41365-32-6

• 常用中文名：3′-甲氧基蓟黄素
• 常用英文名：Cirsilineol
• CAS号：41365-32-6
• 分子式：C₁₈H₁₆O₇
• 分子量：344.31500
• 相关类别： 分析化学 分析试剂 离子色谱试剂
• 发布时间：2018-09-21 18:07:53
• 更新时间：2024-01-02 11:12:57
• Cirsilineol是一种天然黄酮化合物,可选择性抑制肠CD4+T细胞中的IFN-γ/STAT1/T-bet信号。西西林醇具有强大的免疫抑制和抗肿瘤特性。西西林醇显著改善三硝基苯磺酸(TNBS)诱导的小鼠T细胞介导的实验性结肠炎[1]。

名称

• 中文名: 甲基条叶蓟素
• 英文名: cirsilineol
• 英文别名: 4',5-Dihydroxy-3',6,7-trimethoxyflavone; 5-hydroxy-2-(4-hydroxy-3-methoxyphenyl)-6,7-dimethoxychromen-4-one; Cirsilineol

物化性质

• 密度: 1.387g/cm3
• 沸点: 585ºC at 760 mmHg
• 分子式: C₁₈H₁₆O₇
• 分子量: 344.31500
• 闪点: 215.2ºC
• 精确质量: 344.09000
• PSA: 98.36000
• LogP: 2.89700
• 外观性状: 固体
• 折射率: 1.627
• 储存条件: ?20°C

生物活性

• 描述: Cirsilineol是一种天然黄酮化合物,可选择性抑制肠CD4+T细胞中的IFN-γ/STAT1/T-bet信号。西西林醇具有强大的免疫抑制和抗肿瘤特性。西西林醇显著改善三硝基苯磺酸(TNBS)诱导的小鼠T细胞介导的实验性结肠炎[1]。
• 相关类别:
  信号通路 >> 干细胞及 Wnt 通路 >> STAT
  研究领域 >> 癌症
  信号通路 >> 免疫及炎症 >> IFNAR
  信号通路 >> JAK/STAT信号通路 >> STAT
  研究领域 >> 炎症/免疫
• 体外研究: 西林醇(0.1-10μM；96小时)单个混合淋巴细胞反应和cona诱导的T细胞增殖呈剂量依赖性。西林醇(10μM)不影响T淋巴细胞的活力。cirsilineol(10μM)对T细胞增殖的抑制不是由于细胞毒性作用[1]。西林醇(1-10μM；预处理3小时)完全抑制IFN-γ诱导的STAT1和JAK2活化的Tyr701磷酸化[1]。细胞增殖试验[1]细胞系：脾细胞浓度：0.1,1,10μM培养时间：96小时结果：抑制单个混合淋巴细胞反应和刀豆球蛋白A(ConA；5μg/mL；72小时)以剂量依赖性方式诱导T细胞增殖。抑制OVA323-339特异性CD4+T细胞增殖。westernblot分析[1]细胞系：脾CD4+T细胞浓度：1,5,10μM孵育时间：预处理3小时结果：完全抑制IFN-γ诱导(25ng；30分钟)STAT1和JAK2激活的Tyr701磷酸化。抑制IFN-γ诱导(25ng；12小时)Th1特异性转录因子T-bet。
• 体内研究: 西西林醇(3、10和30 mg/kg)通过抑制CD4+T细胞中的IFN-γ/STAT1/T-bet信号,显著改善TNBS诱导的Th1介导的结肠炎。动物模型：8-10周龄雌性C57BL/6、BALB/c和DO11.10转基因小鼠,TNBS(10mg；100μL)[1]剂量：3,10,30mg/kg给药：IP；每日的11天试验结果：对小鼠体重和存活率有显著改善作用。显著减少炎症浸润,恢复破坏性粘膜结构,减轻水肿。
• 参考文献:

  [1]. Yang Sun, et al. Novel immunomodulatory properties of cirsilineol through selective inhibition of IFN-gamma signaling in a murine model of inflammatory bowel disease. Biochem Pharmacol. 2010 Jan 15;79(2):229-38.

