PF-63

Modify Date: 2024-04-03 10:27:29

PF-63 Structure
PF-63 structure
Common Name PF-63
CAS Number 4267-47-4 Molecular Weight 794.92700
Density 1.33g/cm3 Boiling Point 899.9ºC at 760 mmHg
Molecular Formula C43H58N2O12 Melting Point N/A
MSDS N/A Flash Point 498.1ºC

 Names

Name 3-piperidin-1-ylmethyl-rifamycin
Synonym More Synonyms

 Chemical & Physical Properties

Density 1.33g/cm3
Boiling Point 899.9ºC at 760 mmHg
Molecular Formula C43H58N2O12
Molecular Weight 794.92700
Flash Point 498.1ºC
Exact Mass 794.39900
PSA 204.55000
LogP 5.81590
Index of Refraction 1.631

 Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
KD1920900
CHEMICAL NAME :
2,7-(Epoxypentadeca(1,11,13)trienimino)naphtho(2,1-b) furan-1,11(2H)-dione, 5,6,9,17,19,21- hexahydroxy-2,4,12,16,18,20,22-heptamethyl-23-methoxy -8-(piperidinomethyl) -, 21-acetate
CAS REGISTRY NUMBER :
4267-47-4
LAST UPDATED :
199712
DATA ITEMS CITED :
2
MOLECULAR FORMULA :
C43-H58-N2-O12
MOLECULAR WEIGHT :
795.03

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
1700 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
CMTRAG Chemotherapia. (Basel, Switzerland) V.1-12, 1960-67. For publisher information, see CHTHBK. Volume(issue)/page/year: 12,155,1967
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
183 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
38KLAC "Structure-Activity Relationship among the Semisynthetic Antibiotics," Perlman, D., ed., New York, Academic Press, 1977 Volume(issue)/page/year: -,531,1977

 Synthetic Route

~%

PF-63 Structure

PF-63

CAS#:4267-47-4

Literature: Maggi; Arioli; Sensi Journal of medicinal chemistry, 1965 , vol. 8, # 6 p. 790 - 793

 Synonyms

3-Piperidinomethyl-rifamycin SV
3-(piperidin-1-yl-methyl)aniline
3-(Piperidylmethyl)phenylamine
[3-(piperidin-1-ylmethyl)phenyl]amine
3-(piperidinomethyl)benzenamine
3-piperidinomethyl-aniline
3-Piperidinomethyl-anilin