1910-42-5

• 常用中文名：甲基紫精
• 常用英文名：Paraquat
• CAS号：1910-42-5
• 分子式：C₁₂H₁₄Cl₂N₂
• 分子量：257.159
• 相关类别： 化学农药原药 除草剂 其他除草剂
• 发布时间：2018-02-06 08:00:00
• 更新时间：2024-01-02 16:04:08
• 二氯百草枯是一种口服活性、快速作用、非选择性接触性除草剂,通过木质部的一些易位被叶子吸收。百草枯二氯化物的吸附弱依赖于PH值[1][2][3][4]。

名称

• 中文名: 百草枯二氯化物
• 英文名: paraquat dichloride
• 中文别名: 1,1-二甲基-4,4'-联吡啶鎓盐二氯化物; 百草枯二氯盐; 百草枯,1,1-二甲基-4,4'-联吡啶鎓盐二氯化物; 甲基紫精; 二氯百草枯; 百草枯; 1,1'-二甲基-4,4'-联吡啶鎓盐二氯化物水合物; 百草枯(PARAQUAT); 吸附树脂D312; 甲基紫精水合物
• 英文别名: 1,1'-dimethyl-4,4'-bipyridilium dichloride; Bipyridinium, 1,1'-dimethyl-4,4'-, dichloride; methylviologen dichloride; 1,1'-Dimethyl-4,4'-bipyridynium dichloride; 1,1′-dimethyl-4,4′ bipyridinium dichloride; 1,1'-dimethyl-4,4'-dipyridinium dichoride; 1,1'-Dimethyl-4,4'-bipyridinium Dichloride Hydrate; Paraquat, dichloride; Paraquat dichloride; MFCD00011986; 1,1'-Dimethyl-4,4'-bipyridinium Dichloride Hydrate; PP910; Paraquat Hydrate; N,N'-Dimethyl-4,4'-dipyridylium dichloride; EFOXON; ok622; Methyl viologen dichloride hydrate; 4,4'-Bipyridinium, 1,1'-dimethyl-, dichloride; EINECS 217-615-7; esgram; Paraquat chloride; 1,1’-dimethyl-4,4’-bipyridinium chloride (1:2); OSAQUAT; 1,1’-dimethyl-[4,4’-bipyridine]-1,1’-diium dichloride; TOTAL; WEEDOL; ah501; 1,1’-dimethyl-4,4’-bipyridinium dichloride; PP 148; 4,4'-Bipyridinium, 1,1'-dimethyl-, chloride (1:2); Methyl viologen dichloride; Purity of Paraquat; 1,1'-Dimethyl-4,4'-bipyridinium dichloride; pathclear; Methyl Viologen Hydrate; PARACOL

物化性质

• 密度: 1.25
• 沸点: 175ºC
• 熔点: >300 °C(lit.)
• 分子式: C₁₂H₁₄Cl₂N₂
• 分子量: 257.159
• 精确质量: 256.053406
• PSA: 7.76000
• 外观性状: 灰白色粉末
• 储存条件:

  密封、在 0-6 ºC下保存

• 稳定性:

  如果遵照规格使用和储存则不会分解，未有已知危险反应，避免氧化物

• 水溶解性: soluble
• 计算化学:

  1、 疏水参数计算参考值（XlogP）：

  2、 氢键供体数量：0

  3、 氢键受体数量：2

  4、 可旋转化学键数量：1

  5、 互变异构体数量：

  6、 拓扑分子极性表面积（TPSA）：7.8

  7、 重原子数量：16

  8、 表面电荷：0

  9、 复杂度：145

  10、同位素原子数量： 0

  11、确定原子立构中心数量：0

  12、不确定原子立构中心数量：0

  13、确定化学键立构中心数量：0

  14、不确定化学键立构中心数量：0

  15、共价键单元数量：3

• 更多:

