66611-26-5

• 常用中文名：5-甲氧基-3-(1,2,3,6-四氢吡啶-4-基)-1H-吲哚
• 常用英文名：RU 24969
• CAS号：66611-26-5
• 分子式：C₁₄H₁₆N₂O
• 分子量：228.29000
• 相关类别： 信号通路 G 蛋白偶联受体/G 蛋白 5-HT受体
• 发布时间：2018-12-31 01:30:26
• 更新时间：2024-01-09 16:55:57
• RU 24969是5-HT1A和5-HT1B受体的选择性激动剂。

名称

• 中文名: 5-甲氧基-3-(1,2,3,6-四氢-4-吡啶)-1H-吲哚
• 英文名: 5-methoxy-3-(1,2,3,6-tetrahydropyridin-4-yl)-1H-indole
• 英文别名: Tocris-0912; RU 24969

物化性质

• 分子式: C₁₄H₁₆N₂O
• 分子量: 228.29000
• 精确质量: 228.12600
• PSA: 37.05000
• LogP: 2.88200
• 储存条件: 2-8℃

生物活性

• 描述: RU 24969是5-HT1A和5-HT1B受体的选择性激动剂。
• 相关类别:
  信号通路 >> G 蛋白偶联受体/G 蛋白 >> 5-HT受体
  信号通路 >> 神经信号通路 >> 5-HT受体
  研究领域 >> 神经疾病
• 参考文献:

  [1]. Doods HN, et al. Differential selectivities of RU 24969 and 8-OH-DPAT for the purported 5-HT1A and 5-HT1B binding sites. Correlation between 5-HT1A affinity and hypotensive activity. Eur J Pharmacol. 1985 Jun 19;112(3):363-70.

  [2]. Green AR, et al. The behavioural effects of RU 24969, a suggested 5-HT1 receptor agonist in rodents and the effect on the behaviour of treatment with antidepressants. Neuropharmacology. 1984 Jun;23(6):655-61.

  [3]. Aronsen D, et al. RU 24969-produced adipsia and hyperlocomotion: Differential role of 5HT1A and 5HT1B receptor mechanisms. Pharmacol Biochem Behav. 2014 May 15;124C:1-4.

  [4]. Cheetham SC, et al. Evidence that RU 24969-induced locomotor activity in C57/B1/6 mice is specifically mediated by the 5-HT1B receptor. Br J Pharmacol. 1993 Dec;110(4):1621-9.

安全

• 海关编码: 2933990090

合成路线

1006-94-6 41979-39-9 ~88% 66611-26-5

文献：BIO-MEDISINSK INNOVASJON AS; COCKBAIN, Julian Patent: WO2007/7072 A1, 2007 ; Location in patent: Page/Page column 21-22 ; WO 2007/007072 A1

1006-94-6 40064-34-4 ~% 180160-69-4 66611-26-5

文献：Eli Lilly and Company Patent: US5614523 A1, 1997 ; US 5614523 A

1006-94-6 40064-34-4 ~% 66611-26-5

文献：Eli Lilly and Company Patent: US5846982 A1, 1998 ; US 5846982 A

41661-47-6 1006-94-6 ~% 66611-26-5

文献：Mattsson, Cecilia; Sonesson, Clas; Sandahl, Anna; Greiner, Hartmut E.; Gassen, Michael; Plaschke, Joerg; Leibrock, Joachim; Boettcher, Henning Bioorganic and Medicinal Chemistry Letters, 2005 , vol. 15, # 19 p. 4230 - 4234

上下游产品

上游产品  4
1006-94-6 41979-39-9 40064-34-4 41661-47-6
下游产品  1
52157-82-1

海关

海关编码	2933990090
中文概述	2933990090. 其他仅含氮杂原子的杂环化合物. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:20.0%
申报要素	品名, 成分含量, 用途, 乌洛托品请注明外观, 6－己内酰胺请注明外观, 签约日期
Summary	2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%