MSDS

SECTION 1: Identification of the substance/mixture and of the company/undertaking Product identifiers Product name: Cirsilineol REACH No.: A registration number is not available for this substance as the substance or its uses are exempted from registration, the annual tonnage does not require a registration or the registration is envisaged for a later registration deadline. CAS-No.: 41365-32-6 Relevant identified uses of the substance or mixture and uses advised against Identified uses: Laboratory chemicals, Manufacture of substances SECTION 2: Hazards identification Classification of the substance or mixture Not a hazardous substance or mixture according to Regulation (EC) No. 1272/2008. This substance is not classified as dangerous according to Directive 67/548/EEC. Label elements The product does not need to be labelled in accordance with EC directives or respective national laws. Other hazards - none SECTION 3: Composition/information on ingredients Substances Synonyms: 4',5-Dihydroxy-3',6,7-trimethoxyflavone Anisomelin 6-Methoxyluteolin 3',7-dimethyl ethe Eupatrin Fastigenin Formula: C18H16O7 Molecular Weight: 344,32 g/mol CAS-No.: 41365-32-6 No components need to be disclosed according to the applicable regulations. SECTION 4: First aid measures Description of first aid measures If inhaled If breathed in, move person into fresh air. If not breathing, give artificial respiration. In case of skin contact Wash off with soap and plenty of water. In case of eye contact Flush eyes with water as a precaution. If swallowed Never give anything by mouth to an unconscious person. Rinse mouth with water. Most important symptoms and effects, both acute and delayed The most important known symptoms and effects are described in the labelling (see section 2.2) and/or in section 11 Indication of any immediate medical attention and special treatment needed no data available SECTION 5: Firefighting measures Extinguishing media Suitable extinguishing media Use water spray, alcohol-resistant foam, dry chemical or carbon dioxide. Special hazards arising from the substance or mixture no data available Advice for firefighters Wear self contained breathing apparatus for fire fighting if necessary. Further information no data available SECTION 6: Accidental release measures Personal precautions, protective equipment and emergency procedures Avoid dust formation. Avoid breathing vapours, mist or gas. For personal protection see section 8. Environmental precautions Do not let product enter drains. Methods and materials for containment and cleaning up Sweep up and shovel. Keep in suitable, closed containers for disposal. Reference to other sections For disposal see section 13. SECTION 7: Handling and storage Precautions for safe handling Provide appropriate exhaust ventilation at places where dust is formed. For precautions see section 2.2. Conditions for safe storage, including any incompatibilities Store in cool place. Keep container tightly closed in a dry and well-ventilated place. Recommended storage temperature: -20 °C Specific end use(s) Apart from the uses mentioned in section 1.2 no other specific uses are stipulated SECTION 8: Exposure controls/personal protection Control parameters Components with workplace control parameters Exposure controls Appropriate engineering controls General industrial hygiene practice. Personal protective equipment Eye/face protection Use equipment for eye protection tested and approved under appropriate government standards such as NIOSH (US) or EN 166(EU). Skin protection Handle with gloves. Gloves must be inspected prior to use. Use proper glove removal technique (without touching glove's outer surface) to avoid skin contact with this product. Dispose of contaminated gloves after use in accordance with applicable laws and good laboratory practices. Wash and dry hands. The selected protective gloves have to satisfy the specifications of EU Directive 89/686/EEC and the standard EN 374 derived from it. Full contact Material: Nitrile rubber Minimum layer thickness: 0,11 mm Break through time: 480 min Material tested:Dermatril® (KCL 740 / Z677272, Size M) Splash contact Material: Nitrile rubber Minimum layer thickness: 0,11 mm Break through time: 480 min Material tested:Dermatril® (KCL 740 / Z677272, Size M) data source: KCL GmbH, D-36124 Eichenzell, phone +49 (0)6659 87300, test method: EN374 If used in solution, or mixed with other substances, and under conditions which differ from EN 374, contact the supplier of the CE approved gloves. This recommendation is advisory only and must be