  1. 性状：粉末

  2. 密度（g/mL,20ºC）：1.25

  3. 相对蒸汽密度（g/mL,空气=1）：未确定

  4. 熔点（ºC）：>300

  5. 沸点（ºC）：未确定

  6. 沸点（ºC，20mmHg）：未确定

  7. 折射率：未确定

  8. 闪点（°F）：未确定

  9. 比旋光度（ºF）：未确定

  10. 自燃点或引燃温度（ºC）：未确定

  11. 蒸气压（kPa,25ºC）：未确定

  12. 饱和蒸气压（kPa,40ºC）：未确定

  13. 燃烧热（KJ/mol）：未确定

  14. 临界温度（ºC）：未确定

  15. 临界压力（KPa）：未确定

  16. 油水（辛醇/水）分配系数的对数值：未确定

  17. 爆炸上限（%,V/V）：未确定

  18. 爆炸下限（%,V/V）：未确定

  19. 溶解性：易溶于水的

生物活性

• 描述: 二氯百草枯是一种口服活性、快速作用、非选择性接触性除草剂,通过木质部的一些易位被叶子吸收。百草枯二氯化物的吸附弱依赖于PH值[1][2][3][4]。
• 相关类别:
  研究领域 >> 其他
  信号通路 >> 其他 >> 其他
• 体外研究: 二氯百草枯在各种动物中的 LD50[2]每组体重的动物数量(g)LD50(mg/kg)雌性大鼠6 130-160口服112(104-122)雌性大白鼠10 150-205口服150(139-162)雌性鼠6 130160口服141(140-142)雌性小鼠6 130-1600腹膜内19(16-21)雌性大大鼠6 1301-160腹膜内16(14-19)雌性豚鼠3 400-500腹膜内3雄性豚鼠5 190-250口服30(22-41)罗德岛岛鸡5 1950-3000口服262(200-346)母猫3 2500-4400口服35(27-46)
• 参考文献:

  [1]. Hamadi NK, et al. Adsorption of Paraquat dichloride from aqueous solution by activated carbon derived from used tires. J Hazard Mater. 2004 Aug 9;112(1-2):133-41.

  [2]. Clark D G, et al. The toxicity of paraquat[J]. Occupational and Environmental Medicine, 1966, 23(2): 126-132.

  [3]. Ladipo M K, et al. Acute Toxicity, Behavioural Changes and Histopathological Effect of Paraquat Dichloride on Tissues of Catfish (Clarias Gariepinus)[J]. International Journal of Biology, 2011.

  [4]. Lock E A, et al. Paraquat[M]//Hayes' Handbook of Pesticide Toxicology. Academic Press, 2010: 1771-1827.

