上海化源世纪贸易有限公司
上海市上海市普陀区
产品名：阿氯米松双丙酸酯
纯度：98.0%
规格：
联系人：徐经理
联系电话：13311869306

上海源溪生物科技有限公司
上海市上海市浦东新区
产品名：Aclovate
纯度：98.9%
规格：1g
联系人：赖经理
联系电话：13564518121

上海脉铂医药科技有限公司
上海市上海市嘉定区
产品名：Alclometasone Dipropionate
纯度：98.0%
规格：25mg/10mg/5mg/1g
联系人：李先生
联系电话：18916172912

上海阿拉丁生化科技股份有限公司
上海市上海市浦东新区
产品名：丙酸氯米松
纯度：98.0%
规格：25mg/1g/1g/1g
联系人：阿拉丁
联系电话：400-620-6333

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66734-13-2生产厂家

66734-13-2价格

66734-13-2

66734-13-2结构式

常用中文名：阿氯米松双丙酸酯
常用英文名：Aclovate
CAS号：66734-13-2
分子式：C₂₈H₃₇ClO₇
分子量：521.04200
相关类别：研究领域炎症/免疫
发布时间：2018-07-13 11:23:15
更新时间：2024-01-04 00:48:50
二丙酸氯米松(Sch 22219)是一种类固醇化合物。二丙酸氯米松可用于皮炎和皮肤瘙痒的研究[1][2]。

化源商城直购

中文名	阿氯米松双丙酸酯
英文名	alclometasone dipropionate
中文别名	7Α-氯-16Α-甲基-11Β,17Α,21-三羟基孕甾-1,4-二烯-3,20-二酮-17,21-二丙酸酯阿克美他松丙酯
英文别名	alclometasone Dipropionate Modrasone alclovate Delonal Almeta Alclometasone-17,21-dipropionate Ddlonal ALCLOMETASONEDIPROPIONATE,USP Aclovate Vitra Aclosone

描述	二丙酸氯米松(Sch 22219)是一种类固醇化合物。二丙酸氯米松可用于皮炎和皮肤瘙痒的研究[1][2]。
相关类别	信号通路 >> 其他 >> 其他研究领域 >> 炎症/免疫
体外研究	丙酸阿氯米松(0.01-100 ng/mL；24 h)抑制人PBMC中CD3/CD2刺激的细胞因子产生,IL-2、IL-3、IL-4、IL-5、IFN-γ和GM-CSF的IC50分别为5.54、1.76、2.09、0.89、3.26和0.76 ng/mL[1]。
体内研究	二丙酸氯米松(0.1%(20μL)；耳朵两侧；一次)显示出对结核菌素和卵清蛋白诱导的过敏反应的影响[2]。动物模型：结核菌素诱导迟发性过敏反应的Lewis大鼠[2]剂量：0.1%(20μL)给药：双侧耳；0.1%(20μ。动物模型：具有卵清蛋白诱导的被动皮肤过敏反应的棕色挪威大鼠[2]剂量：0.1%(20μL)给药：耳朵两侧；0.1%(20μL)卵蛋白激发前6小时结果：显著抑制了这种被动皮肤过敏反应中染料泄漏量的增加。

密度	1.26g/cm3
沸点	636ºC at 760 mmHg
分子式	C₂₈H₃₇ClO₇
分子量	521.04200
闪点	338.4ºC
精确质量	520.22300
PSA	106.97000
LogP	3.94270
折射率	1.562
储存条件	库房通风低温干燥,与食品原料分开存放
分子结构	1、摩尔折射率：133.32 2、摩尔体积（cm³/mol）：411.1 3、等张比容（90.2K）：1099.2 4、表面张力（dyne/cm）：51.1 5、极化率（10-24cm3）：52.85
计算化学	1.疏水参数计算参考值（XlogP）:无 2.氢键供体数量:1 3.氢键受体数量:7 4.可旋转化学键数量:8 5.互变异构体数量:6 6.拓扑分子极性表面积107 7.重原子数量:36 8.表面电荷:0 9.复杂度:1030 10.同位素原子数量:0 11.确定原子立构中心数量:9 12.不确定原子立构中心数量:0 13.确定化学键立构中心数量:0 14.不确定化学键立构中心数量:0 15.共价键单元数量:1
更多	1.性状：从丙酮-甲醇-异丙醚结晶。 2.熔点（℃）：212-216。 3.折射率：+42.6°(C=0.3，二甲基甲酰胺)。

CHEMICAL IDENTIFICATION

RTECS NUMBER :: TU3790000

CHEMICAL NAME :: Pregna-1,4-diene-3,20-dione, 7-chloro-11-hydroxy-16-methyl-17,21-bis(1-oxopropoxy) -, (7-alpha,11-beta,16-alpha)-

