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29069-24-7

29069-24-7结构式
29069-24-7结构式

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中文名 泼尼莫司汀
英文名 prednimustine
英文别名 precorrin-6y
3,7,12,17-Corrintetrapropanoic acid,2,8,13,18-tetrakis(carboxymethyl)-7,8,11,12-tetradehydro-9,10,11,22-tetrahydro-3,9,13,18,19-pentamethyl-,(1R-(1alpha,2alpha,3beta,9beta,13alpha,17beta,18alpha,19beta))
描述 泼尼莫司汀(Leo 1031;NSC 134087)是由泼尼松龙(HY-17463)和氯霉素(HY-13593)形成的酯。普尼莫司汀可用于白血病和淋巴瘤研究[1]。
相关类别
体内研究 由于烷基化剂药代动力学的差异,在非荷瘤大鼠模型中,普瑞尼莫司汀(120 mg/kg;皮下注射;单剂量)的毒性远低于等摩尔剂量的氯霉素(HY-13593)(60 mg/kg;单剂量;皮下注射)[1]。普瑞尼莫司汀(40 mg/kg;皮下注射;单次剂量)产生低血浆浓度(小于5μM)的烷基化代谢物氯丁嘧啶和苯乙酸芥,在携带Walker 256癌肉瘤敏感菌株的腹水大鼠中维持48小时[1]。普瑞尼莫司汀(40 mg/kg;皮下注射;单剂量;72小时测量)在吉田肉瘤抗烷基化剂菌株的大鼠模型中显示出抗肿瘤作用[1]。动物模型:非荷瘤雌性Wistar大鼠(150-200g)[1]剂量:120 mg/kg给药:皮下注射;单剂量;结果:大鼠存活率仍为100%,氯霉素治疗组存活率为0%。动物模型:携带吉田肉瘤烷基化剂抗性菌株(150-200g)的雌性Wistar大鼠[1]剂量:40 mg/kg给药:皮下注射;单剂量结果:杀死57%的耐药肿瘤细胞。
密度 1.3g/cm3
沸点 791.5ºC at 760 mmHg
熔点 163-164ºC
分子式 C35H45Cl2NO6
分子量 646.64100
闪点 432.5ºC
精确质量 645.26200
PSA 104.14000
LogP 5.41540
蒸汽压 2.08E-26mmHg at 25°C
折射率 1.606

CHEMICAL IDENTIFICATION

RTECS NUMBER :
TU4153000
CHEMICAL NAME :
Pregna-1,4-diene-3,20-dione, 11-beta,17,21-trihydroxy-, 21-(4-(p-(bis(2-chloroethyl)amino) phenyl)butyrate)
CAS REGISTRY NUMBER :
29069-24-7
LAST UPDATED :
199612
DATA ITEMS CITED :
7
MOLECULAR FORMULA :
C35-H45-Cl2-N-O6
MOLECULAR WEIGHT :
646.71
WISWESSER LINE NOTATION :
L E5 B666 OV AHTTT&J A1 CQ E1 FV1OV3R DN2G2G& FQ

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Human
DOSE/DURATION :
16 mg/kg/4W
TOXIC EFFECTS :
Behavioral - euphoria Blood - leukopenia Blood - thrombocytopenia
REFERENCE :
JNMDBO Journal of Medicine (Westbury, NY). (PJD Pub., Ltd., POB 966, Westbury, NY 11590) V.1- 1970- Volume(issue)/page/year: 8,115,1977
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
530 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
DRFUD4 Drugs of the Future. (J.R. Prous, S.A., Apartado de Correos 540, 08080 Barcelona, Spain) V.1- 1975/76- Volume(issue)/page/year: 1,137,1976
TYPE OF TEST :
LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE :
Subcutaneous
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
128 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
EJCAAH European Journal of Cancer. (Oxford, UK) V.1-17(6), 1965-1981. For publisher information, see EJCODS. Volume(issue)/page/year: 13,873,1977
TYPE OF TEST :
LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE :
Subcutaneous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
128 mg/kg
TOXIC EFFECTS :
Tumorigenic - active as anti-cancer agent
REFERENCE :
EJCAAH European Journal of Cancer. (Oxford, UK) V.1-17(6), 1965-1981. For publisher information, see EJCODS. Volume(issue)/page/year: 13,873,1977 *** REVIEWS *** IARC Cancer Review:Animal Inadequate Evidence IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- Volume(issue)/page/year: 50,115,1990 IARC Cancer Review:Human No Adequate Data IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- Volume(issue)/page/year: 50,115,1990 IARC Cancer Review:Group 3 IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- Volume(issue)/page/year: 50,115,1990