MSDS

第一部分：化学品名称 化学品中文名称: 百草枯 化学品英文名称: Paraquat CAS No.: 1910-42-5 分子式: C12H14Cl2N2 分子量: 257.16 第二部分：成分/组成信息 化学品名称：百草枯 有害物成分: 百草枯 含量: 100 CAS No.: 1910-42-5 第三部分：危险性概述 危险性类别: 第6．1类 毒害品 侵入途径: 吸入 食入 经皮吸收 健康危害: 属中等毒类物质。中毒多为误服所引起，引起口腔、咽部的炎性损伤，同时，引起食管炎、胃炎，对肝、肾有损害作用。中毒数日后，出现呼吸困难及紫绀，呼吸衰竭，往往导致死亡。长期接触可引起指甲损伤、鼻出血和皮炎。 燃爆危险: 本品可燃，有毒。 危险特性: 5.10 与氧化剂会发生反应，遇明火、高热易引起燃烧。 危险性概述: A198 有毒、可燃 安全措施: B04 远离热源、火种，贮于阴凉通风处 第四部分：急救措施 皮肤接触: 立即脱去污染的衣着，用肥皂水及流动清水彻底冲洗污染的皮肤、头发、指甲等。就医。 眼睛接触: 立即提起眼睑，用流动清水冲洗10分钟或用2％碳酸氢钠溶液冲洗。 吸入: 迅速脱离现场至空气新鲜处。呼吸困难时给输氧。呼吸停止时，立即进行人工呼吸。就医。 食入: 误服者给饮大量温水，催吐，可用温水或1：5000高锰酸钾液彻底洗胃。或用2％碳酸氢钠反复洗胃。就医。 第五部分：消防措施 危险特性: 遇明火、高热可燃。与强氧化剂可发生反应。受热分解放出有毒的氧化氮烟气。 有害燃烧产物: 一氧化碳、二氧化碳、氧化氮、氯化氢 灭火方法及灭火剂: 雾状水、泡沫、二氧化碳、砂土。 消防员的个体防护: 消防人员须佩戴防毒面具、穿全身消防服 闪点(℃): 无资料 自燃温度(℃): 无资料 爆炸下限[%(V/V)]: 无资料 爆炸上限[%(V/V)]: 无资料 第六部分：泄漏应急处理 应急处理: 隔离泄漏污染区，周围设警告标志，建议应急处理人员戴好防毒面具，穿化学防护服。不要直接接触泄漏物，避免扬尘，小心扫起，置于袋中转移至安全场所。也可以用大量水冲洗，经稀释的洗水放入废水系统。如大量泄漏，收集回收或无害处理后废弃。 第七部分：操作处置与储存 操作注意事项: 密闭操作，提供充分的局部排风。操作尽可能机械化、自动化。操作人员必须经过专门培训，严格遵守操作规程。建议操作人员佩戴自吸过滤式防尘口罩，戴化学安全防护眼镜，穿防毒物渗透工作服，戴乳胶手套。远离火种、热源，工作场所严禁吸烟。使用防爆型的通风系统和设备。避免产生粉尘。避免与氧化剂、酸类、碱类接触。搬运时要轻装轻卸，防止包装及容器损坏。配备相应品种和数量的消防器材及泄漏应急处理设备。倒空的容器可能残留有害物。 储存注意事项: 储存于阴凉、通风的库房。远离火种、热源。应与氧化剂、酸类、碱类、食用化学品分开存放，切忌混储。配备相应品种和数量的消防器材。储区应备有合适的材料收容泄漏物。 第八部分：接触控制/个体防护 最高容许浓度: 中国MAC：未制定标准苏联MAC：未制定标准美国TWA：OSHA 0．5mg／m3[皮] A 工程控制: 严加密闭，提供充分的局部排风。尽可能机械化、自动化。 呼吸系统防护: 生产操作或农业使用时，建议佩带防毒口罩。