2566-89-4

• 常用中文名：花生四烯酸甲酯
• 常用英文名：Methyl (5Z,8Z,11Z,14Z)-5,8,11,14-icosatetraenoate
• CAS号：2566-89-4
• 分子式：C₂₁H₃₄O₂
• 分子量：318.493
• 相关类别： 分析化学 食品安全 脂肪酸、脂肪酸甲酯
• 发布时间：2018-06-11 17:52:27
• 更新时间：2024-01-10 00:54:08
• 花生四烯酸甲酯(花生四烯酸甲基酯)是一种脂肪酸甲基酯,由花生四烯酸的羧基与甲醇正式缩合而成。花生四烯酸甲酯具有人血清代谢产物的活性[1]。

名称

• 中文名: 花生四烯酸甲酯
• 英文名: methyl arachidonate
• 中文别名: 花生四烯酸甲基酯
• 英文别名: 5,8,11,14-Eicosatetraenoic acid, methyl ester, (5Z,8Z,11Z,14Z)-; EINECS 219-900-1; 5,8,11,14-Eicosatetraenoic acid, methyl ester, (all-Z)-; Methyl (5Z,8Z,11Z,14Z)-5,8,11,14-icosatetraenoate; Methyl arachidonate; Arachidonic acid methyl ester; Methyl (5Z,8Z,11Z,14Z)-icosa-5,8,11,14-tetraenoate; MFCD00016775

物化性质

• 密度: 0.9±0.1 g/cm3
• 沸点: 403.9±34.0 °C at 760 mmHg
• 分子式: C₂₁H₃₄O₂
• 分子量: 318.493
• 闪点: 102.0±24.0 °C
• 精确质量: 318.255890
• PSA: 26.30000
• LogP: 7.47
• 外观性状: Liquid
• 蒸汽压: 0.0±0.9 mmHg at 25°C
• 折射率: 1.486
• 储存条件:

  充氩密封-18℃以下干燥避光保存

• 稳定性:

  1. 如果遵照规格使用和储存则不会分解。

  2. 存在于烟叶中。

• 水溶解性: chloroform: 50 mg/mL, clear, colorless
• 分子结构:

  1、 摩尔折射率：101.34

  2、 摩尔体积（cm³/mol）：353.1

  3、 等张比容（90.2K）：841.2

  4、 表面张力（dyne/cm）：32.2

  5、 极化率（10^-24cm³）：40.17

• 计算化学:

  1、 疏水参数计算参考值（XlogP）：6.6

  2、 氢键供体数量：0

  3、 氢键受体数量：2

  4、 可旋转化学键数量：15

  5、 拓扑分子极性表面积（TPSA）：26.3

  6、 重原子数量：23

  7、 表面电荷：0

  8、 复杂度：375

  9、 同位素原子数量：0

  10、 确定原子立构中心数量：0

  11、 不确定原子立构中心数量：0

  12、 确定化学键立构中心数量：4

  13、 不确定化学键立构中心数量：0

  14、 共价键单元数量：1

• 更多:

  1. 性状：液体对湿和空气敏感。

  2. 密度（g/mL,20/4℃）： 0.901

  3. 相对蒸汽密度（g/mL,空气=1）：未确定

  4. 熔点（ºC）：未确定

  5. 沸点（ºC,常压）：200-205（0.27kPa），127-128（0.0001kPa）

  6. 沸点（ºC,5.2kPa）：403.9

  7. 折射率：(nD/20)1.4797-1.4810易燃

  8. 闪点（ºC）：102

  9. 比旋光度（º）：未确定

  10. 自燃点或引燃温度（ºC）：未确定

  11. 蒸气压（kPa,25ºC）：未确定

  12. 饱和蒸气压（kPa,60ºC）：未确定

  13. 燃烧热（KJ/mol）：未确定

  14. 临界温度（ºC）：未确定

  15. 临界压力（KPa）：未确定

  16. 油水（辛醇/水）分配系数的对数值：未确定

  17. 爆炸上限（%,V/V）：未确定

  18. 爆炸下限（%,V/V）：未确定

  19. 溶解性：未确定

生物活性

• 描述: 花生四烯酸甲酯(花生四烯酸甲基酯)是一种脂肪酸甲基酯,由花生四烯酸的羧基与甲醇正式缩合而成。花生四烯酸甲酯具有人血清代谢产物的活性[1]。
• 相关类别:
  信号通路 >> 其他 >> 其他
  研究领域 >> 代谢疾病
• 参考文献:

