2413-38-9

• 常用中文名：盐酸氟喷己醇(盐酸氟哌噻吨)
• 常用英文名：Fupentixol dihydrochloride
• CAS号：2413-38-9
• 分子式：C₂₃H₂₇Cl₂F₃N₂OS
• 分子量：507.440
• 相关类别： 原料药 神经系统用药 抗精神病药
• 发布时间：2018-08-31 23:03:28
• 更新时间：2024-01-02 16:55:47
• Flupentixol dihydrochlorid，一种噻克西酮类药物，可用于精神分裂症以及抗焦虑和抑郁障碍的治疗。

名称

• 中文名: 盐酸氟哌噻吨
• 英文名: Fupentixol dihydrochloride
• 中文别名: (Z)-4-[3-[2-(三氟甲基)-9H-硫杂蒽-9-亚基]丙基]-1-哌嗪基乙醇二盐酸盐; 二盐酸氟哌噻吨
• 英文别名: 1-Piperazineethanol, 4-(3-(2-(trifluoromethyl)thioxanthen-9-ylidene)propyl)-, dihydrochloride (8CI); (Z)-4-(3-(2-(Trifluoromethyl)-9H-thioxanthen-9-ylidene)propyl)-1-piperazineethanol dihydrochloride; 1-Piperazineethanol, 4-[3-[2- (trifluoromethyl)-9H-thioxanthen-9-ylidene]propyl]-, dihydrochloride; FUPENTIXOL DIHYDROCHLORIDE; FLUPENTIXOL DIHYDROCHLORIDE; Fluanxol dihydrochloride; 1-Piperazineethanol, 4-[(3Z)-3-[2-(trifluoromethyl)-9H-thioxanthen-9-ylidene]propyl]-, hydrochloride (1:2); 2-(4-{(3Z)-3-[2-(Trifluoromethyl)-9H-thioxanthen-9-ylidene]propyl}-1-piperazinyl)ethanol dihydrochloride; 1-Piperazineethanol, 4-(3-(2-(trifluoromethyl)-9H-thioxanthen-9-ylidene)propyl)-, dihydrochloride (9CI); EINECS 219-321-4; 1-Piperazineethanol, 4-[3-[2- (trifluoromethyl)thioxanthen-9-ylidene]propyl]-, dihydrochloride; 2-(4-{(3Z)-3-[2-(Trifluoromethyl)-9H-thioxanthen-9-ylidene]propyl}piperazin-1-yl)ethanol dihydrochloride; Zimelidine dihydrochloride; Fupentixol HCl; flupentixolhydrochloride; 4-[3-[2-(Trifluoromethyl)-9H-thioxanthen-9-ylidene]propyl]-1-piperazineethanol dihydrochloride; fx703

物化性质

• 沸点: 554.7ºC at 760 mmHg
• 分子式: C₂₃H₂₇Cl₂F₃N₂OS
• 分子量: 507.440
• 闪点: 289.3ºC
• 精确质量: 506.117310
• PSA: 52.01000
• LogP: 6.08150
• 外观性状: 白色或灰白色固体
• 蒸汽压: 3.87E-13mmHg at 25°C
• 储存条件: Desiccate at RT
• 水溶解性: H2O: soluble | soluble

生物活性

• 描述: Flupentixol dihydrochlorid,一种噻克西酮类药物,可用于精神分裂症以及抗焦虑和抑郁障碍的治疗。
• 相关类别:
  信号通路 >> 其他 >> 其他
  研究领域 >> 神经疾病
• 参考文献:

  [1]. Yonar D, et al. Effect of cis-(Z)-flupentixol on DPPC membranes in the presence and absence of cholesterol. Chem Phys Lipids. 2016 Jun;198:61-71.

毒性和生态

CHEMICAL IDENTIFICATION RTECS NUMBER : XO0740000 CHEMICAL NAME : Thioxanthene, 9-(3-(4-(2-hydroxyethyl)piperazinyl)propylidene)-2-tr ifluoromethyl-, dihydrochloride CAS REGISTRY NUMBER : 2413-38-9 LAST UPDATED : 199706 DATA ITEMS CITED : 6 MOLECULAR FORMULA : C23-H25-F3-N2-O-S.2Cl-H MOLECULAR WEIGHT : 507.48 WISWESSER LINE NOTATION : T C666 BS IYJ FXFFF IU3- DT6M DNTJ C2Q &GH 2 HEALTH HAZARD DATA ACUTE TOXICITY DATA TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 791 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: 6,704,1982 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Subcutaneous SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 258 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : IYKEDH Iyakuhin Kenkyu. Study of Medical Supplies. (Nippon Koteisho Kyokai, 12-15, 2-chome, Shibuya, Shibuya-ku, Tokyo 150, Japan) V.1- 1970- Volume(issue)/page/year: 4,90,1973 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 37 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : IYKEDH Iyakuhin Kenkyu. Study of Medical Supplies. (Nippon Koteisho Kyokai, 12-15, 2-chome, Shibuya, Shibuya-ku, Tokyo 150, Japan) V.1- 1970- Volume(issue)/page/year: 4,90,1973 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 423 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : IYKEDH Iyakuhin Kenkyu. Study of Medical Supplies. (Nippon Koteisho Kyokai, 12-15, 2-chome, Shibuya, Shibuya-ku, Tokyo 150, Japan) V.1- 1970- Volume(issue)/page/year: 4,90,1973 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Subcutaneous SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 425 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : IYKEDH Iyakuhin Kenkyu. Study of Medical Supplies. (Nippon Koteisho Kyokai, 12-15, 2-chome, Shibuya, Shibuya-ku, Tokyo 150, Japan) V.1- 1970- Volume(issue)/page/year: 4,90,1973 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 94 mg/kg TOXIC EFFECTS : Behavioral - sleep REFERENCE : APTOA6 Acta Pharmacologica et Toxicologica. (Copenhagen, Denmark) V.1-59, 1945-86. For publisher information, see PHTOEH Volume(issue)/page/year: 19,87,1962

安全

• 危害码 (欧洲): Xn:Harmful;
• 风险声明 (欧洲): R20/21/22
• 安全声明 (欧洲): S36/37/39
• 危险品运输编码: UN 2811
• WGK德国: 3
• RTECS号: TL9900000
• 海关编码: 2942000000

海关

海关编码	2942000000