4267-47-4

• 常用中文名：PF-63
• 常用英文名：PF-63
• CAS号：4267-47-4
• 分子式：C₄₃H₅₈N₂O₁₂
• 分子量：794.92700
• 发布时间：2016-10-12 00:22:23
• 更新时间：2024-04-03 10:27:29

名称

• 英文名: 3-piperidin-1-ylmethyl-rifamycin
• 英文别名: 3-Piperidinomethyl-rifamycin SV; 3-(piperidin-1-yl-methyl)aniline; 3-(Piperidylmethyl)phenylamine; [3-(piperidin-1-ylmethyl)phenyl]amine; 3-(piperidinomethyl)benzenamine; 3-piperidinomethyl-aniline; 3-Piperidinomethyl-anilin

物化性质

• 密度: 1.33g/cm3
• 沸点: 899.9ºC at 760 mmHg
• 分子式: C₄₃H₅₈N₂O₁₂
• 分子量: 794.92700
• 闪点: 498.1ºC
• 精确质量: 794.39900
• PSA: 204.55000
• LogP: 5.81590
• 折射率: 1.631

毒性和生态

CHEMICAL IDENTIFICATION RTECS NUMBER : KD1920900 CHEMICAL NAME : 2,7-(Epoxypentadeca(1,11,13)trienimino)naphtho(2,1-b) furan-1,11(2H)-dione, 5,6,9,17,19,21- hexahydroxy-2,4,12,16,18,20,22-heptamethyl-23-methoxy -8-(piperidinomethyl) -, 21-acetate CAS REGISTRY NUMBER : 4267-47-4 LAST UPDATED : 199712 DATA ITEMS CITED : 2 MOLECULAR FORMULA : C43-H58-N2-O12 MOLECULAR WEIGHT : 795.03 HEALTH HAZARD DATA ACUTE TOXICITY DATA TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 1700 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : CMTRAG Chemotherapia. (Basel, Switzerland) V.1-12, 1960-67. For publisher information, see CHTHBK. Volume(issue)/page/year: 12,155,1967 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 183 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : 38KLAC "Structure-Activity Relationship among the Semisynthetic Antibiotics," Perlman, D., ed., New York, Academic Press, 1977 Volume(issue)/page/year: -,531,1977

合成路线

110-89-4 50-00-0 62623-68-1 ~% 4267-47-4

文献：Maggi; Arioli; Sensi Journal of medicinal chemistry, 1965 , vol. 8, # 6 p. 790 - 793

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