMRBV Journal of International Medical Research. (Cambridge Medical Pub. Ltd., 435/437 Wellingborough Rd., Northampton, NN1 4EZ, UK) V.1- 1972- Volume(issue)/page/year: 4,83,1976 *** REVIEWS *** TOXICOLOGY REVIEW DRUGAY Drugs. International Journal of Current Therapeutics and Applied Pharmacology Reviews. (ADIS Press International Inc., Suite B-30, Oxford Ct. Business Center, 582 Middletown Blvd., Langhorne, PA 19047) V.1- 1971- Volume(issue)/page/year: 13,401,1977

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海关编码	2934999090
中文概述	2934999090. 其他杂环化合物. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:20.0%
申报要素	品名, 成分含量, 用途
Summary	2934999090. other heterocyclic compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%