Shanghai Nianxing Industrial Co., Ltd
China
Product Name: Indicine N-oxide
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Purity: 98.0%
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DC Chemicals Limited
China
Product Name: Indicine N-oxide
Price: ￥Inquiry/1g
Purity: 98.9%
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Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: INDICINE-N-OXIDE
Price: $Inquiry/100g $Inquiry/1kg $Inquiry/100kg $Inquiry/1000kg
Purity: 98.0%
Stocking Period: Inquiry
Contact: Ms Wang

41708-76-3

41708-76-3 structure

Name: Indicine N-oxide
Chemical Name: [(7R,8R)-7-hydroxy-4-oxido-5,6,7,8-tetrahydro-3H-pyrrolizin-4-ium-1-yl]methyl (2R)-2-hydroxy-2-[(1S)-1-hydroxyethyl]-3-methylbutanoate
CAS Number: 41708-76-3
Molecular Formula: C₁₅H₂₅NO₆
Molecular Weight: 315.36200
Catalog: Research Areas Cancer
Create Date: 2017-11-19 05:11:08
Modify Date: 2024-01-30 11:05:33
Indicine N-oxide (NSC 132319), a pyrrolizidine alkaloid, is an antitumor agent for pediatric cancer and solid tumors research[1].

Name	[(7R,8R)-7-hydroxy-4-oxido-5,6,7,8-tetrahydro-3H-pyrrolizin-4-ium-1-yl]methyl (2R)-2-hydroxy-2-[(1S)-1-hydroxyethyl]-3-methylbutanoate
Synonyms	Indicine N-oxide

Description	Indicine N-oxide (NSC 132319), a pyrrolizidine alkaloid, is an antitumor agent for pediatric cancer and solid tumors research[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Others >> Others
References	[1]. V M Whitehead, et al. Phase I trial of indicine-N-oxide in children with leukemia and solid tumors: a Pediatric Oncology Group study. Cancer Chemother Pharmacol. 1990;26(5):377-9. [2]. J S Kovach, et al. Toxicity and pharmacokinetics of a pyrrolizidine alkaloid, indicine N-oxide, in humans. Cancer Res. 1979 Nov;39(11):4540-4.

Molecular Formula	C₁₅H₂₅NO₆
Molecular Weight	315.36200
Exact Mass	315.16800
PSA	116.42000

CHEMICAL IDENTIFICATION

RTECS NUMBER :: EK7791200

CHEMICAL NAME :: Butanoic acid, 2,3-dihydroxy-2-(1-methylethyl)-, (2,3,5,7a-tetrahydro-1-hydroxy-1H- pyrrolizin-7-yl)methyl ester, N-oxide, (1R-(1-apha,7(2R*,3S),7-a lpha,beta))-

CAS REGISTRY NUMBER :: 41708-76-3

LAST UPDATED :: 199612

DATA ITEMS CITED :: 5

MOLECULAR FORMULA :: C15-H25-N-O6

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 1917 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: NCISP* National Cancer Institute Screening Program Data Summary, Developmental Therapeutics Program. (Bethesda, MD 20205) Volume(issue)/page/year: JAN1986

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 3733 mg/kg

TOXIC EFFECTS :: Behavioral - somnolence (general depressed activity) Lungs, Thorax, or Respiration - respiratory depression Skin and Appendages - hair

REFERENCE :: NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information. Volume(issue)/page/year: PB84-161694

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Mammal - dog

DOSE/DURATION :: 1200 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: GVRAAS Government Reports Announcements. (U.S.) (Washington, D.C.) V.71(6) -75(6), 1971-75. Merged with Government Reports Index (US) to form Government Reports Announcement Index (U.S.) Volume(issue)/page/year: 74(9),60,1974 ** OTHER MULTIPLE DOSE TOXICITY DATA **

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 24 gm/kg/4W-I

TOXIC EFFECTS :: Blood - macrocytosis Related to Chronic Data - death

REFERENCE :: TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year: 101,271,1989

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 1350 mg/kg/9D-I

TOXIC EFFECTS :: Blood - macrocytosis Related to Chronic Data - death

REFERENCE :: TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year: 101,271,1989

RIDADR	UN 1544
Packaging Group	III
Hazard Class	6.1(b)

480-82-0

~78%

41708-76-3

Literature: Ogawa, Takeshi; Niwa, Haruki; Yamada, Kiyoyuki Tetrahedron, 1993 , vol. 49, # 8 p. 1571 - 1578

132585-75-2

41708-76-3

Literature: Ogawa, Takeshi; Niwa, Haruki; Yamada, Kiyoyuki Tetrahedron, 1993 , vol. 49, # 8 p. 1571 - 1578

95462-07-0

41708-76-3

Literature: Nishimura; Kondo; Takeuchi; Umezawa Bulletin of the Chemical Society of Japan, 1987 , vol. 60, # 11 p. 4107 - 4113

480-85-3

41708-76-3

Literature: Ogawa, Takeshi; Niwa, Haruki; Yamada, Kiyoyuki Tetrahedron, 1993 , vol. 49, # 8 p. 1571 - 1578

95363-32-9

41708-76-3

Literature: Zalkow; Glinski; Gelbaum; Fleischmann; McGowan; Gordon Journal of Medicinal Chemistry, 1985 , vol. 28, # 6 p. 687 - 694

126453-22-3

41708-76-3

Literature: Ogawa, Takeshi; Niwa, Haruki; Yamada, Kiyoyuki Tetrahedron, 1993 , vol. 49, # 8 p. 1571 - 1578

126331-49-5

41708-76-3

Literature: Ogawa, Takeshi; Niwa, Haruki; Yamada, Kiyoyuki Tetrahedron, 1993 , vol. 49, # 8 p. 1571 - 1578

Precursor 3
480-82-0 132585-75-2 480-85-3
DownStream 0

41708-76-3	20267-93-0
133352-27-9	95462-14-9
86639-48-7	71539-52-1
90503-56-3	72962-60-8
84940-63-6	603137-43-5
1158522-08-7	940364-43-2
134104-43-1	131615-57-1
6906-52-1	930439-75-1
1018584-77-4	1375289-11-4
849349-65-1	127437-46-1