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58337-35-2

58337-35-2结构式

常用中文名：依利醋铵
常用英文名：H9M2E
CAS号：58337-35-2
分子式：C₂₀H₂₀N₂O₃
分子量：336.38400
相关类别：研究领域癌症
发布时间：2018-07-03 18:52:21
更新时间：2024-01-20 15:09:51
乙酸椭圆体(NSC 264137)是一种DNA插入剂,对L1210细胞具有高度细胞毒性,并与L1210细胞的核酸共价结合。醋酸Elliptium可用于癌症研究,尤其是转移性乳腺癌[1][2]。

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中文名	依利醋铵
英文名	2,5,11-trimethyl-6H-pyrido[4,3-b]carbazol-2-ium-9-ol,acetate
英文别名	ELLIPTINIUM ACETATE Ellipticine acetomethylate 9-hydroxy-2-methylellipticinium acetate elliptinium Elliptinii acetas [INN-Latin] EINECS 261-216-0 Acetato de eliptinio [INN-Spanish] Acetate d'elliptinium [INN-French] Celiptium 9-hydroxy-N-2-methylellipticinium acetate Elliptinium acetate [INN:BAN] N2-Methylhydroxyellipticinium acetate N2-methyl-9-hydroxyellipticinium acetate

描述	乙酸椭圆体(NSC 264137)是一种DNA插入剂,对L1210细胞具有高度细胞毒性,并与L1210细胞的核酸共价结合。醋酸Elliptium可用于癌症研究,尤其是转移性乳腺癌[1][2]。
相关类别	研究领域 >> 癌症
靶点	Nucleic acids[1][2].
体外研究	Elliptium(0.35µM；1 h)(9-OH-NME3)显示出与L1210细胞的核酸高度稳定的共价键合[1]。细胞活力测定[1]细胞系：L1 210细胞浓度：0.35µM培养时间：1小时结果：显示出与DNA和RNA高度稳定的共价键。当细胞在40h期间继续复制时,结合没有逆转。

分子式	C₂₀H₂₀N₂O₃
分子量	336.38400
精确质量	336.14700
PSA	80.03000
LogP	2.37740

CHEMICAL IDENTIFICATION

RTECS NUMBER :: UU8875500

CHEMICAL NAME :: 6H-Pyrido(4,3-b)carbazolium, 9-hydroxy-2,5,11-trimethyl-, acetate

CAS REGISTRY NUMBER :: 58337-35-2

LAST UPDATED :: 199609

DATA ITEMS CITED :: 9

MOLECULAR FORMULA :: C18-H17-N2-O.C2-H3-O2

MOLECULAR WEIGHT :: 336.42

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 33 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 18 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 10200 ug/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 8 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 40 mg/kg/8W-I

TOXIC EFFECTS :: Kidney, Ureter, Bladder - changes in tubules (including acute renal failure, acute tubular necrosis) Kidney, Ureter, Bladder - changes in bladder weight Nutritional and Gross Metabolic - weight loss or decreased weight gain

TYPE OF TEST :: Micronucleus test

MUTATION DATA

TEST SYSTEM :: Rodent - mouse

DOSE/DURATION :: 10 mg/kg

REFERENCE :: TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year: 89,281,1987

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