3344-18-1

• 常用中文名：柠檬酸镁
• 常用英文名：Magnesium citrate
• CAS号：3344-18-1
• 分子式：C₁₂H₁₀Mg₃O₁₄
• 分子量：451.114
• 相关类别： 有机原料 有机金属盐
• 发布时间：2018-08-22 12:42:16
• 更新时间：2024-01-02 13:20:05
• 柠檬酸镁是一种镁盐形式,可有效渗透到大脑和肌肉组织。柠檬酸镁增加痛阈,降低大脑中TLR4的浓度。口服活性[1]。

名称

• 中文名: 柠檬酸镁
• 英文名: Trimagnesium dicitrate
• 中文别名: 2-羟基-1,2,3-丙三羧酸镁盐; 2-羟基-1,2,3-丙三羧酸镁盐(2:3)
• 英文别名: Magnesium citrate; MAGNESIUM CITRATE,TRIBASIC; Citric acid magnesium salt; Tectlol; MFCD00036422; Magcorol P; MagnesiumHydroxideExtraPure; 1,2,3-Propanetricarboxylic acid, 2-hydroxy-, magnesium salt (2:3); Magcorol; Magnesium 2-hydroxy-1,2,3-propanetricarboxylate (3:2); Magnesium citrate (3:2); Magnesium citrate hydrate; EINECS 222-093-9; magnesiumcitrate; trifluoromethylmethane sulfonate; Magnesium 2-hydroxypropane-1,2,3-tricarboxylate (3:2); Trimagnesium dicitrate; MAGNESIUM DI CITRATE

物化性质

• 沸点: 309.6ºC at 760 mmHg
• 分子式: C₁₂H₁₀Mg₃O₁₄
• 分子量: 451.114
• 闪点: 155.2ºC
• 精确质量: 449.962189
• PSA: 198.26000
• 外观性状: 白色或略黄色颗粒粉末
• 储存条件:

  常温， 避光，通风干燥处，密封保存

• 稳定性:

  常温常压下稳定，白色粉末，易溶于水，难溶于乙醇，由于有痕量氢氧化钙存在，水溶液显轻微混浊加热至100℃时逐渐失去结晶水，120℃完全失去。

• 计算化学:

  1、 氢键供体数量：2

  2、 氢键受体数量：14

  3、 可旋转化学键数量：4

  4、 拓扑分子极性表面积（TPSA）：281

  5、 重原子数量：29

  6、 表面电荷：0

  7、 复杂度：211

  8、 同位素原子数量：0

  9、 确定原子立构中心数量：0

  10、 不确定原子立构中心数量：0

  11、 确定化学键立构中心数量：0

  12、 不确定化学键立构中心数量：0

  13、 共价键单元数量：5

• 更多:

  1. 性状：未确定

  2. 密度（g/mL,25/4℃）：未确定

  3. 相对蒸汽密度（g/mL,空气=1）：未确定

  4. 熔点（ºC）：未确定

  5. 沸点（ºC,常压）：未确定

  6. 沸点（ºC,5.2kPa）：未确定

  7. 折射率：未确定

  8. 闪点（ºC）：未确定

  9. 比旋光度（º）：未确定

  10. 自燃点或引燃温度（ºC）：不适用的

  11. 蒸气压（kPa,25ºC）：未确定

  12. 饱和蒸气压（kPa,60ºC）：未确定

  13. 燃烧热（KJ/mol）：未确定

  14. 临界温度（ºC）：未确定

  15. 临界压力（KPa）：未确定

  16. 油水（辛醇/水）分配系数的对数值：未确定

  17. 爆炸上限（%,V/V）：未确定

  18. 爆炸下限（%,V/V）：未确定

  19. 溶解性：未确定

生物活性

• 描述: 柠檬酸镁是一种镁盐形式,可有效渗透到大脑和肌肉组织。柠檬酸镁增加痛阈,降低大脑中TLR4的浓度。口服活性[1]。
• 相关类别:
  信号通路 >> 其他 >> 其他
  研究领域 >> 神经疾病
• 参考文献:

  [1]. Koc B, et al. Magnesium Citrate Increases Pain Threshold and Reduces TLR4 Concentration in the Brain. Biol Trace Elem Res. 2021;199(5):1954-1966.