  [1]. White, Mary F, et al. The application of the polybromide yield in the estimation of methyl arachidonate in the methyl ester mixtures. Journal of the American Oil Chemists' Society. Volume: 26. Pages: 85-90. Journal.1949.

MSDS

SECTION 1: Identification of the substance/mixture and of the company/undertaking Product identifiers Product name: Methyl arachidonate REACH No.: A registration number is not available for this substance as the substance or its uses are exempted from registration, the annual tonnage does not require a registration or the registration is envisaged for a later registration deadline. CAS-No.: 2566-89-4 Relevant identified uses of the substance or mixture and uses advised against Identified uses: Laboratory chemicals, Manufacture of substances SECTION 2: Hazards identification Classification of the substance or mixture Classification according to Regulation (EC) No 1272/2008 Self-heating substances and mixtures (Category 2), H252 For the full text of the H-Statements mentioned in this Section, see Section 16. Not a hazardous substance or mixture according to EC-directives 67/548/EEC or 1999/45/EC. Label elements Labelling according Regulation (EC) No 1272/2008 Pictogram Signal wordWarning Hazard statement(s) H252Self-heating in large quantities; may catch fire. Precautionary statement(s) P235 + P410Keep cool. Protect from sunlight. Supplemental Hazardnone Statements Other hazards This substance/mixture contains no components considered to be either persistent, bioaccumulative and toxic (PBT), or very persistent and very bioaccumulative (vPvB) at levels of 0.1% or higher. SECTION 3: Composition/information on ingredients Substances Synonyms: Arachidonic acid methyl ester Formula: C21H34O2 Molecular weight: 318,49 g/mol CAS-No.: 2566-89-4 No components need to be disclosed according to the applicable regulations. For the full text of the H-Statements and R-Phrases mentioned in this Section, see Section 16 SECTION 4: First aid measures Description of first aid measures General advice Consult a physician. Show this safety data sheet to the doctor in attendance. If inhaled If breathed in, move person into fresh air. If not breathing, give artificial respiration. Consult a physician. In case of skin contact Wash off with soap and plenty of water. Consult a physician. In case of eye contact Flush eyes with water as a precaution. If swallowed Never give anything by mouth to an unconscious person. Rinse mouth with water. Consult a physician. Most important symptoms and effects, both acute and delayed The most important known symptoms and effects are described in the labelling (see section 2.2) and/or in section 11 Indication of any immediate medical attention and special treatment needed No data available SECTION 5: Firefighting measures Extinguishing media Suitable extinguishing media Use water spray, alcohol-resistant foam, dry chemical or carbon dioxide. Special hazards arising from the substance or mixture Carbon oxides Advice for firefighters Wear self-contained breathing apparatus for firefighting if necessary. Further information Use water spray to cool unopened containers. SECTION 6: Accidental release measures Personal precautions, protective equipment and emergency procedures Avoid breathing vapours, mist or gas. Ensure adequate ventilation. Evacuate personnel to safe areas. For personal protection see section 8. Environmental precautions Prevent further leakage or spillage if safe to do so. Do not let product enter drains. Methods and materials for containment and cleaning up Contain spillage, and then collect with an electrically protected vacuum cleaner or by wet-brushing and place in container for disposal according to local regulations (see section 13). Reference to other sections For disposal see section 13. SECTION 7: Handling and storage Precautions for safe handling Keep away from sources of ignition - No smoking. For precautions see section 2.2. Conditions for safe storage, including any incompatibilities Store in cool place. Keep container tightly closed in a dry and well-ventilated place. Containers which are opened must be carefully resealed and kept upright to prevent leakage. Recommended storage temperature -20 °C Air and moisture sensitive. Storage class (TRGS 510): Pyrophoric and self-heating hazardous materials Specific end use(s) Apart from the uses mentioned in section 1.2 no other specific uses are stipulated SECTION 8: Exposure controls/personal protection Control parameters Components with workplace control parameters Exposure controls Appropriate engineering controls Handle in accordance with good industrial hygiene and safety practice. Wash hands before breaks and at the end of workday. Personal protective equipment Eye/face protection Face shield and safety glasses Use equipment for eye protection tested and approved under appropriate government standards such as NIOSH (US) or EN 166(EU). Skin protection Handle with gloves. Gloves must be inspected prior to use. Use proper glove removal technique (without touching glove's outer surface) to avoid skin contact with this product. Dispose of contaminated gloves after use in accordance with applicable laws and good laboratory practices. Wash and dry hands. The selected protective gloves have to satisfy the specifications of EU Directive 89/686/EEC and the standard EN 374 derived from it. Body Protection impervious clothing, The type of protective equipment