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41708-76-3生产厂家

41708-76-3价格

41708-76-3

41708-76-3结构式
41708-76-3结构式
  • 常用中文名:Indicine N-oxide
  • 常用英文名:Indicine N-oxide
  • CAS号:41708-76-3
  • 分子式:C15H25NO6
  • 分子量:315.36200
  • 相关类别: 研究领域 癌症
  • 发布时间:2017-11-19 05:11:08
  • 更新时间:2024-01-30 11:05:33
  • 籼N-氧化物(NSC 132319),一种吡咯里西啶生物碱,是儿科癌症和实体瘤研究的抗肿瘤药物[1]。

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中文名 大尾摇碱-N-氧化物
英文名 [(7R,8R)-7-hydroxy-4-oxido-5,6,7,8-tetrahydro-3H-pyrrolizin-4-ium-1-yl]methyl (2R)-2-hydroxy-2-[(1S)-1-hydroxyethyl]-3-methylbutanoate
英文别名 Indicine N-oxide
分子式 C15H25NO6
分子量 315.36200
精确质量 315.16800
PSA 116.42000

CHEMICAL IDENTIFICATION

RTECS NUMBER :
EK7791200
CHEMICAL NAME :
Butanoic acid, 2,3-dihydroxy-2-(1-methylethyl)-, (2,3,5,7a-tetrahydro-1-hydroxy-1H- pyrrolizin-7-yl)methyl ester, N-oxide, (1R-(1-apha,7(2R*,3S),7-a lpha,beta))-
CAS REGISTRY NUMBER :
41708-76-3
LAST UPDATED :
199612
DATA ITEMS CITED :
5
MOLECULAR FORMULA :
C15-H25-N-O6

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
1917 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
NCISP* National Cancer Institute Screening Program Data Summary, Developmental Therapeutics Program. (Bethesda, MD 20205) Volume(issue)/page/year: JAN1986
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
3733 mg/kg
TOXIC EFFECTS :
Behavioral - somnolence (general depressed activity) Lungs, Thorax, or Respiration - respiratory depression Skin and Appendages - hair
REFERENCE :
NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information. Volume(issue)/page/year: PB84-161694
TYPE OF TEST :
LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Mammal - dog
DOSE/DURATION :
1200 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
GVRAAS Government Reports Announcements. (U.S.) (Washington, D.C.) V.71(6) -75(6), 1971-75. Merged with Government Reports Index (US) to form Government Reports Announcement Index (U.S.) Volume(issue)/page/year: 74(9),60,1974 ** OTHER MULTIPLE DOSE TOXICITY DATA **
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
24 gm/kg/4W-I
TOXIC EFFECTS :
Blood - macrocytosis Related to Chronic Data - death
REFERENCE :
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year: 101,271,1989
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
1350 mg/kg/9D-I
TOXIC EFFECTS :
Blood - macrocytosis Related to Chronic Data - death
REFERENCE :
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year: 101,271,1989

危险品运输编码 UN 1544
包装等级 III
危险类别 6.1(b)
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