MSDS

Section 1. Chemical Product and Company Identification Magnesium citrate Common Name/ Trade Name Magnesium citrate Section 4. First Aid Measures Eye ContactCheck for and remove any contact lenses. In case of contact, immediately flush eyes with plenty of water for at least 15 minutes. Cold water may be used. Get medical attention if irritation occurs. Skin ContactWash with soap and water. Cover the irritated skin with an emollient. Get medical attention if irritation develops. Cold water may be used. Serious Skin ContactNot available. InhalationIf inhaled, remove to fresh air. If not breathing, give artificial respiration. If breathing is difficult, give oxygen. Get medical attention. Serious InhalationNot available. IngestionDo NOT induce vomiting unless directed to do so by medical personnel. Never give anything by mouth to an unconscious person. If large quantities of this material are swallowed, call a physician immediately. Loosen tight clothing such as a collar, tie, belt or waistband. Serious IngestionNot available. Section 5. Fire and Explosion Data Flammability of the Product May be combustible at high temperature. Auto-Ignition Temperature Not available. Flash PointsNot available. Flammable LimitsNot available. Products of CombustionThese products are carbon oxides (CO, CO2). Some metallic oxides. Fire Hazards in Presence of Slightly flammable to flammable in presence of heat. Various SubstancesNon-flammable in presence of shocks. Explosion Hazards in Presence Slightly explosive in presence of open flames and sparks. of Various SubstancesNon-explosive in presence of shocks. Fire Fighting MediaSMALL FIRE: Use DRY chemical powder. and InstructionsLARGE FIRE: Use water spray, fog or foam. Do not use water jet. Special Remarks onAs with most organic solids, fire is possible at elevated temperatures Fire Hazards Special Remarks on Explosion Fine dust dispersed in air in sufficient concentrations, and in the presences of an ignition source is a potential Hazardsdust explosion hazard. Section 6. Accidental Release Measures Small SpillUse appropriate tools to put the spilled solid in a convenient waste disposal container. Finish cleaning by spreading water on the contaminated surface and dispose of according to local and regional authority requirements. Large SpillUse a shovel to put the material into a convenient waste disposal container. Finish cleaning by spreading water on the contaminated surface and allow to evacuate through the sanitary system. Section 7. Handling and Storage Keep away from heat. Keep away from sources of ignition. Ground all equipment containing material. Do not Precautions breathe dust. Keep away from incompatibles such as oxidizing agents. StorageKeep container tightly closed. Keep container in a cool, well-ventilated area. Magnesium citrate Section 8. Exposure Controls/Personal Protection Engineering ControlsUse process enclosures, local exhaust ventilation, or other engineering controls to keep airborne levels below recommended exposure limits. If user operations generate dust, fume or mist, use ventilation to keep exposure to airborne contaminants below the exposure limit. Personal ProtectionSafety glasses. Lab coat. Dust respirator. Be sure to use an approved/certified respirator or equivalent. Gloves. Personal Protection in Case of Splash goggles. Full suit. Dust respirator. Boots. Gloves. A self contained breathing apparatus should be a Large Spillused to avoid inhalation of the product. Suggested protective clothing might not be sufficient; consult a specialist BEFORE handling this product. Exposure LimitsNot available. Section 9. Physical and Chemical Properties Physical state and appearance Solid. (Fine Granular solid. Crystalline powder.) OdorOdorless. TasteNot available. Molecular Weight451.13 g/mole x H20 ColorWhite. Off-white. pH (1% soln/water)Not available. Not available. Boiling Point Melting PointNot available. Critical TemperatureNot available. Specific GravityNot available. Vapor PressureNot applicable. Vapor DensityNot available. VolatilityNot available. Not available. Odor Threshold Water/Oil Dist. Coeff.Not available. Ionicity (in Water)Not available. Dispersion PropertiesSee solubility in water. SolubilityPartially soluble in cold water. Section 10. Stability and Reactivity Data StabilityThe product is stable. Instability TemperatureNot available. Conditions of InstabilityExcess heat, dust generation, incompatible materials Reactive with oxidizing agents. Incompatibility with various substances Non-corrosive in presence of glass. Corrosivity Special Remarks onNot available. Reactivity Not available. Special Remarks on Corrosivity PolymerizationWill not occur. Magnesium citrate Section 11. Toxicological Information Routes of EntryInhalation. Ingestion. Toxicity to AnimalsLD50: Not available. LC50: Not available. Chronic Effects on Humans Not available. Other Toxic Effects on Slightly hazardous in case of skin contact (irritant), of ingestion, of inhalation. Humans Special Remarks onNot available. Toxicity to Animals Special Remarks onNot available. Chronic Effects on Humans Special Remarks on otherAcute Potential Health Effects: Toxic Effects on HumansSkin: Contact may cause irritation or rash, particularly with moist skin. Eyes: Dust may cause irritation (abraison) by mechanical action and cause redness, and tearing. Inhalation: Inhalation high concentrations of dust may cause nasal or lung irritation. Ingestion: Ingestion can produce gastrointestinal tract irritation. Can cause diarrhea. Section 12. Ecological Information EcotoxicityNot available. BOD5 and CODNot available. Products of BiodegradationPossibly hazardous short term degradation products are not likely. However, long term degradation products may arise. Toxicity of the ProductsThe product itself and its products of degradation are not toxic. of Biodegradation Special Remarks on theNot available. Products of Biodegradation Section 13. Disposal Considerations Waste DisposalWaste must be disposed of in accordance with federal, state and local environmental control regulations. Section 14. Transport Information DOT ClassificationNot a DOT controlled material (United States). Not applicable. Identification Special Provisions forNot applicable. Transport DOT (Pictograms) Magnesium citrate Section 15. Other Regulatory Information and Pictograms No products were found. Federal and State Regulations CaliforniaCalifornia prop. 65: This product contains the following ingredients for which the State of California has Proposition 65found to cause cancer which would require a warning under the statute: No products were found. Warnings California prop. 65: This product contains the following ingredients for which the State of California has found to cause birth defects which would require a warning under the statute: No products were found. Other RegulationsEINECS: This product is on the European Inventory of Existing Commercial Chemical Substances (EINECS No. 222-093-9). Canada: Listed on Canadian Domestic Substance List (DSL). China: Listed on National Inventory. Japan: Listed on National Inventory (ENCS). Korea: Not listed on National Inventory (KECI). Philippines: Not listed on National Inventory (PICCS). Australia: Listed on AICS. Other ClassificationsWHMIS (Canada) Not controlled under WHMIS (Canada). DSCL (EEC)This product is not classifiedNot applicable. according to the EU regulations. Health Hazard HMIS (U.S.A.)1 National Fire Protection 1 Flammability 1 Association (U.S.A.) Fire Hazard 1 0 Reactivity Health Reactivity 0 Specific hazard Personal Protection E WHMIS (Canada) (Pictograms) DSCL (Europe) (Pictograms) TDG (Canada) (Pictograms) ADR (Europe) (Pictograms) Protective Equipment Gloves. Lab coat. Dust respirator. Be sure to use an approved/certified respirator or equivalent. Magnesium citrate SECTION 16 - ADDITIONAL INFORMATION N/A

