1133432-46-8

• 常用中文名：GDC-0834外消旋
• 常用英文名：GDC-0834 (RaceMate)
• CAS号：1133432-46-8
• 分子式：C₃₃H₃₆N₆O₃S
• 分子量：596.742
• 相关类别： 信号通路 蛋白酪氨酸激酶 BTK
• 发布时间：2018-02-22 00:45:05
• 更新时间：2024-01-09 11:38:29
• GDC-0834 Racemate是GDC-0834的外消旋体形式。

名称

• 中文名: GDC-0834外消旋
• 英文名: GDC-0834 Racemate
• 英文别名: Benzo[b]thiophene-2-carboxamide, N-[3-[6-[[4-(1,4-dimethyl-3-oxo-2-piperazinyl)phenyl]amino]-4,5-dihydro-4-methyl-5-oxo-2-pyrazinyl]-2-methylphenyl]-4,5,6,7-tetrahydro-; N-[3-(6-{[4-(1,4-Dimethyl-3-oxo-2-piperazinyl)phenyl]amino}-4-methyl-5-oxo-4,5-dihydro-2-pyrazinyl)-2-methylphenyl]-4,5,6,7-tetrahydro-1-benzothiophene-2-carboxamide; GDC-0834 (Racemate)

物化性质

• 密度: 1.4±0.1 g/cm3
• 分子式: C₃₃H₃₆N₆O₃S
• 分子量: 596.742
• 精确质量: 596.256958
• LogP: 3.68
• 折射率: 1.697
• 储存条件: 2-8℃

生物活性

• 描述: GDC-0834 Racemate是GDC-0834的外消旋体形式。
• 相关类别:
  信号通路 >> 蛋白酪氨酸激酶 >> BTK
  研究领域 >> 炎症/免疫
• 参考文献:

  [1]. Liu L, et al. Antiarthritis effect of a novel Bruton's tyrosine kinase (BTK) inhibitor in rat collagen-induced arthritis and mechanism-based pharmacokinetic/pharmacodynamic modeling: relationships between inhibition of BTK phosphorylation and efficacy. J Pharmacol Exp Ther. 2011 Jul;338(1):154-63.

  [2]. Liu L, et al. Significant species difference in amide hydrolysis of GDC-0834, a novel potent and selective Bruton's tyrosine kinase inhibitor. Drug Metab Dispos. 2011 Oct;39(10):1840-9.