73231-34-2

• 常用中文名：氟苯尼考
• 常用英文名：Florfenicol
• CAS号：73231-34-2
• 分子式：C₁₂H₁₄Cl₂FNO₄S
• 分子量：358.213
• 相关类别： 原料药 解热镇痛药 非甾抗炎药
• 发布时间：2018-02-04 08:00:00
• 更新时间：2024-01-02 09:21:57
• Florfenicol是一种常见得兽用抗生素,能够治疗牛呼吸疾病,在水产养殖业中可以用来控制鲶鱼肠道败血病,同时可以诱导鸡蛋早期胚胎死亡,LC50值为1.07 μg/g。
• 氟苯尼考通过与细菌核糖体上的50S亚基紧密结合，阻碍肽酰基转移酶的转肽反应，从而抑制肽链的延伸；同时选择性地作用于组成细菌菌体的70S核蛋白体的受体，改变和干扰肽酰转移酶的功能，从而双重干扰细菌蛋白质的合成。抗生素类药物，通过抑制肽酰基转移酶活性而产生广谱抑菌作用，抗菌谱广，包括各种革兰氏阳性、阴性菌
  和支原体等。敏感菌包括牛、猪的嗜血杆菌、痢疾志贺氏菌、沙门氏菌、大肠杆菌、肺炎球菌、流感杆菌、
  链球菌、金黄色葡萄球菌、衣原体、钩端螺旋体，立克次氏体等。

名称

• 中文名: 氟苯尼考
• 英文名: florfenicol
• 中文别名: 盐酸阿扑吗啡; 氟比洛芬; 2,2-二氯-N-[(1R,2S)-3-氟-1-羟基-1-(4-甲基磺酰基苯基)-2-丙基]乙酰胺
• 英文别名: Florfenicol; 2R)-1-(fluoromethyl)-2-hydroxy-2-[4-(methanesulfonyl)phenyl]ethyl]acetamide; NUFLOR; 2,2-dichloro-N-[(1S; AQUAFEN; Fluorothiamphenicol; 2,2-DIBROMODECAFLUOROPENTANE; 2,2-Dichloro-N-[(1R,2S)-3-fluoro-1-hydroxy-1-(4-methylsulfonylphenyl)propan-2-yl]acetamide; Florfeniol; Aquaflor; MFCD00864834; EINECS 642-986-0

物化性质

• 密度: 1.5±0.1 g/cm3
• 沸点: 617.5±55.0 °C at 760 mmHg
• 熔点: 153 °C
• 分子式: C₁₂H₁₄Cl₂FNO₄S
• 分子量: 358.213
• 闪点: 327.3±31.5 °C
• 精确质量: 357.000458
• PSA: 91.85000
• LogP: -0.12
• 外观性状: 白色结晶粉末
• 蒸汽压: 0.0±1.9 mmHg at 25°C
• 折射率: 1.548
• 储存条件:

  存放在密封容器内，并放在阴凉，干燥处。

• 稳定性:

  指定条件下稳定，远离氧化物。

• 分子结构:

  1、 摩尔折射率：78.36

  2、 摩尔体积（m³/mol）：246.7

  3、 等张比容（90.2K）：653.2

  4、 表面张力（dyne/cm）：49.1

  5、 极化率（10 ^-24cm ³）：31.06

• 计算化学:

  1.疏水参数计算参考值（XlogP）:无

  2.氢键供体数量:2

  3.氢键受体数量:5

  4.可旋转化学键数量:6

  5.互变异构体数量:2

  6.拓扑分子极性表面积91.8

  7.重原子数量:21

  8.表面电荷:0

  9.复杂度:447

  10.同位素原子数量:0

  11.确定原子立构中心数量:2

  12.不确定原子立构中心数量:0

  13.确定化学键立构中心数量:0

  14.不确定化学键立构中心数量:0

  15.共价键单元数量:1

• 更多:

  1. 性状：固体。

  2. 密度（g/mL,25/4℃）：未确定

  3. 相对蒸汽密度（g/mL,空气=1）：未确定

  4. 熔点（ºC）：153

  5. 沸点（ºC,常压）：未确定

  6. 沸点（ºC,5.2kPa）：未确定

  7. 折射率：未确定

  8. 闪点（ºC）：未确定

  9. 比旋光度（º）：未确定

  10. 自燃点或引燃温度（ºC）：未确定

  11. 蒸气压（kPa,25ºC）：未确定

  12. 饱和蒸气压（kPa,60ºC）：未确定

  13. 燃烧热（KJ/mol）：未确定

  14. 临界温度（ºC）： 未确定

  15. 临界压力（KPa）： 未确定

  16. 油水（辛醇/水）分配系数的对数值：未确定

  17. 爆炸上限（%,V/V）：未确定

  18. 爆炸下限（%,V/V）：未确定

  19. 溶解性：未确定。

生物活性

• 描述: Florfenicol是一种常见得兽用抗生素,能够治疗牛呼吸疾病,在水产养殖业中可以用来控制鲶鱼肠道败血病,同时可以诱导鸡蛋早期胚胎死亡,LC50值为1.07 μg/g。
• 相关类别:
  信号通路 >> 抗感染 >> 细菌
  研究领域 >> 感染
• 参考文献:

  [1]. Al-Shahrani S, et al. Florfenicol induces early embryonic death in eggs collected from treated hens. BMC Vet Res. 2015 Aug 18;11(1):213.