毒性和生态

生态学数据: 通常对水是不危害的，若无政府许可，勿将材料排入周围环境

安全

• 危害码 (欧洲): Xi
• 风险声明 (欧洲): R36/37/38
• 安全声明 (欧洲): 26-36
• RTECS号: TZ8552900
• 海关编码: 2918150000

海关

海关编码	2918150000
中文概述	2918150000. 柠檬酸盐和柠檬酸酯. 增值税率:17.0%. 退税率:13.0%. 监管条件:4ABxy(出口许可证,入境货物通关单,出境货物通关单出口许可证(加工贸易),出口许可证(边境小额贸易)). 最惠国关税:6.5%. 普通关税:30.0%
申报要素	品名, 成分含量, 用途
监管条件	4.出口许可证 A.入境货物通关单 B.出境货物通关单 x.出口许可证(加工贸易) y.出口许可证(边境小额贸易)
检验检疫	R.进口食品卫生监督检验 S.出口食品卫生监督检验 N.出口商品检验
Summary	2918150000. other salts and esters of citric acid. VAT:17.0%. Tax rebate rate:13.0%. Supervision conditions:4ABXY(export license,certificate of inspection for goods inward,certificate of inspection for goods outwardexport license(processing trade),export license(border small volume trade)). MFN tariff:6.5%. General tariff:30.0%