evaluated by an industrial hygienist and safety officer familiar with the specific situation of anticipated use by our customers. It should not be construed as offering an approval for any specific use scenario. Body Protection Choose body protection in relation to its type, to the concentration and amount of dangerous substances, and to the specific work-place., The type of protective equipment must be selected according to the concentration and amount of the dangerous substance at the specific workplace. Respiratory protection Respiratory protection is not required. Where protection from nuisance levels of dusts are desired, use type N95 (US) or type P1 (EN 143) dust masks. Use respirators and components tested and approved under appropriate government standards such as NIOSH (US) or CEN (EU). Control of environmental exposure Do not let product enter drains. SECTION 9: Physical and chemical properties Information on basic physical and chemical properties a) AppearanceForm: powder Colour: white, light yellow b) Odourno data available c) Odour Thresholdno data available d) pHno data available e) Melting point/freezing208 - 210 °C point f) Initial boiling point and no data available boiling range g) Flash pointno data available h) Evapouration rateno data available i) Flammability (solid, gas) no data available j) Upper/lowerno data available flammability or explosive limits k) Vapour pressureno data available l) Vapour densityno data available m) Relative densityno data available n) Water solubilityno data available o) Partition coefficient: n- log Pow: 2,689 octanol/water p) Auto-ignitionno data available temperature q) Decompositionno data available temperature r) Viscosityno data available s) Explosive propertiesno data available t) Oxidizing propertiesno data available Other safety information no data available SECTION 10: Stability and reactivity Reactivity no data available Chemical stability Stable under recommended storage conditions. Possibility of hazardous reactions no data available Conditions to avoid no data available Incompatible materials Strong oxidizing agents Hazardous decomposition products Other decomposition products - no data available In the event of fire: see section 5 SECTION 11: Toxicological information Information on toxicological effects Acute toxicity no data available Skin corrosion/irritation no data available Serious eye damage/eye irritation no data available Respiratory or skin sensitisation no data available Germ cell mutagenicity no data available Carcinogenicity IARC:No component of this product present at levels greater than or equal to 0.1% is identified as probable, possible or confirmed human carcinogen by IARC. Reproductive toxicity no data available Specific target organ toxicity - single exposure no data available Specific target organ toxicity - repeated exposure no data available Aspiration hazard no data available Additional Information RTECS: Not available To the best of our knowledge, the chemical, physical, and toxicological properties have not been thoroughly investigated. SECTION 12: Ecological information Toxicity no data available Persistence and degradability no data available Bioaccumulative potential no data available Mobility in soil no data available Results of PBT and vPvB assessment PBT/vPvB assessment not available as chemical safety assessment not required/not conducted Other adverse effects no data available SECTION 13: Disposal considerations Waste treatment methods Product Offer surplus and non-recyclable solutions to a licensed disposal company. Contaminated packaging Dispose of as unused product. SECTION 14: Transport information UN number ADR/RID: -IMDG: -IATA: - UN proper shipping name ADR/RID: Not dangerous goods IMDG: Not dangerous goods IATA:Not dangerous goods Transport hazard class(es) ADR/RID: -IMDG: -IATA: - Packaging group ADR/RID: -IMDG: -IATA: - Environmental hazards ADR/RID: noIMDG Marine pollutant: noIATA: no Special precautions for user no data available SECTION 15 - REGULATORY INFORMATION N/A SECTION 16 - ADDITIONAL INFORMATION N/A

安全

• 危险品运输编码: NONH for all modes of transport
• 海关编码: 2914509090

合成路线

34334-69-5 14031-35-7 ~% 41365-32-6

文献：Berim, Anna; Gang, David R. Phytochemistry, 2013 , vol. 92, p. 33 - 41

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海关

海关编码	2914509090
中文概述	2914509090 含其他含氧基的酮. 增值税率:17.0% 退税率:9.0% 监管条件:无 最惠国关税:5.5% 普通关税:30.0%
申报要素	品名, 成分含量, 用途, 丙酮报明包装
Summary	HS:2914509090 other ketones with other oxygen function VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:5.5% General tariff:30.0%