84-12-8

• 常用中文名：泛喹酮
• 常用英文名：Phanquinone
• CAS号：84-12-8
• 分子式：C₁₂H₆N₂O₂
• 分子量：210.19
• 相关类别： 原料药 抗寄生虫病药 抗阿米巴病及抗滴虫病药
• 发布时间：2018-09-18 12:32:50
• 更新时间：2024-01-09 12:16:50
• Phanquone (11925 C, Entronon) 是由4,7-菲罗啉的氢化物衍生而来。Phanquone被用作氨基酸的原始柱前衍生试剂。

名称

• 中文名: 泛喹酮
• 英文名: phanquone
• 中文别名: 安妥夫百舒
• 英文别名: Fanquinona; 5,6-Dioxo-5,6-dihydro-4,7-phenanthroline; [4,7]Phenanthroline-5,6-dione; phanquinonum [INN_en]; [4,7]Phenanthrolin-5,6-dion; 4,7-Phenanthroline-5,6-dione; Phanquinone; Entobex; Phanchinone; Entronon; 4,7-Phenanthrolene-5,6-quinone; Phanquinonum; Phanchinonum; phanquone; Enthohex

物化性质

• 密度: 1.4±0.1 g/cm3
• 沸点: 456.1±20.0 °C at 760 mmHg
• 熔点: 295° (dec)
• 分子式: C₁₂H₆N₂O₂
• 分子量: 210.19
• 闪点: 229.1±28.2 °C
• 精确质量: 210.042923
• PSA: 59.92000
• LogP: 0.15
• 蒸汽压: 0.0±1.1 mmHg at 25°C
• 折射率: 1.678
• 储存条件: 室温， 密封， 干燥

生物活性

• 描述: Phanquone (11925 C, Entronon) 是由4,7-菲罗啉的氢化物衍生而来。Phanquone被用作氨基酸的原始柱前衍生试剂。
• 相关类别:
  研究领域 >> 其他
  信号通路 >> 其他 >> 其他
• 参考文献:

  [1]. Gotti R, et al. Phanquinone as a suitable derivatization reagent in micellar electrokinetic chromatography and HPLC analysis of amino acids. J Sep Sci. 2006;29(9):1259-1267.

毒性和生态

CHEMICAL IDENTIFICATION RTECS NUMBER : SF8423000 CHEMICAL NAME : 4,7-Phenanthroline-5,6-dione CAS REGISTRY NUMBER : 84-12-8 BEILSTEIN REFERENCE NO. : 0160657 LAST UPDATED : 199709 DATA ITEMS CITED : 4 MOLECULAR FORMULA : C12-H6-N2-O2 MOLECULAR WEIGHT : 210.20 WISWESSER LINE NOTATION : T B666 FN HVV KNJ HEALTH HAZARD DATA ACUTE TOXICITY DATA TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 5 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 4 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Unreported SPECIES OBSERVED : Mammal - species unspecified DOSE/DURATION : 6300 mg/kg/21D-I TOXIC EFFECTS : Kidney, Ureter, Bladder - changes in tubules (including acute renal failure, acute tubular necrosis) MUTATION DATA TYPE OF TEST : Sex chromosome loss and nondisjunction TEST SYSTEM : Mold - Aspergillus nidulans DOSE/DURATION : 1 gm/L REFERENCE : MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 26,159,1974

安全

• 海关编码: 2933990090

合成路线

951-06-4 ~84% 84-12-8

文献：Bonhote, Pierre; Wrighton, Mark S. Synlett, 1997 , vol. 1997, # 8 p. 897 - 898

66671-82-7 ~% 84-12-8

文献：Dalton Transactions, , # 8 p. 1060 - 1072

5307-02-8 ~% 84-12-8

文献：Synlett, , vol. 1997, # 8 p. 897 - 898

51837-64-0 ~% 84-12-8

文献：Synlett, , vol. 1997, # 8 p. 897 - 898

951-06-4 7664-93-9 7697-37-2 ~% 84-12-8

文献：Chemische Berichte, , vol. 95, p. 2395 - 2402 Helvetica Chimica Acta, , vol. 33, p. 1080,1085

上下游产品

上游产品  6
951-06-4 66671-82-7 5307-02-8 51837-64-0
7664-93-9 7697-37-2
下游产品  6
54078-29-4 91330-41-5 613-45-6 104-87-0
3723-32-8 99971-15-0

海关

海关编码	2933990090
中文概述	2933990090. 其他仅含氮杂原子的杂环化合物. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:20.0%
申报要素	品名, 成分含量, 用途, 乌洛托品请注明外观, 6－己内酰胺请注明外观, 签约日期
Summary	2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%