55837-19-9

• 常用中文名：已丙洛尔
• 常用英文名：Exaprolol
• CAS号：55837-19-9
• 分子式：C₁₈H₂₉NO₂
• 分子量：291.42800
• 发布时间：2018-09-17 05:15:08
• 更新时间：2024-01-04 16:42:21

名称

• 中文名: 已丙洛尔
• 英文名: 1-(2-cyclohexylphenoxy)-3-(propan-2-ylamino)propan-2-ol
• 英文别名: exaprolol; Exaprolol [INN]; Exaprololum [INN-Latin]; 2-Propanol,1-(2-cyclohexylphenoxy)-3-((1-methylethyl)amino); 1-(2-Cyclohexylphenoxy)-3-((1-methylethyl)amino)-2-propanol; 1-Isopropylamino-3-(2-cyclohexylphenoxy)-2-propanol; 1-(O-Cyklohexyl)fenoxy-3-izopropyl(aminopropan-1-ol) [Czech]; Esaprololo [DCIT]; Vulm 111

物化性质

• 密度: 1.025g/cm3
• 沸点: 445.2ºC at 760 mmHg
• 分子式: C₁₈H₂₉NO₂
• 分子量: 291.42800
• 闪点: 223.1ºC
• 精确质量: 291.22000
• PSA: 41.49000
• LogP: 3.86290
• 折射率: 1.524

毒性和生态

CHEMICAL IDENTIFICATION RTECS NUMBER : UA9812800 CHEMICAL NAME : 2-Propanol, 1-(2-cyclohexylphenoxy)-3-((1-methylethyl)amino)- CAS REGISTRY NUMBER : 55837-19-9 LAST UPDATED : 199612 DATA ITEMS CITED : 2 MOLECULAR FORMULA : C18-H29-N-O2 MOLECULAR WEIGHT : 291.48 HEALTH HAZARD DATA ACUTE TOXICITY DATA TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Oral DOSE : 65 mg/kg SEX/DURATION : female 4-16 day(s) after conception TOXIC EFFECTS : Reproductive - Specific Developmental Abnormalities - musculoskeletal system REFERENCE : BLLIAX Bratislavske Lekarske Listy. (PNS-Ustredna Expedicia a Dovoz Tlace, Gottwaldovo nam. 6, 813 81 Bratislava, Czechoslovakia) V.1- 1921- Volume(issue)/page/year: 76,664,1981 TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Oral DOSE : 130 mg/kg SEX/DURATION : female 4-16 day(s) after conception TOXIC EFFECTS : Reproductive - Specific Developmental Abnormalities - musculoskeletal system REFERENCE : BLLIAX Bratislavske Lekarske Listy. (PNS-Ustredna Expedicia a Dovoz Tlace, Gottwaldovo nam. 6, 813 81 Bratislava, Czechoslovakia) V.1- 1921- Volume(issue)/page/year: 76,664,1981

合成路线

67006-90-0 75-31-0 ~% 55837-19-9

文献：Jendrichovsky; Rybar; Stibranyi; et al. Collection of Czechoslovak Chemical Communications, 1978 , vol. 43, # 4 p. 1100 - 1107

119-42-6 75-31-0 106-89-8 ~% 55837-19-9

文献：Carissimi; Gentili; Grumelli; Milla; Picciola; Ravenna Arzneimittel-Forschung/Drug Research, 1976 , vol. 26, # 4 p. 506 - 516

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