中文名 | 阿维菌素 |
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英文名 | avermectin B1a |
中文别名 |
阿维菌素B1a
阿巴汀 |
英文别名 |
5-O-Demethyl Antibiotic C 076A1a
Abamectinum [Latin] Abamectin B1a AVERMECTIN B1A (1'R,2S,4'S,5S,6R,8'R,10'E,12'S,13'S,14'E,16'E,20'R,21'R,24'S)-6-[(2S)-Butan-2-yl]-21',24'-dihydroxy-5,11',13',22'-tetramethyl-2'-oxo-5,6-dihydrospiro[pyran-2,6'-[3,7,19]trioxatetracyclo[15.6.1.1.0]pentacosa[10,14,16,22]tetraen]-12'-yl 2,6-dideoxy-4-O-(2,6-dideoxy-3-O-methyl-α-L-arabino-hexopyranosyl)-3-O-methyl-α-L-arabino-hexopyranoside Abamectine [French] [3H]-Abamectin B1a (1'R,2S,4'S,5S,6R,8'R,10'E,12'S,13'S,14'E,16'E,20'R,21'R,24'S)-6-[(2S)-2-Butanyl]-21',24'-dihydroxy-12'-{[(2R,4S,5S,6S)-5-{[(2S,4S,5S,6S)-5-hydroxy-4-methoxy-6-methyltetrahydro-2H-pyran-2-yl]oxy}-4-methoxy-6-methyltetrahydro-2H-pyran-2-yl]oxy}-5,11',13',22'-tetramethyl-5,6-dihydro-2'H-spiro[pyran-2,6'-[3,7,19]trioxatetracyclo[15.6.1.1.0]pentacosa[10,14,16,22]tetraen]-2'-one (1'R,2S,4'S,5S,6R,8'R,10'E,12'S,13'S,14'E,16'E,20'R,21'R,24'S)-6-[(2S)-2-Butanyl]-21',24'-dihydroxy-5,11',13',22'-tetramethyl-2'-oxo-5,6-dihydrospiro[pyran-2,6'-[3,7,19]trioxatetracyclo[15.6.1.1.0]pentacosa[10,14,16,22]tetraen]-12'-yl 2,6-dideoxy-4-O-(2,6-dideoxy-3-O-methyl-α-L-arabino-hexopyranosyl)-3-O-methyl-α-L-arabino-hexopyranoside Abamectin komponente B1a 22,23-dihydroavermectinh B1a abamectin component B1a Avermectin B(1)a Abamectina [Spanish] (2aE,4E,5'S,6S,6'R,7S,8E,11R,13S,15S,17aR,20R,20aR,20bS)-6'-[(2S)-butan-2-yl]-20,20b-dihydroxy-5',6,8,19-tetramethyl-17-oxo-5',6,6',10,11,14,15,17,17a,20,20a,20b-dodecahydro-2H,7H-spiro[11,15-methanofuro[4,3,2-pq][2,6]benzodioxacyclooctadecine-13,2'-pyran]-7-yl 2,6-dideoxy-4-O-(2,6-dideoxy-3-O-methyl-α-L-arabino-hexopyranosyl)-3-O-methyl-α-L-arabino-hexopyranoside (2aE,4E,8E)-(5'S,6S,6'R,7S,11R,13S,15S,17aR,20R,20aR,20bS)-6'-((S)-sec-Butyl)-5',6,6',7,10,11,14,15,17a,20,20a,20b-dodecahydro-20,20b-dihydroxy-5',6,8,19-tetramethyl-17-oxospiro(11,15-methano-2H,13H,17H-furo(4,3,2-pq)(2,6)benzodioxacyclooctadecin-13,2'-(2H)pyran)-7-yl 2,6-dideoxy-4-O-(2,6-dideoxy-3-O-methyl-α-L-arabino-hexopyranosyl)-3-O-methyl-α-L-arabino-hexopyranoside Vertimec(R)018SC Caswell No. 063AB (1'R,2S,4'S,5S,6R,8'R,10'E,12'S,13'S,14'E,16'E,20'R,21'R,24'S)-6-[(2S)-2-Butanyl]-21',24'-dihydroxy-5,11',13',22'-tetramethyl-2'-oxo-5,6-dihydrospiro[pyran-2,6'-[3,7,19]trioxatetracyclo[15.6.1.1. 