紧急事态抢救或逃生时，应该佩带自给式呼吸器。 眼睛防护: 戴化学安全防护眼镜。 身体防护: 穿相应的防护服。 手防护: 戴防护手套。 其他防护: 工作现场禁止吸烟、进食和饮水。工作后，彻底清洗。工作服不要带到非作业场所，单独存放被毒物污染的衣服， 第九部分：理化特性 外观与性状: 白色粉末。 熔点(℃): >300 沸点(℃): 无资料 相对密度(水=1): 无资料 相对蒸气密度(空气=1): 无资料 饱和蒸气压(kPa): 无资料 辛醇/水分配系数的对数值: 无资料 闪点(℃): 无资料 引燃温度(℃): 无资料 爆炸上限%(V/V): 无资料 爆炸下限%(V/V): 无资料 分子式: C12H14Cl2N2 分子量: 257.16 溶解性: 易溶于水，溶于醇、丙酮。 主要用途: 用作除草剂。 第十部分：稳定性和反应活性 稳定性: 在常温常压下 稳定 禁配物: 强氧化剂、强酸、强碱。 聚合危害: 不能出现 分解产物: 一氧化碳、二氧化碳、氧化氮、氯化氢。 第十一部分：毒理学资料 急性毒性: 属中等毒类 LD50：139～162mg／kg(大鼠经口)；325mg／kg(兔经皮) LC50： 第十三部分：废弃处置 废弃处置方法: 处置前应参阅国家和地方有关法规。建议用焚烧法处置。与燃料混合后，再焚烧。焚烧炉排出的气体要通过洗涤器除去。 第十四部分：运输信息 危险货物编号: 61896 UN编号: 2781 包装类别: Ⅱ 包装方法: 塑料袋或二层牛皮纸袋外全开口或中开口钢桶；两层塑料袋或一层塑料袋外麻袋、塑料编织袋、乳胶布袋；塑料袋外复合塑料编织袋（聚丙烯三合一袋、聚乙烯三合一袋、聚丙烯二合一袋、聚乙烯二合一袋）；塑料袋或二层牛皮纸袋外普通木箱；螺纹口玻璃瓶、塑料瓶、复合塑料瓶或铝瓶外普通木箱；塑料瓶、两层塑料袋或两层牛皮纸袋（内或外套以塑料袋）外瓦楞纸箱。 运输注意事项: 储存于阴凉、通风仓间内。远离火种、热源。防止阳光直射。保持容器密封。应与氧化剂、碱类、食用化工原料分开存放。不可混储混运。搬运时要轻装轻卸，防止包装及容器损坏。分装和搬运作业要注意个人防护。 第十五部分：法规信息 国内化学品安全管理法规: 化学危险物品安全管理条例 (1987年2月17日国务院发布)，化学危险物品安全管理条例实施细则 (化劳发[1992] 677号)，工作场所安全使用化学品规定 ([1996]劳部发423号)等法规，针对化学危险品的安全使用、生产、储存、运输、装卸等方面均作了相应规定；常用危险化学品的分类及标志 (GB 13690-92)将该物质划为第6.1 类毒害品。 第十六部分：其他信息 参考文献: 1.周国泰，化学危险品安全技术全书，化学工业出版社，1997 2.国家环保局有毒化学品管理办公室、北京化工研究院合编，化学品毒性法规环境数据手册，中国环境科学出版社.1992 3.Canadian Centre for Occupational Health and Safety,CHEMINFO Database.1998 4.Canadian Centre for Occupational Health and Safety, RTECS Database, 1989 填表时间: 年月日 其他信息: 2 MSDS修改日期: 年月日