CAS REGISTRY NUMBER :: 66734-13-2

LAST UPDATED :: 199612

DATA ITEMS CITED :: 17

MOLECULAR FORMULA :: C28-H37-Cl-O7

MOLECULAR WEIGHT :: 521.10

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 3593 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: -,70,1990

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: >75 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: IYKEDH Iyakuhin Kenkyu. Study of Medical Supplies. (Nippon Koteisho Kyokai, 12-15, 2-chome, Shibuya, Shibuya-ku, Tokyo 150, Japan) V.1- 1970- Volume(issue)/page/year: 19,735,1988

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 3593 mg/kg

TOXIC EFFECTS :: Behavioral - somnolence (general depressed activity) Skin and Appendages - hair

REFERENCE :: KSRNAM Kiso to Rinsho. Clinical Report. (Yubunsha Co., Ltd., 1-5, Kanda Suda-Cho, Chiyoda-ku, KS Bldg., Tokyo 101, Japan) V.1- 1960- Volume(issue)/page/year: 21,1253,1987

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: >5 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: -,70,1990

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 2506 mg/kg

TOXIC EFFECTS :: Behavioral - somnolence (general depressed activity) Skin and Appendages - hair

REFERENCE :: KSRNAM Kiso to Rinsho. Clinical Report. (Yubunsha Co., Ltd., 1-5, Kanda Suda-Cho, Chiyoda-ku, KS Bldg., Tokyo 101, Japan) V.1- 1960- Volume(issue)/page/year: 21,1253,1987

TYPE OF TEST :: LD - Lethal dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Mammal - dog

DOSE/DURATION :: >15 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: -,70,1990

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Mammal - dog

DOSE/DURATION :: >15 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: IYKEDH Iyakuhin Kenkyu. Study of Medical Supplies. (Nippon Koteisho Kyokai, 12-15, 2-chome, Shibuya, Shibuya-ku, Tokyo 150, Japan) V.1- 1970- Volume(issue)/page/year: 19,735,1988 ** OTHER MULTIPLE DOSE TOXICITY DATA **

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 9 mg/kg/90D-I

TOXIC EFFECTS :: Blood - changes in leukocyte (WBC) count Blood - changes in platelet count Nutritional and Gross Metabolic - weight loss or decreased weight gain

REFERENCE :: KSRNAM Kiso to Rinsho. Clinical Report. (Yubunsha Co., Ltd., 1-5, Kanda Suda-Cho, Chiyoda-ku, KS Bldg., Tokyo 101, Japan) V.1- 1960- Volume(issue)/page/year: 21,1351,1987

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 18250 ug/kg/1Y-I

TOXIC EFFECTS :: Blood - pigmented or nucleated red blood cells Blood - other changes Nutritional and Gross Metabolic - weight loss or decreased weight gain

REFERENCE :: KSRNAM Kiso to Rinsho. Clinical Report. (Yubunsha Co., Ltd., 1-5, Kanda Suda-Cho, Chiyoda-ku, KS Bldg., Tokyo 101, Japan) V.1- 1960- Volume(issue)/page/year: 21,1437,1987

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 9 mg/kg/90D-I

TOXIC EFFECTS :: Endocrine - changes in spleen weight Blood - changes in serum composition (e.g. TP, bilirubin, cholesterol) Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - transaminases

REFERENCE :: KSRNAM Kiso to Rinsho. Clinical Report. (Yubunsha Co., Ltd., 1-5, Kanda Suda-Cho, Chiyoda-ku, KS Bldg., Tokyo 101, Japan) V.1- 1960- Volume(issue)/page/year: 21,1309,1987

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Mammal - dog

DOSE/DURATION :: 18 mg/kg/90D-C

TOXIC EFFECTS :: Liver - other changes Endocrine - adrenal cortex hypoplasia Blood - other changes

REFERENCE :: KSRNAM Kiso to Rinsho. Clinical Report. (Yubunsha Co., Ltd., 1-5, Kanda Suda-Cho, Chiyoda-ku, KS Bldg., Tokyo 101, Japan) V.1- 1960- Volume(issue)/page/year: 21,1389,1987

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Mammal - dog

DOSE/DURATION :: 36500 ug/kg/1Y-I

TOXIC EFFECTS :: Endocrine - changes in adrenal weight Blood - changes in serum composition (e.g. TP, bilirubin, cholesterol) Nutritional and Gross Metabolic - weight loss or decreased weight gain

REFERENCE :: KSRNAM Kiso to Rinsho. Clinical Report. (Yubunsha Co., Ltd., 1-5, Kanda Suda-Cho, Chiyoda-ku, KS Bldg., Tokyo 101, Japan) V.1- 1960- Volume(issue)/page/year: 21,1483,1987 ** REPRODUCTIVE DATA **

