64925-80-0

• 常用中文名：Phomopsin A
• 常用英文名：Phomopsin A
• CAS号：64925-80-0
• 分子式：C₃₆H₄₅ClN₆O₁₂
• 分子量：789.22800
• 相关类别： 信号通路 细胞周期/DNA损伤 微管/微管蛋白
• 发布时间：2016-08-27 00:06:56
• 更新时间：2024-01-08 18:00:39
• Phomopsin A 是一种从真菌 Phomopsis leptostomiformis 分离的环状六肽霉菌毒素。Phomopsin A 是放射性标记的长春新碱与微管蛋白结合的非竞争性抑制剂。

名称

• 中文名: 噬菌素A
• 英文名: phomopsin a
• 英文别名: phomopsin a from phomopsis leptostromiformis; phomopsin; PMSA

物化性质

• 密度: 1.48g/cm3
• 沸点: 1188.2ºC at 760 mmHg
• 分子式: C₃₆H₄₅ClN₆O₁₂
• 分子量: 789.22800
• 闪点: 672.4ºC
• 精确质量: 788.27800
• PSA: 273.03000
• LogP: 2.27850
• 折射率: 1.655
• 储存条件: 2-8°C，密封，干燥

生物活性

• 描述: Phomopsin A 是一种从真菌 Phomopsis leptostomiformis 分离的环状六肽霉菌毒素。Phomopsin A 是放射性标记的长春新碱与微管蛋白结合的非竞争性抑制剂。
• 相关类别:
  研究领域 >> 癌症
  信号通路 >> 细胞周期/DNA损伤 >> 微管/微管蛋白
  信号通路 >> 细胞骨架 >> 微管/微管蛋白
• 参考文献:

  [1]. Hamel E, et al. Natural products which interact with tubulin in the vinca domain: maytansine, rhizoxin, phomopsin A, dolastatins 10 and 15 and halichondrin B. Pharmacol Ther. 1992;55(1):31-51.

毒性和生态

CHEMICAL IDENTIFICATION RTECS NUMBER : SY2593000 CHEMICAL NAME : Phomopsin A CAS REGISTRY NUMBER : 64925-80-0 LAST UPDATED : 199801 HEALTH HAZARD DATA ACUTE TOXICITY DATA TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Unreported SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 5 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Subcutaneous SPECIES OBSERVED : Mammal - domestic DOSE/DURATION : 10 ug/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value TYPE OF TEST : LDLo - Lowest published lethal dose ROUTE OF EXPOSURE : Parenteral SPECIES OBSERVED : Mammal - domestic DOSE/DURATION : 1 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Parenteral SPECIES OBSERVED : Mammal - domestic DOSE/DURATION : 1 mg/kg/1W-I TOXIC EFFECTS : Behavioral - food intake (animal) Liver - other changes Related to Chronic Data - death TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Parenteral SPECIES OBSERVED : Mammal - domestic DOSE/DURATION : 1 mg/kg/4W-I TOXIC EFFECTS : Behavioral - somnolence (general depressed activity) Behavioral - food intake (animal) Liver - jaundice (or hyperbilirubinemia) hepatocellular TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Intraperitoneal DOSE : 150 ug/kg SEX/DURATION : female 6-10 day(s) after conception TOXIC EFFECTS : Reproductive - Fertility - post-implantation mortality (e.g. dead and/or resorbed implants per total number of implants) TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Intraperitoneal DOSE : 400 ug/kg SEX/DURATION : female 6 day(s) after conception TOXIC EFFECTS : Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death, e.g., stunted fetus) MUTATION DATA TYPE OF TEST : Cytogenetic analysis TEST SYSTEM : Rodent - hamster Lung DOSE/DURATION : 10 mg/L REFERENCE : CYTBAI Cytobios. (Faculty Press, 88 Regent St., Cambridge, UK) V.1- 1969- Volume(issue)/page/year: 46,79,1986

安全

• 危害码 (欧洲): Xn: Harmful;
• 风险声明 (欧洲): 20/21/22-40