must be selected according to the concentration and amount of the dangerous substance at the specific workplace. Respiratory protection Where risk assessment shows air-purifying respirators are appropriate use a full-face respirator with multi-purpose combination (US) or type ABEK (EN 14387) respirator cartridges as a backup to engineering controls. If the respirator is the sole means of protection, use a full-face supplied air respirator. Use respirators and components tested and approved under appropriate government standards such as NIOSH (US) or CEN (EU). Control of environmental exposure Prevent further leakage or spillage if safe to do so. Do not let product enter drains. SECTION 9: Physical and chemical properties Information on basic physical and chemical properties a) AppearanceForm: liquid Colour: light yellow b) OdourNo data available c) Odour ThresholdNo data available d) pHNo data available e) Melting point/freezingNo data available point f) Initial boiling point and No data available boiling range g) Flash pointNo data available h) Evaporation rateNo data available i) Flammability (solid, gas) No data available j) Upper/lowerNo data available flammability or explosive limits k) Vapour pressureNo data available l) Vapour densityNo data available m) Relative densityNo data available n) Water solubilityNo data available o) Partition coefficient: n- No data available octanol/water p) Auto-ignitionSelf-heating in large quantities; may catch fire. temperature q) DecompositionNo data available temperature r) ViscosityNo data available s) Explosive propertiesNo data available t) Oxidizing propertiesNo data available Other safety information No data available SECTION 10: Stability and reactivity Reactivity No data available Chemical stability Stable under recommended storage conditions. Possibility of hazardous reactions No data available Conditions to avoid No data available Incompatible materials Strong oxidizing agents Hazardous decomposition products Other decomposition products - No data available In the event of fire: see section 5 SECTION 11: Toxicological information Information on toxicological effects Acute toxicity No data available Skin corrosion/irritation No data available Serious eye damage/eye irritation No data available Respiratory or skin sensitisation No data available Germ cell mutagenicity No data available Carcinogenicity IARC:No component of this product present at levels greater than or equal to 0.1% is identified as probable, possible or confirmed human carcinogen by IARC. Reproductive toxicity No data available Specific target organ toxicity - single exposure No data available Specific target organ toxicity - repeated exposure No data available Aspiration hazard No data available Additional Information RTECS: Not available To the best of our knowledge, the chemical, physical, and toxicological properties have not been thoroughly investigated. SECTION 12: Ecological information Toxicity No data available Persistence and degradability No data available Bioaccumulative potential No data available Mobility in soil No data available Results of PBT and vPvB assessment This substance/mixture contains no components considered to be either persistent, bioaccumulative and toxic (PBT), or very persistent and very bioaccumulative (vPvB) at levels of 0.1% or higher. Other adverse effects No data available SECTION 13: Disposal considerations Waste treatment methods Product Burn in a chemical incinerator equipped with an afterburner and scrubber but exert extra care in igniting as this material is highly flammable. Offer surplus and non-recyclable solutions to a licensed disposal company. Contaminated packaging Dispose of as unused product. SECTION 14: Transport information UN number ADR/RID: 3183IMDG: 3183IATA: 3183 UN proper shipping name ADR/RID: SELF-HEATING LIQUID, ORGANIC, N.O.S. (Methyl (5Z,8Z,11Z,14Z)-icosa-5,8,11,14- tetraenoate) IMDG: SELF-HEATING LIQUID, ORGANIC, N.O.S. (Methyl (5Z,8Z,11Z,14Z)-icosa-5,8,11,14- tetraenoate) IATA:Self-heating liquid, organic, n.o.s. (Methyl (5Z,8Z,11Z,14Z)-icosa-5,8,11,14-tetraenoate) Transport hazard class(es) ADR/RID: 4.2IMDG: 4.2IATA: 4.2 Packaging group ADR/RID: IIIIMDG: IIIIATA: III Environmental hazards ADR/RID: noIMDG Marine pollutant: noIATA: no Special precautions for user No data available SECTION 15: Regulatory information This safety datasheet complies with the requirements of Regulation (EC) No. 1907/2006. Safety, health and environmental regulations/legislation specific for the substance or mixture No data available Chemical Safety Assessment For this product a chemical safety assessment was not carried out SECTION 16: Other information Full text of H-Statements referred to under sections 2 and 3. Further information Copyright 2014 Co. LLC. License granted to make unlimited paper copies for internal use only. The above information is believed to be correct but does not purport to be all inclusive and shall be used only as a guide. The information in this document is based on the present state of our knowledge and is applicable to the product with regard to appropriate safety precautions. It does not represent any guarantee of the properties of the product. Corporation and its Affiliates shall not be held liable for any damage resulting from handling or from contact with the above product. See and/or the reverse side of invoice or packing slip for additional terms and conditions of sale.