  [2]. Corinna Kehrenberg, et al. A new mechanism for chloramphenicol, florfenicol and clindamycin resistance: methylation of 23S ribosomal RNA at A2503. Molecular Microbiology Volume 57, Issue 4, pages 1064–1073, August 2005

MSDS

Material Safety Data Sheet Section1. Identification of the substance Product Name: Florfenicol Synonyms: Section2. Hazards identification Harmful by inhalation, in contact with skin, and if swallowed. Section3. Composition/information on ingredients. Ingredient name:Florfenicol CAS number:73231-34-2 Section4. First aid measures Skin contact:Immediately wash skin with copious amounts of water for at least 15 minutes while removing contaminated clothing and shoes. If irritation persists, seek medical attention. Eye contact:Immediately wash skin with copious amounts of water for at least 15 minutes. Assure adequate flushing of the eyes by separating the eyelids with fingers. If irritation persists, seek medical attention. Inhalation:Remove to fresh air. In severe cases or if symptoms persist, seek medical attention. Ingestion:Wash out mouth with copious amounts of water for at least 15 minutes. Seek medical attention. Section5. Fire fighting measures In the event of a fire involving this material, alone or in combination with other materials, use dry powder or carbon dioxide extinguishers. Protective clothing and self-contained breathing apparatus should be worn. Section6. Accidental release measures Personal precautions: Wear suitable personal protective equipment which performs satisfactorily and meets local/state/national standards. Respiratory precaution:Wear approved mask/respirator Hand precaution:Wear suitable gloves/gauntlets Skin protection:Wear suitable protective clothing Eye protection:Wear suitable eye protection Methods for cleaning up: Mix with sand or similar inert absorbent material, sweep up and keep in a tightly closed container for disposal. See section 12. Environmental precautions: Do not allow material to enter drains or water courses. Section7. Handling and storage Handling:This product should be handled only by, or under the close supervision of, those properly qualified in the handling and use of potentially hazardous chemicals, who should take into account the fire, health and chemical hazard data given on this sheet. Store in closed vessels, refrigerated. Storage: Section8. Exposure Controls / Personal protection Engineering Controls: Use only in a chemical fume hood. Personal protective equipment: Wear laboratory clothing, chemical-resistant gloves and safety goggles. General hydiene measures: Wash thoroughly after handling. Wash contaminated clothing before reuse. Section9. Physical and chemical properties Appearance:Not specified Boiling point:No data No data Melting point: Flash point:No data Density:No data Molecular formula:C12H14Cl2FNO4S Molecular weight:358.2 Section10. Stability and reactivity Conditions to avoid: Heat, flames and sparks. Materials to avoid: Oxidizing agents. Possible hazardous combustion products: Carbon monoxide, nitrogen oxides, hydrogen chloride, hydrogen fluoride, sulfur oxides. Section11. Toxicological information No data. Section12. Ecological information No data. Section13. Disposal consideration Arrange disposal as special waste, by licensed disposal company, in consultation with local waste disposal authority, in accordance with national and regional regulations. Section14. Transportation information Non-harzardous for air and ground transportation. Section15. Regulatory information No chemicals in this material are subject to the reporting requirements of SARA Title III, Section 302, or have known CAS numbers that exceed the threshold reporting levels established by SARA Title III, Section 313. SECTION 16 - ADDITIONAL INFORMATION N/A

毒性和生态

毒理学数据: 1 、急性毒性：小鼠（静脉）LD50： 100 mg/kg 由于食盐的LD50是3,000 mg/kg，BPA的急性毒性程度与食盐同。 生态学数据: 通常对水是不危害的，若无政府许可，勿将材料排入周围环境。 CHEMICAL IDENTIFICATION RTECS NUMBER : DB6034000 CHEMICAL NAME : Benzenesulfonic acid, 4-(2-((dichloroacetyl)amino)-3-fluoro-1-hydroxypropyl )-, methyl ester, (R-(R*,S*))- CAS REGISTRY NUMBER : 73231-34-2 LAST UPDATED : 198806 DATA ITEMS CITED : 1 MOLECULAR FORMULA : C11-H11-Cl2-F-N2-O4 MOLECULAR WEIGHT : 325.14 WISWESSER LINE NOTATION : WNR DYQY1FMVYGG HEALTH HAZARD DATA ACUTE TOXICITY DATA TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 100 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : DRFUD4 Drugs of the Future. (J.R. Prous, S.A., Apartado de Correos 540, 08080 Barcelona, Spain) V.1- 1975/76- Volume(issue)/page/year: 7,172,1982

安全

• 个人防护装备: Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
• 危害码 (欧洲): Xi: Irritant;
• 风险声明 (欧洲): R36/37/38
• 安全声明 (欧洲): S26-S36
• 危险品运输编码: NONH for all modes of transport
• WGK德国: 3
• 海关编码: 2930909090

合成路线

上下游产品

上游产品  8
535-15-9 116-54-1 76639-93-5 51458-28-7
79-36-7 1069118-16-6 1106981-80-9 1106981-83-2
下游产品  0

海关

海关编码	2930909090
中文概述	2930909090. 其他有机硫化合物. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:30.0%
申报要素	品名, 成分含量, 用途
Summary	2930909090. other organo-sulphur compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%