83463-62-1

• 常用中文名：溴代氯乙腈
• 常用英文名：UNII:SHY3J1BBQ6
• CAS号：83463-62-1
• 分子式：C₂HBrClN
• 分子量：154.393
• 相关类别： 信号通路 细胞周期/DNA损伤 DNA/RNA合成
• 发布时间：2018-02-09 08:00:00
• 更新时间：2024-01-08 17:13:16
• Bromochloroacetonitrile 是含天然有机物水的氯消毒副产物。Bromochloroacetonitrile 具有直接致突变活性,能诱导 DNA 链断裂。

名称

• 中文名: 溴代氯乙腈
• 英文名: Bromochloroacetonitrile
• 中文别名: 溴氯乙腈
• 英文别名: Acetonitrile, 2-bromo-2-chloro-; BROMOCHLOROACETONITRILE; Bromo(chloro)acetonitrile; UNII:SHY3J1BBQ6; 2-bromo-2-chloroacetonitrile

物化性质

• 密度: 1.9±0.1 g/cm3
• 沸点: 121.1±20.0 °C at 760 mmHg
• 分子式: C₂HBrClN
• 分子量: 154.393
• 闪点: 27.1±21.8 °C
• 精确质量: 152.898087
• PSA: 23.79000
• LogP: 1.23
• 蒸汽压: 14.8±0.2 mmHg at 25°C
• 折射率: 1.507
• 储存条件: 库房通风干燥低温

生物活性

• 描述: Bromochloroacetonitrile 是含天然有机物水的氯消毒副产物。Bromochloroacetonitrile 具有直接致突变活性,能诱导 DNA 链断裂。
• 相关类别:
  信号通路 >> 细胞周期/DNA损伤 >> DNA/RNA合成
  研究领域 >> 其他
• 体外研究: 溴氯乙腈(BCAN)诱导中国仓鼠卵巢细胞姐妹染色单体互换[1]。
• 参考文献:

  [1]. Suzanne A. et al.The developmental toxicity of bromochloroacetonitrile in pregnant long‐evans rats, International Journal of Environmental Health Research, 5:2, 175-188.

毒性和生态

CHEMICAL IDENTIFICATION RTECS NUMBER : AL8010000 CHEMICAL NAME : Acetonitrile, bromochloro- CAS REGISTRY NUMBER : 83463-62-1 LAST UPDATED : 199607 DATA ITEMS CITED : 14 MOLECULAR FORMULA : C2-H-Br-Cl-N MOLECULAR WEIGHT : 154.40 WISWESSER LINE NOTATION : NCYGE HEALTH HAZARD DATA ACUTE TOXICITY DATA TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Administration onto the skin SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 2400 mg/kg/2W-I TOXIC EFFECTS : Tumorigenic - Carcinogenic by RTECS criteria Skin and Appendages - tumors TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Oral DOSE : 825 mg/kg SEX/DURATION : female 7-21 day(s) after conception TOXIC EFFECTS : Reproductive - Effects on Newborn - growth statistics (e.g.%, reduced weight gain) TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Oral DOSE : 845 mg/kg SEX/DURATION : female 6-18 day(s) after conception TOXIC EFFECTS : Reproductive - Maternal Effects - other effects TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Oral DOSE : 585 mg/kg SEX/DURATION : female 6-18 day(s) after conception TOXIC EFFECTS : Reproductive - Fertility - litter size (e.g. # fetuses per litter; measured before birth) Reproductive - Specific Developmental Abnormalities - musculoskeletal system TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Oral DOSE : 65 mg/kg SEX/DURATION : female 6-18 day(s) after conception TOXIC EFFECTS : Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death, e.g., stunted fetus) Reproductive - Specific Developmental Abnormalities - cardiovascular (circulatory) system TYPE OF TEST : Micronucleus test MUTATION DATA TYPE OF TEST : Sister chromatid exchange TEST SYSTEM : Rodent - hamster Ovary DOSE/DURATION : 4200 nmol/L REFERENCE : FAATDF Fundamental and Applied Toxicology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1981- Volume(issue)/page/year: 5,1065,1985 *** REVIEWS *** IARC Cancer Review:Animal Inadequate Evidence IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- Volume(issue)/page/year: 52,269,1991 IARC Cancer Review:Human No Available Data IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- Volume(issue)/page/year: 52,269,1991 IARC Cancer Review:Group 3 IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- Volume(issue)/page/year: 52,269,1991

安全

• 危害码 (欧洲): Xn
• 风险声明 (欧洲): R23/24/25;R34
• 安全声明 (欧洲): S26-S36/37/39-S45
• 危险品运输编码: UN 1760
• RTECS号: AL8010000
• 包装等级: III
• 危险类别: 8
• 海关编码: 2926909090

合成路线

107-14-2 ~% 75519-19-6 83463-62-1 144772-39-4

文献：Water Research, , vol. 33, # 8 p. 1938 - 1948

海关

海关编码	2926909090
中文概述	2926909090 其他腈基化合物. 增值税率:17.0% 退税率:9.0% 监管条件:无 最惠国关税:6.5% 普通关税:30.0%
申报要素	品名, 成分含量, 用途
Summary	HS:2926909090 other nitrile-function compounds VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:30.0%