0]pentacosa[10,14,16,22]tetraen]-12'-yl 2,6-dideoxy-4-O-(2,6-dideoxy-3-O-methyl-α-L-arabino-hexopyranosyl)-3-O-methyl-α-L-arabino-hexopyranoside (1'R,2S,4'S,5S,6R,8'R,10'E,12'S,13'S,14'E,16'E,20'R,21'R,24'S)-6-[(2S)-2-Butanyl]-21',24'-dihydroxy-5,11',13',22'-tetramethyl-2'-oxo-5,6-dihydrospiro[pyran-2,6'-[3,7,19]trioxatetracyclo[15.6.1.1.0]pentacosa[10,14,16,22]tetraen]-12'-yl-2,6-dideoxy-4-O-(2,6-dideoxy-3-O-methyl-α-L-arabino-hexopyranosyl)-3-O-methyl-α-L-arabino-hexopyranoside Antibiotic C 076B1a |
描述 | Avermectin B1a 是一种抗寄生虫剂,能够使线虫瘫痪。 |
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相关类别 | |
体外研究 | [3H] AVM B1a优先与来自大鼠脑的几个区域的突触膜结合。 [3H] AVM B1a与完整单层颗粒细胞的特异性结合随孵育时间迅速增加,并在24℃下约20分钟后达到平衡。较高浓度的[3H] AVM B1a导致显着更大的非特异性结合,在25nM时为60%。各种AVM类似物还在完整小脑神经元中产生[3H] AVM B1a结合的浓度依赖性抑制。 AVM B1a和莫昔克丁的效力相似(IC50值分别为120和126 nM)[3]。来自小鼠脑突触小泡的AVMB1a刺激的氯化物流出来自GABA不敏感的氯通道的激活,并且这种作用不同于它们先前记录的对小鼠脑制剂中GABA门控氯通道的影响[4]。 |
体内研究 | 当AVM B1a浓度高于83.3 mg/kg时,细菌受到显着抑制,而真菌在土壤中受损较少。高浓度AVM B1a也抑制了土壤呼吸,这与土壤类型不同。 AVM B1a对土壤蚯蚓的半致死剂量(LD50)在滤纸接触试验中估计为4.63 mg×cm2,在人工土壤中处理7天和14天后分别为24.13和17.06 mg/kg [1]。在人工土壤中,AVM B1a对蚯蚓的LC50分别为24.1 mg/kg和17.1 mg/kg,持续7天和14天。在暴露于无AVM B1a土壤后1天内,两组中分别消除了约80.0%和94.8%的AVM B1a,但在蚯蚓相对较长时间内发现了痕量的AVM B1a [2]。 。 |
参考文献 |
密度 | 1.2±0.1 g/cm3 |
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沸点 | 940.9±65.0 °C at 760 mmHg |
熔点 | 157-162ºC |
分子式 | C48H72O14 |
分子量 | 873.077 |
闪点 | 268.1±27.8 °C |
精确质量 | 872.492188 |
PSA | 170.06000 |
LogP | 6.51 |
外观性状 | 白色结晶粉末 |
蒸汽压 | 0.0±0.6 mmHg at 25°C |
折射率 | 1.571 |
储存条件 | 通风低温干燥 |
计算化学 | 1.疏水参数计算参考值(XlogP):3.8 2.氢键供体数量:3 3.氢键受体数量:14 4.可旋转化学键数量:8 5.互变异构体数量:无 6.拓扑分子极性表面积:170 7.重原子数量:62 8.表面电荷:0 9.复杂度:1730 10.同位素原子数量:0 11.确定原子立构中心数量:20 12.不确定原子立构中心数量:0 13.确定化学键立构中心数量:3 14.不确定化学键立构中心数量:0 15.共价键单元数量:1 |
CHEMICAL IDENTIFICATION
HEALTH HAZARD DATAACUTE TOXICITY DATA
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危险品运输编码 | UN 2588 |
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包装等级 | II |
危险类别 | 6.1(a) |
海关编码 | 2932999099 |
上游产品 9 | |
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下游产品 2 | |
海关编码 | 2932999099 |
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中文概述 | 2932999099. 其他仅含氧杂原子的杂环化合物. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:20.0% |
申报要素 | 品名, 成分含量, 用途 |
Summary | 2932999099. other heterocyclic compounds with oxygen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0% |