毒性和生态

生态学数据: 对水是稍微有危害的不要让未稀释或大量的产品接触地下水、水道或者污水系统，若无政府许可，勿将材料排入周围环境。 CHEMICAL IDENTIFICATION RTECS NUMBER : DW2275000 CHEMICAL NAME : 4,4'-Bipyridinium, 1,1'-dimethyl-, dichloride CAS REGISTRY NUMBER : 1910-42-5 LAST UPDATED : 199806 DATA ITEMS CITED : 105 MOLECULAR FORMULA : C12-H14-N2.2Cl MOLECULAR WEIGHT : 257.18 WISWESSER LINE NOTATION : T6KJ A1 D- DT6KJ A1 &G 2 HEALTH HAZARD DATA ACUTE TOXICITY DATA TYPE OF TEST : Standard Draize test ROUTE OF EXPOSURE : Administration into the eye SPECIES OBSERVED : Rodent - rabbit TYPE OF TEST : Standard Draize test ROUTE OF EXPOSURE : Administration into the eye SPECIES OBSERVED : Rodent - rabbit TYPE OF TEST : LDLo - Lowest published lethal dose ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Human - man DOSE/DURATION : 1720 mg/kg TOXIC EFFECTS : Lungs, Thorax, or Respiration - acute pulmonary edema Liver - liver function tests impaired Kidney, Ureter, Bladder - changes in tubules (including acute renal failure, acute tubular necrosis) TYPE OF TEST : LDLo - Lowest published lethal dose ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Human - man DOSE/DURATION : 3380 uL/kg TOXIC EFFECTS : Lungs, Thorax, or Respiration - fibrosis, focal (pneumoconiosis) Lungs, Thorax, or Respiration - dyspnea Lungs, Thorax, or Respiration - sputum TYPE OF TEST : LDLo - Lowest published lethal dose ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Human DOSE/DURATION : 214 mg/kg TOXIC EFFECTS : Lungs, Thorax, or Respiration - chronic pulmonary edema Lungs, Thorax, or Respiration - other changes TYPE OF TEST : LDLo - Lowest published lethal dose ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Human - woman DOSE/DURATION : 3 gm/kg TOXIC EFFECTS : Behavioral - headache Lungs, Thorax, or Respiration - cough Gastrointestinal - nausea or vomiting TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Human - man DOSE/DURATION : 32 mg/kg TOXIC EFFECTS : Lungs, Thorax, or Respiration - other changes Gastrointestinal - other changes TYPE OF TEST : LDLo - Lowest published lethal dose ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Human - man DOSE/DURATION : 43 mg/kg TOXIC EFFECTS : Liver - other changes Kidney, Ureter, Bladder - changes in both tubules and glomeruli Kidney, Ureter, Bladder - urine volume decreased TYPE OF TEST : LDLo - Lowest published lethal dose ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Human - woman DOSE/DURATION : 111 mg/kg TOXIC EFFECTS : Lungs, Thorax, or Respiration - dyspnea Gastrointestinal - ulceration or bleeding from stomach Kidney, Ureter, Bladder - changes in tubules (including acute renal failure, acute tubular necrosis) TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 57 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Administration onto the skin SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 80 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 26 mg/kg TOXIC EFFECTS : Brain and Coverings - recordings from specific areas of CNS Behavioral - changes in motor activity (specific assay) Lungs, Thorax, or Respiration - respiratory stimulation TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Subcutaneous SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 27 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 21 mg/kg TOXIC EFFECTS : Lungs, Thorax, or Respiration - acute pulmonary edema Gastrointestinal - hypermotility, diarrhea Skin and Appendages - hair TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 120 mg/kg TOXIC EFFECTS : Lungs, Thorax, or Respiration - fibrosis (interstitial) Biochemical - Metabolism (Intermediary) - lipids including transport TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 20 mg/kg TOXIC EFFECTS : Lungs, Thorax, or Respiration - acute pulmonary edema Lungs, Thorax, or Respiration - other changes TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Subcutaneous SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 37 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 180 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Mammal - dog DOSE/DURATION : 25 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value TYPE OF TEST : LDLo - Lowest published lethal dose ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Mammal - dog DOSE/DURATION : 34500 ug/kg TOXIC EFFECTS : Gastrointestinal - hypermotility, diarrhea Gastrointestinal - nausea or vomiting Lungs, Thorax, or Respiration - dyspnea TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Primate - monkey DOSE/DURATION : 50 mg/kg TOXIC EFFECTS : Behavioral - convulsions or effect on seizure threshold Lungs, Thorax, or Respiration - emphysema Kidney, Ureter, Bladder - changes in tubules (including acute renal failure, acute tubular necrosis) TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Mammal - cat DOSE/DURATION : 35 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Administration onto the skin SPECIES OBSERVED : Rodent - rabbit DOSE/DURATION : 325 mg/kg TOXIC EFFECTS : Skin and Appendages - cutaneous sensitization, experimental (after topical exposure) TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - rabbit DOSE/DURATION : 18 mg/kg TOXIC EFFECTS : Behavioral - excitement Behavioral - changes in motor activity (specific assay) Lungs, Thorax, or Respiration - dyspnea TYPE OF TEST : LDLo - Lowest published lethal dose ROUTE OF EXPOSURE : Ocular SPECIES OBSERVED : Rodent - rabbit DOSE/DURATION : 100 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Mammal - pig DOSE/DURATION : 30 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - guinea pig DOSE/DURATION : 22 mg/kg TOXIC EFFECTS : Behavioral - somnolence (general depressed activity) Lungs, Thorax, or Respiration - other changes TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - guinea pig DOSE/DURATION : 3 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Bird - chicken DOSE/DURATION : 362 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Bird - duck DOSE/DURATION : 199 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Administration onto the skin SPECIES OBSERVED : Bird - duck DOSE/DURATION : 600 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Parenteral SPECIES OBSERVED : Amphibian - frog DOSE/DURATION : 260 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value TYPE OF TEST : LDLo - Lowest published lethal dose ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Bird - turkey DOSE/DURATION : 250 mg/kg TOXIC EFFECTS : Gastrointestinal - hypermotility, diarrhea TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Administration onto the skin SPECIES OBSERVED : Bird - turkey DOSE/DURATION : 375 mg/kg TOXIC EFFECTS : Gastrointestinal - hypermotility, diarrhea TYPE OF TEST : LDLo - Lowest published lethal dose ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Bird - turkey DOSE/DURATION : 20 mg/kg TOXIC EFFECTS : Gastrointestinal - hypermotility, diarrhea TYPE OF TEST : LDLo - Lowest published lethal dose ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Bird - turkey DOSE/DURATION : 12500 ug/kg TOXIC EFFECTS : Gastrointestinal - hypermotility, diarrhea TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Mammal - domestic DOSE/DURATION : 30 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Mammal - domestic DOSE/DURATION : 1 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 608 mg/kg/19W-I TOXIC EFFECTS : Liver - other changes Endocrine - hypoglycemia Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - transaminases TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 1638 mg/kg/13W-C TOXIC EFFECTS : Cardiac - changes in heart weight Liver - changes in liver weight Nutritional and Gross Metabolic - weight loss or decreased weight gain TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 187 mg/kg/30D-C TOXIC EFFECTS : Blood - pigmented or nucleated red blood cells Blood - changes in leukocyte (WBC) count Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - transaminases TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 232 mg/kg/15D-C TOXIC EFFECTS : Lungs, Thorax, or Respiration - changes in lung weight Nutritional and Gross Metabolic - weight loss or decreased weight gain Biochemical - Metabolism (Intermediary) - other proteins TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 13140 mg/kg/2Y-C TOXIC EFFECTS : Lungs, Thorax, or Respiration - other changes Blood - changes in leukocyte (WBC) count Nutritional and Gross Metabolic - weight loss or decreased weight gain TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 3276 mg/kg/13W-C TOXIC EFFECTS : Lungs, Thorax, or Respiration - changes in lung weight Nutritional and Gross Metabolic - weight loss or decreased weight gain Related to Chronic Data - death TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - rabbit DOSE/DURATION : 64 mg/kg/14D-I TOXIC EFFECTS : Kidney, Ureter, Bladder - other changes Biochemical - Metabolism (Intermediary) - lipids including transport Related to Chronic Data - death TYPE OF TEST : TCLo - Lowest published toxic concentration ROUTE OF EXPOSURE : Inhalation SPECIES OBSERVED : Rodent - guinea pig DOSE/DURATION : 400 ug/m3/6H/3W-I TOXIC EFFECTS : Lungs, Thorax, or Respiration - respiratory depression TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Oral DOSE : 149 mg/kg SEX/DURATION : female 7-17 day(s) after conception TOXIC EFFECTS : Reproductive - Maternal Effects - other effects TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Oral DOSE : 14 mg/kg SEX/DURATION : female 1-3 day(s) after conception TOXIC EFFECTS : Reproductive - Maternal Effects - parturition Reproductive - Fertility - pre-implantation mortality (e.g. reduction in number of implants per female; total number of implants per corpora lutea) Reproductive - Fertility - other measures of fertility TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Oral DOSE : 300 mg/kg SEX/DURATION : female 1-3 day(s) after conception TOXIC EFFECTS : Reproductive - Fertility - post-implantation mortality (e.g. dead and/or resorbed implants per total number of implants) Reproductive - Effects on Newborn - live birth index (measured after birth) TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Oral DOSE : 14 mg/kg SEX/DURATION : female 1-3 day(s) after conception TOXIC EFFECTS : Reproductive - Effects on Newborn - stillbirth TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Intraperitoneal DOSE : 6500 ug/kg SEX/DURATION : female 6 day(s) after conception TOXIC EFFECTS : Reproductive - Specific Developmental Abnormalities - musculoskeletal system TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Subcutaneous DOSE : 7 mg/kg SEX/DURATION : female 21 day(s) after conception TOXIC EFFECTS : Reproductive - Specific Developmental Abnormalities - cardiovascular (circulatory) system TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Oral DOSE : 1163 gm/kg SEX/DURATION : multigeneration TOXIC EFFECTS : Reproductive - Fertility - female fertility index (e.g. # females pregnant per # sperm positive females; # females pregnant per # females mated) TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Oral DOSE : 1785 gm/kg SEX/DURATION : multigeneration TOXIC EFFECTS : Reproductive - Effects on Newborn - other postnatal measures or effects TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Intraperitoneal DOSE : 30150 ug/kg SEX/DURATION : female 8-16 day(s) after conception TOXIC EFFECTS : Reproductive - Fertility - post-implantation mortality (e.g. dead and/or resorbed implants per total number of implants) TYPE OF TEST : Specific locus test TYPE OF TEST : Sex chromosome loss and nondisjunction TYPE OF TEST : Mutation test systems - not otherwise specified TYPE OF TEST : DNA inhibition MUTATION DATA TYPE OF TEST : Mutation test systems - not otherwise specified TEST SYSTEM : Bird - chicken Liver DOSE/DURATION : 50 mg/L REFERENCE : EJTXAZ European Journal of Toxicology and Environmental Hygiene. (Paris, France) V.7-9, 1974-76. For publisher information, see TOERD9. Volume(issue)/page/year: 8,226,1975 *** REVIEWS *** TOXICOLOGY REVIEW FEPRA7 Federation Proceedings, Federation of American Societies for Experimental Biology. (Bethesda, MD) V.1-46, 1942-87. Volume(issue)/page/year: 35,89,1976 TOXICOLOGY REVIEW CNDQA8 Cahiers de Nutrition et de Dietetique. (Editions Meteore, 42, rue du Louvre, 75001 Paris, France) V.1- 1966- Volume(issue)/page/year: 10(3),43,1975 TOXICOLOGY REVIEW CRTXB2 CRC Critical Reviews in Toxicology. (CRC Press, Inc., 2000 Corporate Blvd., NW, Boca Raton, FL 33431) V.1- 1971- Volume(issue)/page/year: 1(1),93,1971 TOXICOLOGY REVIEW DTTIAF Deutsche Tieraerztliche Wochenschrift. (Hanover, Fed. Rep. Ger.) V.1-77, 1893-1970. Volume(issue)/page/year: 80,485,1973 TOXICOLOGY REVIEW FNSCA6 Forensic Science. (Lausanne, Switzerland) V.1-11, 1972-78. For pub lisher information, see FSINDR. Volume(issue)/page/year: 2,67,1973 TOXICOLOGY REVIEW EVHPAZ EHP, Environmental Health Perspectives. (U.S. Government Printing Office, Supt of Documents, Washington, DC 20402) No.1- 1972- Volume(issue)/page/year: 15,121,1976 TOXICOLOGY REVIEW AJHPA9 American Journal of Hospital Pharmacy. (American Soc. of Hospital Pharmacists, 4630 Montgomery Ave., Bethesda, MD 20814) V.15- 1958- Volume(issue)/page/year: 35,1368,1978 TOXICOLOGY REVIEW CTOXAO Clinical Toxicology. (New York, NY) V.1-18, 1968-81. For publisher information, see JTCTDW. Volume(issue)/page/year: 14,1,1979 *** U.S. STANDARDS AND REGULATIONS *** EPA FIFRA 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATION FEREAC Federal Register. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) V.1- 1936- Volume(issue)/page/year: 54,7740,1989 OSHA PEL (Gen Indu):8H TWA 0.5 mg/m3 (skin), respirable dust CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) Volume(issue)/page/year: 29,1910.1000,1994 OSHA PEL (Construc):8H TWA 0.5 mg/m3 (skin), respirable dust CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) Volume(issue)/page/year: 29,1926.55,1994 OSHA PEL (Shipyard):8H TWA 0.5 mg/m3 (skin), respirable dust CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) Volume(issue)/page/year: 29,1915.1000,1993 *** OCCUPATIONAL EXPOSURE LIMITS *** OEL-DENMARK:TWA 0.1 mg/m3;Skin JAN 1993 OEL-GERMANY:TWA 0.1 mg/m3;Skin JAN 1993 OEL-SWITZERLAND:TWA 0.1 mg/m3;STEL 0.2 mg/m3;Skin JAN 1993 OEL-UNITED KINGDOM:TWA 0.1 mg/m3 JAN 1993 OEL IN BULGARIA, COLOMBIA, JORDAN, KOREA check ACGIH TLV OEL IN NEW ZEALAND, SINGAPORE, VIETNAM check ACGIH TLV *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - 84723 No. of Facilities: 699 (estimated) No. of Industries: 2 No. of Occupations: 3 No. of Employees: 873 (estimated)

安全

• 危害码 (欧洲): T+: Very toxic;N: Dangerous for the environment;
• 风险声明 (欧洲): R24/25;R26;R36/37/38;R48/25;R50/53
• 安全声明 (欧洲): S22-S28-S36/37/39-S45-S60-S61-S28A
• 危险品运输编码: UN 2811 6.1/PG 1
• WGK德国: 3
• RTECS号: DW2275000
• 包装等级: II
• 危险类别: 6.1(a)
• 海关编码: 2933399022

上下游产品

上游产品  8
1983-60-4 553-26-4 74-88-4 77-78-1
74-87-3 1910-42-5 98-95-3 26985-31-9
下游产品  10
1910-42-5 98-95-3 124-13-0 464-72-2
26985-31-9 67-64-1 553-26-4 15591-62-5
645-49-8 100-52-7

海关

海关编码	2933399090
中文概述	2933399090. 其他结构含非稠合吡啶环的化合物. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:20.0%
申报要素	品名, 成分含量, 用途, 乌洛托品请注明外观, 6－己内酰胺请注明外观, 签约日期
Summary	2933399090. other compounds containing an unfused pyridine ring (whether or not hydrogenated) in the structure. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%