1197-60-0

• 常用中文名：5-甲基青光胺
• 常用英文名：2-Furanmethanaminium,N,N,N,5-tetramethyl-, iodide (1:1)
• CAS号：1197-60-0
• 分子式：C₉H₁₆INO
• 分子量：281.13
• 相关类别： 研究领域 神经疾病
• 发布时间：2018-07-01 17:51:11
• 更新时间：2024-01-10 17:29:35
• Methylfurmethide 是一种乙酰胆碱受体。Methylfurmethide 可以阻断阿托品的摄取。Methylfurmethide 可用于肠平滑肌中乙酰胆碱受体特性的研究。

名称

• 中文名: 5-甲基青光胺
• 英文名: trimethyl-[(5-methylfuran-2-yl)methyl]azanium,iodide
• 中文别名: 5-甲呋硫碘
• 英文别名: methylfurmethide; 5-Methylfurfuryltrimethylammonium iodide; Methylfurmetide; 5 MFT; 5-Methylfurtrethonium iodide; Preparation 7070; 5-Methylfurmithide; Methylfurmethide iodide

物化性质

• 分子式: C₉H₁₆INO
• 分子量: 281.13
• 精确质量: 281.02800
• PSA: 13.14000
• 外观性状: 白色固体
• 储存条件:

  密封储存，储存于阴凉、干燥的库房。

• 稳定性:

  常温常压下稳定，避免与强氧化剂接触。

• 计算化学:

  1.疏水参数计算参考值（XlogP）:无

  2.氢键供体数量:0

  3.氢键受体数量:2

  4.可旋转化学键数量:2

  5.互变异构体数量:无

  6.拓扑分子极性表面积13.1

  7.重原子数量:12

  8.表面电荷:0

  9.复杂度:128

  10.同位素原子数量:0

  11.确定原子立构中心数量:0

  12.不确定原子立构中心数量:0

  13.确定化学键立构中心数量:0

  14.不确定化学键立构中心数量:0

  15.共价键单元数量:2

• 更多:

  1. 性状：固体

  2. 密度（g/mL,25℃）：未确定

  3. 相对蒸汽密度（g/mL,空气=1）：未确定

  4. 熔点（ºC）：未确定

  5. 沸点（ºC,常压）：未确定

  6. 沸点（ºC，2mmHg）：未确定

  7. 折射率(n20/D)：未确定

  8. 闪点（ºC）：未确定

  9. 比旋光度（º）：未确定

  10. 自燃点或引燃温度（ºC）：未确定

  11. 蒸气压（mmHg,20ºC）：未确定

  12. 饱和蒸气压（kPa,25ºC）：未确定

  13. 燃烧热（KJ/mol）：未确定

  14. 临界温度（ºC）：未确定

  15. 临界压力（KPa）：未确定

  16. 油水（辛醇/水）分配系数的对数值：未确定

  17. 爆炸上限（%,V/V）：未确定

  18. 爆炸下限（%,V/V）：未确定

  19. 溶解性：未确定

生物活性

• 描述: Methylfurmethide 是一种乙酰胆碱受体。Methylfurmethide 可以阻断阿托品的摄取。Methylfurmethide 可用于肠平滑肌中乙酰胆碱受体特性的研究。
• 相关类别:
  信号通路 >> 其他 >> 其他
  研究领域 >> 神经疾病
• 参考文献:

  [1]. PATON WD, et al. THE UPTAKE OF ATROPINE AND RELATED DRUGS BY INTESTINAL SMOOTH MUSCLE OF THE GUINEA-PIG IN RELATION TO ACETYLCHOLINE RECEPTORS. Proc R Soc Lond B Biol Sci. 1965 Aug 24;163:1-44.

