14293-44-8

• 常用中文名：希伯胺
• 常用英文名：Xipamide
• CAS号：14293-44-8
• 分子式：C₁₅H₁₅ClN₂O₄S
• 分子量：354.809
• 相关类别： 研究领域 心血管疾病
• 发布时间：2018-04-03 08:00:00
• 更新时间：2024-01-02 17:21:24
• Xipamide 是一种磺胺类利尿剂。Xipamide 是一种能选择性抑制阴离子交换剂 (AE) 的降压药。

名称

• 中文名: 利多速尿
• 英文名: 4-chloro-N-(2,6-dimethylphenyl)-2-hydroxy-5-sulfamoylbenzamide
• 中文别名: 5-(氨基磺酰基)-4-氯-N-(2,6-二甲基苯基)-2-羟基苯甲酰胺; 希伯胺
• 英文别名: Benzamide, 5-(aminosulfonyl)-4-chloro-N-(2,6-dimethylphenyl)-2-hydroxy-; Xipamide; EINECS 238-216-4; Aquaphor; 4-Chloro-2',6'-dimethyl-5-sulfamoylsalicylanilide; 4-Chloro-5-sulfamylsalicyloyl-2',6'-dimethylanilide; Xipamid; 5-(Aminosulfonyl)-4-chloro-N-(2,6-dimethylphenyl)-2-hydroxy-benzamide; 4-Chloro-N-(2,6-dimethylphenyl)-2-hydroxy-5-sulfamoylbenzamide; Zipix; Aquaphoril; 4-chloro-2',6-dimethyl-5-sulfamoylsalicylanilide; Diurexan; 5-(aminosulfonyl)-4-chloro-N-(2,6-dimethylphenyl)-2-hydroxybenzamide

物化性质

• 密度: 1.5±0.1 g/cm3
• 熔点: 255-256ºC
• 分子式: C₁₅H₁₅ClN₂O₄S
• 分子量: 354.809
• 精确质量: 354.044098
• PSA: 117.87000
• LogP: 2.50
• 折射率: 1.653
• 储存条件: Refrigerator
• 计算化学:

  1.疏水参数计算参考值（XlogP）:2.9

  2.氢键供体数量:3

  3.氢键受体数量:5

  4.可旋转化学键数量:3

  5.互变异构体数量:7

  6.拓扑分子极性表面积:118

  7.重原子数量:23

  8.表面电荷:0

  9.复杂度:526

  10.同位素原子数量:0

  11.确定原子立构中心数量:0

  12.不确定原子立构中心数量:0

  13.确定化学键立构中心数量:0

  14.不确定化学键立构中心数量:0

  15.共价键单元数量:1

生物活性

• 描述: Xipamide 是一种磺胺类利尿剂。Xipamide 是一种能选择性抑制阴离子交换剂 (AE) 的降压药。
• 相关类别:
  研究领域 >> 心血管疾病
  信号通路 >> 其他 >> 其他
• 参考文献:

  [1]. Prichard BN, et al. Xipamide. A review of its pharmacodynamic and pharmacokinetic properties and therapeutic efficacy. Drugs. 1985 Oct;30(4):313-32.

  [2]. Hannaert P, et al. Beneficial effects of xipamide on pH and Ca2+ ions of cardiac cells. Arch Mal Coeur Vaiss. 1990 Jul;83(8):1271-4.

毒性和生态

CHEMICAL IDENTIFICATION RTECS NUMBER : VO6920000 CHEMICAL NAME : 2',6'-Salicyloxylidide, 4-chloro-5-sulfamoyl- CAS REGISTRY NUMBER : 14293-44-8 LAST UPDATED : 199612 DATA ITEMS CITED : 7 MOLECULAR FORMULA : C15-H15-Cl-N2-O4-S MOLECULAR WEIGHT : 354.83 HEALTH HAZARD DATA ACUTE TOXICITY DATA TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 1640 mg/kg TOXIC EFFECTS : Behavioral - ataxia Behavioral - coma Lungs, Thorax, or Respiration - respiratory depression REFERENCE : ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 25,245,1975 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 320 mg/kg TOXIC EFFECTS : Behavioral - ataxia Behavioral - coma Lungs, Thorax, or Respiration - respiratory depression REFERENCE : ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 25,245,1975 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 1810 mg/kg TOXIC EFFECTS : Behavioral - ataxia Behavioral - coma Lungs, Thorax, or Respiration - respiratory depression REFERENCE : ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 25,245,1975 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 520 mg/kg TOXIC EFFECTS : Behavioral - ataxia Behavioral - coma Lungs, Thorax, or Respiration - respiratory depression REFERENCE : ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 25,245,1975 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Subcutaneous SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 1480 mg/kg TOXIC EFFECTS : Behavioral - ataxia Behavioral - coma Lungs, Thorax, or Respiration - respiratory depression REFERENCE : ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 25,245,1975 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Mammal - dog DOSE/DURATION : >1500 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 25,245,1975 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Mammal - dog DOSE/DURATION : >50 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 25,245,1975

安全

• 符号: GHS07
• 信号词: Warning
• 危害声明: H315-H319-H335
• 警示性声明: P261-P305 + P351 + P338
• 危害码 (欧洲): Xi
• 风险声明 (欧洲): 36/37/38
• 安全声明 (欧洲): 26
• 危险品运输编码: NONH for all modes of transport
• 海关编码: 2935009090

海关

海关编码	2935009090
中文概述	2935009090 其他磺（酰）胺. 增值税率:17.0% 退税率:9.0% 监管条件:无 最惠国关税:6.5% 普通关税:35.0%
申报要素	品名, 成分含量, 用途
Summary	2935009090 other sulphonamides VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:35.0%