毒性和生态

生态学数据: 该物质对环境可能有危害，对水体应给予特别注意。

安全

• 符号: GHS07, GHS08, GHS09
• 信号词: Danger
• 危害声明: H304-H315-H336-H410
• 警示性声明: P261-P273-P301 + P310-P331-P501
• 个人防护装备: Eyeshields;Faceshields;Gloves;half-mask respirator (US);multi-purpose combination respirator cartridge (US)
• 危害码 (欧洲): F,Xn,N
• 风险声明 (欧洲): R19
• 安全声明 (欧洲): 9-16-29-33-60-61-62
• 危险品运输编码: UN 3183 4
• WGK德国: 3
• 包装等级: I
• 危险类别: 4.2
• 海关编码: 2916190090

海关

海关编码	2916190090
中文概述	2916190090 其他不饱和无环一元羧酸（包括其酸酐、酰卤化物，过氧化物和过氧酸以及它们的衍生物）。监管条件:AB(入境货物通关单,出境货物通关单)。增值税率:17.0%。退税率:9.0%。最惠国关税:6.5%。普通关税:30.0%
申报要素	品名, 成分含量, 用途, 丙烯酸、丙烯酸盐或酯应报明包装
监管条件	A.入境货物通关单 B.出境货物通关单
检验检疫	R.进口食品卫生监督检验 S.出口食品卫生监督检验 M.进口商品检验 N.出口商品检验
Summary	2916190090 unsaturated acyclic monocarboxylic acids, their anhydrides, halides, peroxides, peroxyacids and their derivatives。supervision conditions:AB(certificate of inspection for goods inward,certificate of inspection for goods outward)。VAT:17.0%。tax rebate rate:9.0%。MFN tariff:6.5%。general tariff:30.0%