104121-92-8

• 常用中文名：艾地骨化醇
• 常用英文名：Eldecalcitol
• CAS号：104121-92-8
• 分子式：C₃₀H₅₀O₅
• 分子量：490.715
• 相关类别： 信号通路 维生素 D 相关 VD/VDR
• 发布时间：2018-12-17 12:06:41
• 更新时间：2024-01-02 10:30:02
• Eldecalcitol(ED-71; 2.beta.-(3-Hydroxypropoxy)-1.alpha.,25-dihydroxyvitamin D3)是1,25-二羟基维生素D3的类似物。

名称

• 中文名: 1α,25-二羟基-2β-(3-羟基丙氧基)维生素D3
• 英文名: (1S,2S,3S,5Z)-5-[(2E)-2-[(1R,3aS,7aR)-1-[(2R)-6-hydroxy-6-methylheptan-2-yl]-7a-methyl-2,3,3a,5,6,7-hexahydro-1H-inden-4-ylidene]ethylidene]-2-(3-hydroxypropoxy)-4-methylidenecyclohexane-1,3-diol
• 中文别名: 2-(3-羟基丙氧基)-1,25-二羟基维他命D3; 2-(3-羟基丙氧基)-1,25-二羟基维他命D3; 艾地骨化醇
• 英文别名: HY-A0020; ED 71; 9,10-Secocholesta-5,7,10(19)-triene-1,3,25-triol, 2-(3-hydroxypropoxy)-, (1α,2β,3β,5Z,7E)-; UNII-I2JP8UE90H; Eldecalcitol; CS-0363; 1,3-Cyclohexanediol, 2-(3-hydroxypropoxy)-4-methylene-5-[(2E)-2-[(1R,3aS,7aR)-octahydro-1-[(1R)-5-hydroxy-1,5-dimethylhexyl]-7a-methyl-4H-inden-4-ylidene]ethylidene]-, (1R,2R,3R,5Z)-; 1α,25-dihydroxy-2β-(3-hydroxypropoxy)vitamin D3; (1R,2R,3R,5Z,7E)-2-(3-Hydroxypropoxy)-9,10-secocholesta-5,7,10-triene-1,3,25-triol

物化性质

• 密度: 1.1±0.1 g/cm3
• 沸点: 655.7±55.0 °C at 760 mmHg
• 熔点: 126-128ºC
• 分子式: C₃₀H₅₀O₅
• 分子量: 490.715
• 闪点: 350.3±31.5 °C
• 精确质量: 490.365814
• PSA: 90.15000
• LogP: 5.84
• 蒸汽压: 0.0±4.5 mmHg at 25°C
• 折射率: 1.550
• 储存条件: 2-8℃

生物活性

• 描述: Eldecalcitol(ED-71; 2.beta.-(3-Hydroxypropoxy)-1.alpha.,25-dihydroxyvitamin D3)是1,25-二羟基维生素D3的类似物。
• 相关类别:
  信号通路 >> 维生素 D 相关 >> VD/VDR
  研究领域 >> 其他
• 参考文献:

  [1]. Matsumoto T.Osteoporosis Treatment by a New Active Vitamin D3 Compound, Eldecalcitol, in Japan.Curr Osteoporos Rep. 2012 Aug 24.

  [2]. Shiraki M, et al. Eldecalcitol normalizes bone turnover markers regardless of their pre-treatment levels.Curr Med Res Opin. 2012 Aug 23.

  [3]. Matsumoto T, Endo I.Eldecalcitol for the treatment of osteoporosis.Drugs Today (Barc). 2012 Mar;48(3):189-96.

  [4]. Sakai S, et al.Combination therapy with eldecalcitol and alendronate has therapeutic advantages over monotherapy by improving bone strength.Bone. 2012 May;50(5):1054-63. Epub 2012 Feb 17.

  [5]. Sanford M, McCormack PL.Spotlight on eldecalcitol in osteoporosis.Drugs Aging. 2012 Jan 1;29(1):69-71.

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