549-84-8

• 常用中文名：Beta-育亨宾
• 常用英文名：b-Yohimbine
• CAS号：549-84-8
• 分子式：C₂₁H₂₆N₂O₃
• 分子量：354.443
• 相关类别： 天然产物 生物碱
• 发布时间：2018-08-21 14:18:34
• 更新时间：2024-01-06 20:13:24
• β-Yohimbine (Amsonin) 是一种吲哚生物碱,可以从 Aspidosperma ulei Markgr 中分离出来。β-Yohimbine 对氯喹 (Chloroquine (HY-17589A)) 耐药 Fc M29-Cameroon 菌株表现出抗疟原虫活性 (IC50: > 1 μg/mL)。

名称

• 中文名: BETA-育亨宾
• 英文名: .β.-Yohimbine
• 英文别名: Methyl (16α,17β)-17-hydroxyyohimban-16-carboxylate; Yohimban-16α-carboxylic acid, 17β-hydroxy-, methyl ester; Yohimban-16-α-carboxylic acid, 17-β-hydroxy-, methyl ester; .beta.-Yohimbine; Amsonin; Yohimban-16α-carboxylic acid, 17β-hydroxy-, methyl ester (8CI); Yohimban-16-carboxylic acid, 17-hydroxy-, methyl ester, (16α,17β)-; Amsonine; b-Yohimbine; β-Yohimbine

物化性质

• 密度: 1.3±0.1 g/cm3
• 沸点: 543.0±50.0 °C at 760 mmHg
• 分子式: C₂₁H₂₆N₂O₃
• 分子量: 354.443
• 闪点: 282.2±30.1 °C
• 精确质量: 354.194336
• PSA: 65.56000
• LogP: 2.20
• 外观性状: 粉末
• 蒸汽压: 0.0±1.5 mmHg at 25°C
• 折射率: 1.661
• 储存条件: 2-8℃，干燥，密闭

生物活性

• 描述: β-Yohimbine (Amsonin) 是一种吲哚生物碱,可以从 Aspidosperma ulei Markgr 中分离出来。β-Yohimbine 对氯喹 (Chloroquine (HY-17589A)) 耐药 Fc M29-Cameroon 菌株表现出抗疟原虫活性 (IC50: > 1 μg/mL)。
• 相关类别:
  研究领域 >> 感染
• 参考文献:

  [1]. dos Santos Torres ZE, et al. Chemical composition of Aspidosperma ulei Markgr. and antiplasmodial activity of selected indole alkaloids. Molecules. 2013 May 29;18(6):6281-97.

毒性和生态

CHEMICAL IDENTIFICATION RTECS NUMBER : ZG1000030 CHEMICAL NAME : Yohimban-16-alpha-carboxylic acid, 17-beta-hydroxy-, methyl ester CAS REGISTRY NUMBER : 549-84-8 LAST UPDATED : 199007 DATA ITEMS CITED : 3 MOLECULAR FORMULA : C21-H26-N2-O3 MOLECULAR WEIGHT : 354.49 HEALTH HAZARD DATA ACUTE TOXICITY DATA TYPE OF TEST : LDLo - Lowest published lethal dose ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 1 gm/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : 85IXA4 "Structure et Activite Pharmacodyanmique des Medicaments du Systeme Nerveux Vegetatif," Bovet, D., and F. Bovet-Nitti, New York, S. Karger, 1948 Volume(issue)/page/year: -,317,1948 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 68 mg/kg TOXIC EFFECTS : Behavioral - somnolence (general depressed activity) Behavioral - convulsions or effect on seizure threshold Lungs, Thorax, or Respiration - other changes REFERENCE : NYKZAU Nippon Yakurigaku Zasshi. Japanese Journal of Pharmacology. (Nippon Yakuri Gakkai, c/o Kyoto Daigaku Igakubu Yakurigaku Kyoshitsu, Konoe-cho, Yoshida, Sakyo-ku, Kyoto 606, Japan) V.40- 1944- Volume(issue)/page/year: 94,17,1989 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 5400 ug/kg TOXIC EFFECTS : Behavioral - somnolence (general depressed activity) Behavioral - convulsions or effect on seizure threshold Lungs, Thorax, or Respiration - other changes REFERENCE : NYKZAU Nippon Yakurigaku Zasshi. Japanese Journal of Pharmacology. (Nippon Yakuri Gakkai, c/o Kyoto Daigaku Igakubu Yakurigaku Kyoshitsu, Konoe-cho, Yoshida, Sakyo-ku, Kyoto 606, Japan) V.40- 1944- Volume(issue)/page/year: 94,17,1989

安全

• 危害码 (欧洲): Xi

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