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Subcutaneous

DOSE :: 11 mg/kg

SEX/DURATION :: female 7-17 day(s) after conception

TOXIC EFFECTS :: Reproductive - Specific Developmental Abnormalities - musculoskeletal system Reproductive - Effects on Newborn - growth statistics (e.g.%, reduced weight gain)

REFERENCE :: OYYAA2 Oyo Yakuri. Pharmacometrics. (Oyo Yakuri Kenkyukai, CPO Box 180, Sendai 980-91, Japan) V.1- 1967- Volume(issue)/page/year: 33,301,1987

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Subcutaneous

DOSE :: 1100 ug/kg

SEX/DURATION :: female 7-17 day(s) after conception

TOXIC EFFECTS :: Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death, e.g., stunted fetus)

REFERENCE :: OYYAA2 Oyo Yakuri. Pharmacometrics. (Oyo Yakuri Kenkyukai, CPO Box 180, Sendai 980-91, Japan) V.1- 1967- Volume(issue)/page/year: 33,301,1987

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Administration onto the skin

DOSE :: 18 mg/kg

SEX/DURATION :: male 90 day(s) pre-mating

TOXIC EFFECTS :: Reproductive - Paternal Effects - prostate, seminal vesicle, Cowper's gland, accessory glands

REFERENCE :: KSRNAM Kiso to Rinsho. Clinical Report. (Yubunsha Co., Ltd., 1-5, Kanda Suda-Cho, Chiyoda-ku, KS Bldg., Tokyo 101, Japan) V.1- 1960- Volume(issue)/page/year: 21,1389,1987

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Administration onto the skin

DOSE :: 18 mg/kg

SEX/DURATION :: female 90 day(s) pre-mating

TOXIC EFFECTS :: Reproductive - Maternal Effects - ovaries, fallopian tubes Reproductive - Maternal Effects - uterus, cervix, vagina

REFERENCE :: KSRNAM Kiso to Rinsho. Clinical Report. (Yubunsha Co., Ltd., 1-5, Kanda Suda-Cho, Chiyoda-ku, KS Bldg., Tokyo 101, Japan) V.1- 1960- Volume(issue)/page/year: 21,1389,1987

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Administration onto the skin

DOSE :: 1300 ug/kg

SEX/DURATION :: female 6-18 day(s) after conception

TOXIC EFFECTS :: Reproductive - Fertility - pre-implantation mortality (e.g. reduction in number of implants per female; total number of implants per corpora lutea) Reproductive - Fertility - litter size (e.g. # fetuses per litter; measured before birth)

REFERENCE :: OYYAA2 Oyo Yakuri. Pharmacometrics. (Oyo Yakuri Kenkyukai, CPO Box 180, Sendai 980-91, Japan) V.1- 1967- Volume(issue)/page/year: 33,343,1987

符号	GHS08
信号词	Warning
危害声明	H361d
警示性声明	P280
危险品运输编码	NONH for all modes of transport

67212-74-2

~15%

66734-13-2

文献：Shue; Green; Berkenkoph; Monahan; Fernandez; Lutsky Journal of Medicinal Chemistry, 1980 , vol. 23, # 4 p. 430 - 437

13209-52-4

66734-13-2

文献：Journal of Medicinal Chemistry, , vol. 23, # 4 p. 430 - 437

13954-10-4

66734-13-2

文献：Journal of Medicinal Chemistry, , vol. 23, # 4 p. 430 - 437

13796-64-0

66734-13-2

文献：Journal of Medicinal Chemistry, , vol. 23, # 4 p. 430 - 437

67212-72-0

66734-13-2

文献：Journal of Medicinal Chemistry, , vol. 23, # 4 p. 430 - 437

上游产品 4
67212-74-2 13209-52-4 13954-10-4 67212-72-0
下游产品 1
67452-97-5

化合物(Ⅰ)在2，3-二氯-5，6-二氰基苯醌(DDQ)作用下，脱去一分子氢，在6、7位形成双键，而得化合物(Ⅱ)。碳酸氢钠水解21位的酯后，和原丙酸三乙酯反应，使17位和21位的羟基形成环状原甲酸酯(Ⅳ)。在醋酸中重排成17位丙酸酯(V)。然后和丙酸酐反应，使21位羟基成丙酸酯，而得到双丙酸酯(Ⅵ)。最后和氯化氢加成，得到双丙酸阿氯米松。总收率2.678%。

66734-13-2	887130-69-0
1204582-47-7	5534-09-8
67452-97-5	52619-18-8
3793-10-0	15423-89-9
1186048-33-8	75883-07-7
1251148-56-7	1184950-33-1
1158522-08-7	940364-43-2
134104-43-1	131615-57-1
6906-52-1	1179030-28-4
930439-75-1	1018584-77-4