MSDS

Section1. IDENTIFICATION OF THE SUBSTANCE/MIXTURE Product identifiers Product name: 5-Methylfurmethide CAS-No.: 1197-60-0 Relevant identified uses of the substance or mixture and uses advised against Identified uses: Laboratory chemicals, Manufacture of substances Section2. HAZARDS IDENTIFICATION Classification of the substance or mixture Classification according to Regulation (EC) No 1272/2008 [EU-GHS/CLP] Skin sensitization (Category 1) Reproductive toxicity (Category 1B) Classification according to EU Directives 67/548/EEC or 1999/45/EC May cause sensitization by inhalation and skin contact. May cause harm to the unborn child. Label elements Labelling according Regulation (EC) No 1272/2008 [CLP] Pictogram Signal wordDanger Hazard statement(s) H317May cause an allergic skin reaction. H360May damage fertility or the unborn child. Precautionary statement(s) P201Obtain special instructions before use. P280Wear protective gloves. P308 + P313IF exposed or concerned: Get medical advice/ attention. Supplemental Hazardnone Statements Restricted to professional users. According to European Directive 67/548/EEC as amended. Hazard symbol(s) R-phrase(s) R42/43May cause sensitization by inhalation and skin contact. R61May cause harm to the unborn child. S-phrase(s) S36/37Wear suitable protective clothing and gloves. S22Do not breathe dust. S53Avoid exposure - obtain special instructions before use. S45In case of accident or if you feel unwell, seek medical advice immediately (show the label where possible). Restricted to professional users. Other hazards - none Section3. COMPOSITION/INFORMATION ON INGREDIENTS Substances Formula: C9H16INO Molecular Weight: 281,14 g/mol ComponentConcentration 5-Methylfurmethide CAS-No.1197-60-0- Section4. FIRST AID MEASURES Description of first aid measures General advice Consult a physician. Show this safety data sheet to the doctor in attendance. If inhaled If breathed in, move person into fresh air. If not breathing, give artificial respiration. Consult a physician. In case of skin contact Wash off with soap and plenty of water. Consult a physician. In case of eye contact Flush eyes with water as a precaution. If swallowed Never give anything by mouth to an unconscious person. Rinse mouth with water. Consult a physician. Most important symptoms and effects, both acute and delayed To the best of our knowledge, the chemical, physical, and toxicological properties have not been thoroughly investigated., Prolonged exposure to iodides may produce iodism in sensitive individuals. Symptoms of exposure include: skin rash, running nose, headache and irritation of the mucous membrane. For severe cases the skin may show pimples, boils, hives, blisters and black and blue spots. Iodides are readily diffused across the placenta. Neonatal deaths from respiratory distress secondary to goiter have been reported. Iodides have been known to cause drug-induced fevers, which are usually of short duration. Indication of any immediate medical attention and special treatment needed no data available Section5. FIREFIGHTING MEASURES Extinguishing media Suitable extinguishing media Use water spray, alcohol-resistant foam, dry chemical or carbon dioxide. Special hazards arising from the substance or mixture Carbon oxides, nitrogen oxides (NOx), Hydrogen iodide Advice for firefighters Wear self contained breathing apparatus for fire fighting if necessary. Further information no data available Section6. ACCIDENTAL RELEASE MEASURES Personal precautions, protective equipment and emergency procedures Use personal protective equipment. Avoid dust formation. Avoid breathing vapors, mist or gas. Ensure adequate ventilation. Evacuate personnel to safe areas. Avoid breathing dust. Environmental precautions Prevent further leakage or spillage if safe to do so. Do not let product enter drains. Methods and materials for containment and cleaning up Pick up and arrange disposal without creating dust. Sweep up and shovel. Keep in suitable, closed containers for disposal. Reference to other sections For disposal see section 13. Section7. HANDLING AND STORAGE Precautions for safe handling Avoid exposure - obtain special instructions before use.Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Provide appropriate exhaust ventilation at places where dust is formed.Normal measures for preventive fire protection. Conditions for safe storage, including any incompatibilities Store in cool place. Keep container tightly closed in a dry and well-ventilated place. Specific end uses no data available Section8. EXPOSURE CONTROLS/PERSONAL PROTECTION Control parameters Components with workplace control parameters Exposure controls Appropriate engineering controls Handle in accordance with good industrial hygiene and safety practice. Wash hands before breaks and at the end of workday. Personal protective equipment Eye/face protection Face shield and safety glasses Use equipment for eye protection tested and approved under appropriate government standards such as NIOSH (US) or EN 166(EU). Skin protection Handle with gloves. Gloves must be inspected prior to use. Use proper glove removal technique (without touching glove's outer surface) to avoid skin contact with this product. Dispose of contaminated gloves after use in accordance with applicable laws and good laboratory practices. Wash and dry hands. The selected protective gloves have to satisfy the specifications of EU Directive 89/686/EEC and the standard EN 374 derived from it. Body Protection Complete suit protecting against chemicals, The type of protective equipment must be selected according to the concentration and amount of the dangerous substance at the specific workplace. Respiratory protection Where risk assessment shows air-purifying respirators are appropriate use a full-face particle respirator type N100 (US) or type P3 (EN 143) respirator cartridges as a backup to engineering controls. If the respirator is the sole means of protection, use a full-face supplied air respirator. Use respirators and components tested and approved under appropriate government standards such as NIOSH (US) or CEN (EU). Section9. PHYSICAL AND CHEMICAL PROPERTIES Information on basic physical and chemical properties a) AppearanceForm: solid b) Odourno data available c) Odour Thresholdno data available d) pHno data available e) Melting point/freezingno data available point f) Initial boiling point and no data available boiling range g) Flash pointno data available h) Evaporation rateno data available i) Flammability (solid, gas) no data available j) Upper/lowerno data available flammability or explosive limits k) Vapour pressureno data available l) Vapour densityno data available m) Relative densityno data available n) Water solubilityno data available o) Partition coefficient: n- no data available octanol/water p) Autoignitionno data available temperature q) Decompositionno data available temperature r) Viscosityno data available s) Explosive propertiesno data available t) Oxidizing propertiesno data available Other safety information no data available Section10. STABILITY AND REACTIVITY Reactivity no data available Chemical stability no data available Possibility of hazardous reactions no data available Conditions to avoid no data available Incompatible materials Oxidizing agents Hazardous decomposition products Other decomposition products - no data available Section11. TOXICOLOGICAL INFORMATION Information on toxicological effects Acute toxicity LD50 Subcutaneous - mouse - 33 mg/kg LD50 Intravenous - mouse - 3,795 mg/kg Remarks: Sense Organs and Special Senses (Nose, Eye, Ear, and Taste):Eye:Lacrimation. Gastrointestinal:Changes in structure or function of salivary glands. Kidney, Ureter, Bladder:Incontinence. Skin corrosion/irritation no data available Serious eye damage/eye irritation no data available Respiratory or skin sensitization May cause allergic skin reaction. Germ cell mutagenicity no data available Carcinogenicity IARC:No component of this product present at levels greater than or equal to 0.1% is identified as probable, possible or confirmed human carcinogen by IARC. Reproductive toxicity May cause congenital malformation in the fetus. Presumed human reproductive toxicant Specific target organ toxicity - single exposure no data available Specific target organ toxicity - repeated exposure no data available Aspiration hazard no data available Potential health effects InhalationMay be harmful if inhaled. May cause respiratory tract irritation. IngestionMay be harmful if swallowed. SkinMay be harmful if absorbed through skin. May cause skin irritation. EyesMay cause eye irritation. Signs and Symptoms of Exposure To the best of our knowledge, the chemical, physical, and toxicological properties have not been thoroughly investigated., Prolonged exposure to iodides may produce iodism in sensitive individuals. Symptoms of exposure include: skin rash, running nose, headache and irritation of the mucous membrane. For severe cases the skin may show pimples, boils, hives, blisters and black and blue spots. Iodides are readily diffused across the placenta. Neonatal deaths from respiratory distress secondary to goiter have been reported. Iodides have been known to cause drug-induced fevers, which are usually of short duration. Additional Information RTECS: BR7980000 Section12. ECOLOGICAL INFORMATION Toxicity no data available Persistence and degradability no data available Bioaccumulative potential no data available Mobility in soil no data available Results of PBT and vPvB assessment no data available Other adverse effects no data available Section13. DISPOSAL CONSIDERATIONS Waste treatment methods Product Offer surplus and non-recyclable solutions to a licensed disposal company. Contact a licensed professional waste disposal service to dispose of this material. Dissolve or mix the material with a combustible solvent and burn in a chemical incinerator equipped with an afterburner and scrubber. Contaminated packaging Dispose of as unused product. Section14. TRANSPORT INFORMATION UN number ADR/RID: -IMDG: -IATA: - UN proper shipping name ADR/RID: Not dangerous goods IMDG: Not dangerous goods IATA:Not dangerous goods Transport hazard class(es) ADR/RID: -IMDG: -IATA: - Packaging group ADR/RID: -IMDG: -IATA: - Environmental hazards ADR/RID: noIMDG Marine pollutant: noIATA: no Special precautions for user no data available SECTION 15 - REGULATORY INFORMATION N/A SECTION 16 - ADDITIONAL INFORMATION N/A

