55658-47-4

• 常用中文名：盐酸平阳霉素
• 常用英文名：Bleomycin A5 (hydrochloride)
• CAS号：55658-47-4
• 分子式：C₅₇H₉₀ClN₁₉O₂₁S₂
• 分子量：1477.02
• 相关类别： 原料药 抗肿瘤药 抗生素类抗肿瘤药
• 发布时间：2018-03-12 08:00:00
• 更新时间：2024-01-02 17:40:30
• 博莱霉素A5盐酸盐是一种抗肿瘤糖蛋白抗生素。博莱霉素A5抑制Drp1介导的线粒体分裂并诱导人鼻息肉源性成纤维细胞凋亡[1][2]。

名称

• 中文名: 盐酸平阳霉素
• 英文名: bleocin(tm), streptomyces verticillus
• 英文别名: BLEOCIN(TM) ANTIBIOTIC; n(sup1)-(3-((4-aminobutyl)amino)propyl)-bleomycinamidhydrochloride; N1-[3-[(4-Aminobutyl)amino]propyl]bleomycinamide hydrochloride; n(sup1)-(3-((4-aminobutyl)amino)propyl)bleomycinamidehydrochloride; BleoMycin A5 Hydrochloride(PingyangMycin hydrochloride); Bleomycin A5 Hydrochloride; BLEOCIN(TM)

物化性质

• 密度: 1.56g/cm3
• 分子式: C₅₇H₉₀ClN₁₉O₂₁S₂
• 分子量: 1477.02
• 精确质量: 1475.57000
• PSA: 721.60000
• 储存条件: 2-8C

生物活性

• 描述: 博莱霉素A5盐酸盐是一种抗肿瘤糖蛋白抗生素。博莱霉素A5抑制Drp1介导的线粒体分裂并诱导人鼻息肉源性成纤维细胞凋亡[1][2]。
• 相关类别:
  信号通路 >> 细胞凋亡 >> 细胞凋亡
  研究领域 >> 癌症
  研究领域 >> 感染
• 参考文献:

  [1]. Yang LC, et al. MEK inhibition enhances bleomycin A5-induced apoptosis in an oral cancer cell line: signaling mechanisms and therapeutic opportunities. J Oral Pathol Med. 2004;33(1):37-45.

  [2]. Wu F, et al. Bleomycin A5 suppresses Drp1 mediated mitochondrial fission and induces apoptosis in human nasal polyp derived fibroblasts. Int J Mol Med. 2021;47(1):346-360.

  [3]. Pan JB, et al. Rolipram attenuates bleomycin A5-induced pulmonary fibrosis in rats. Respirology. 2009;14(7):975-982.

毒性和生态

CHEMICAL IDENTIFICATION RTECS NUMBER : EC5990700 CHEMICAL NAME : Bleomycinamide, N(sup 1)-(3-((4-aminobutyl)amino)propyl)-, hydrochloride CAS REGISTRY NUMBER : 55658-47-4 LAST UPDATED : 199603 DATA ITEMS CITED : 10 MOLECULAR FORMULA : C57-H89-N19-O21-S2.Cl-H MOLECULAR WEIGHT : 1477.23 HEALTH HAZARD DATA ACUTE TOXICITY DATA TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 117 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : ANTBAL Antibiotiki. (Moscow, USSR) V.1-29, 1956-84. For publisher information, see AMBIEH. Volume(issue)/page/year: 24,363,1979 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 75 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : ANTBAL Antibiotiki. (Moscow, USSR) V.1-29, 1956-84. For publisher information, see AMBIEH. Volume(issue)/page/year: 24,363,1979 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intramuscular SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 102 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : ANTBAL Antibiotiki. (Moscow, USSR) V.1-29, 1956-84. For publisher information, see AMBIEH. Volume(issue)/page/year: 24,363,1979 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 800 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : ANTBAL Antibiotiki. (Moscow, USSR) V.1-29, 1956-84. For publisher information, see AMBIEH. Volume(issue)/page/year: 24,363,1979 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 66 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : ANTBAL Antibiotiki. (Moscow, USSR) V.1-29, 1956-84. For publisher information, see AMBIEH. Volume(issue)/page/year: 24,363,1979 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Subcutaneous SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 67 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : ANTBAL Antibiotiki. (Moscow, USSR) V.1-29, 1956-84. For publisher information, see AMBIEH. Volume(issue)/page/year: 24,363,1979 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 50 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : ANTBAL Antibiotiki. (Moscow, USSR) V.1-29, 1956-84. For publisher information, see AMBIEH. Volume(issue)/page/year: 24,175,1979 ** OTHER MULTIPLE DOSE TOXICITY DATA ** TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Intramuscular SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 40 mg/kg/8W-I TOXIC EFFECTS : Liver - changes in liver weight Blood - changes in other cell count (unspecified) Nutritional and Gross Metabolic - weight loss or decreased weight gain REFERENCE : ANTBAL Antibiotiki. (Moscow, USSR) V.1-29, 1956-84. For publisher information, see AMBIEH. Volume(issue)/page/year: 24,847,1979 TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Mammal - dog DOSE/DURATION : 35 mg/kg/3W-I TOXIC EFFECTS : Lungs, Thorax, or Respiration - other changes Kidney, Ureter, Bladder - changes primarily in glomeruli REFERENCE : ANTBAL Antibiotiki. (Moscow, USSR) V.1-29, 1956-84. For publisher information, see AMBIEH. Volume(issue)/page/year: 24,847,1979 TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Rodent - rabbit DOSE/DURATION : 40 mg/kg/2W-I TOXIC EFFECTS : Lungs, Thorax, or Respiration - other changes Blood - changes in serum composition (e.g. TP, bilirubin, cholesterol) Related to Chronic Data - death REFERENCE : ANTBAL Antibiotiki. (Moscow, USSR) V.1-29, 1956-84. For publisher information, see AMBIEH. Volume(issue)/page/year: 24,847,1979