毒性和生态

毒理学数据: 1、急性毒性：小鼠经皮下LD50：33mg/kg；小鼠经静脉LD50：3795μg/kg； CHEMICAL IDENTIFICATION RTECS NUMBER : BR7980000 CHEMICAL NAME : Ammonium, (5-methylfurfuryl)trimethyl-, iodide CAS REGISTRY NUMBER : 1197-60-0 LAST UPDATED : 199206 DATA ITEMS CITED : 2 MOLECULAR FORMULA : C9-H16-N-O.I MOLECULAR WEIGHT : 281.16 WISWESSER LINE NOTATION : T5OJ B1K1&1&1 E1 &I HEALTH HAZARD DATA ACUTE TOXICITY DATA TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Subcutaneous SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 33 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : BJPCAL British Journal of Pharmacology and Chemotherapy. (London, UK) V.1-33, 1946-68. For publisher information, see BJPCBM. Volume(issue)/page/year: 7,130,1952 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 3795 ug/kg TOXIC EFFECTS : Sense Organs and Special Senses (Eye) - lacrimation Gastrointestinal - changes in structure or function of salivary glands Kidney, Ureter, Bladder - incontinence REFERENCE : TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year: 37,184,1976

安全

• 海关编码: 2932190090

合成路线

14496-35-6 ~% 1197-60-0

文献：Ing et al. British Journal of Pharmacology and Chemotherapy, 1952 , vol. 7, p. 103,114 Full Text Show Details Eliel; Peckham Journal of the American Chemical Society, 1950 , vol. 72, p. 1209,1210

14496-35-6 74-88-4 ~% 1197-60-0

文献：Gready, Jill E.; Hambley, Trevor W.; Kakiuchi, Kiyomi; Kobiro, Kazuya; Sternhell, Sever; Tansey, Charles W.; Tobe, Yoshito Journal of the American Chemical Society, 1990 , vol. 112, # 21 p. 7537 - 7540

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海关

海关编码	2932190090
中文概述	2932190090 其他结构上有非稠合呋喃环化合物. 增值税率:17.0% 退税率:9.0% 监管条件:无 最惠国关税:6.5% 普通关税:20.0%
申报要素	品名, 成分含量, 用途
Summary	2932190090 other compounds containing an unfused furan ring (whether or not hydrogenated) in the structure VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:20.0%