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134-63-4生产厂家

134-63-4价格

相关CAS号：
134-63-4 34552-83-5
26786-32-3 98079-52-8
21498-08-8 405165-61-9
7179-49-9 215447-89-5
215447-90-8 57-37-4
2320572-00-5 1158522-08-7
940364-43-2 134104-43-1
131615-57-1 6906-52-1
930439-75-1 1018584-77-4
1375289-11-4 849349-65-1

134-63-4

134-63-4结构式
134-63-4结构式

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中文名 盐酸山梗碱
英文名 α-Lobeline Hydrochcloride
中文别名 盐酸洛贝林
2-[1-甲基-6-(beta-羟基苯乙基)-2-哌啶基]苯乙酮盐酸盐
山梗烷醇酮盐酸盐
盐酸-L-山梗碱
英文别名 Ethanone, 2-[(2R,6S)-6-[(2S)-2-hydroxy-2-phenylethyl]-1-methyl-2-piperidinyl]-1-phenyl-, hydrochloride (1:1)
2-[6-(2-Hydroxy-2-phenylethyl)-1-methyl-2-piperidinyl]-1-phenylethanone hydrochloride (1:1)
Lobelin hydrochloride
Lobeline hydrochloride
EINECS 205-150-2
2-{(2R,6S)-6-[(2S)-2-Hydroxy-2-phenylethyl]-1-methyl-2-piperidinyl}-1-phenylethanone hydrochloride
2-{(2R,6S)-6-[(2S)-2-Hydroxy-2-phenylethyl]-1-methyl-2-piperidinyl}-1-phenylethanone hydrochloride (1:1)
MFCD00082455
Ethanone, 2-((2R,6S)-6-((2S)-2-hydroxy-2-phenylethyl)-1-methyl-2-piperidinyl)-1-phenyl-, hydrochloride
Ethanone, 2-[6-(2-hydroxy-2-phenylethyl)-1-methyl-2-piperidinyl]-1-phenyl-, hydrochloride (1:1)
2-{(2R,6S)-6-[(2S)-2-Hydroxy-2-phenylethyl]-1-methylpiperidin-2-yl}-1-phenylethanone hydrochloride (1:1)
2-{(2R,6S)-6-[(2S)-2-Hydroxy-2-phenylethyl]-1-methyl-2-piperidinyl}-1-phenylethanonhydrochlorid
α-Lobeline hydrochloride
(-)-Lobeline hydrochloride
2-{(2R,6S)-6-[(2S)-2-Hydroxy-2-phényléthyl]-1-méthyl-2-pipéridinyl}-1-phényléthanone chlorhydrate
2-(6-(2-Hydroxy-2-phenylethyl)-1-methylpiperidin-2-yl)-1-phenylethanone hydrochloride
Lobeline (hydrochloride)
描述 Lobeline盐酸盐是烟碱样受体激动剂, 作为有效的神经元烟碱受体α3β2和α4β2拮抗剂。
相关类别
沸点 485.6ºC at 760mmHg
熔点 183-185 °C (dec.)(lit.)
分子式 C22H28ClNO2
分子量 373.916
闪点 247.5ºC
精确质量 373.180847
PSA 40.54000
LogP 4.97590
外观性状 白色至灰白色固体
蒸汽压 3.02E-11mmHg at 25°C
折射率 -57.5 ° (C=1, H2O)
储存条件

保持贮藏器密封、储存在阴凉、干燥的地方，确保工作间有良好的通风或排气装置

稳定性

如果遵照规格使用和储存则不会分解，未有已知危险反应

水溶解性 H2O: 25 mg/mL
分子结构

1、摩尔折射率：无可用的

2、摩尔体积（cm3/mol）：无可用的

3、等张比容（90.2K）：无可用的

4、表面张力（dyne/cm）：无可用的

5、介电常数：无可用的

6、极化率（10-24cm3）：无可用的

7、单一同位素质量：373.180857 Da

8、标称质量：373 Da

9、平均质量：373.9162 Da
计算化学

1、 疏水参数计算参考值（XlogP）：

2、 氢键供体数量：2

3、 氢键受体数量：3

4、 可旋转化学键数量：6

5、 互变异构体数量：2

6、 拓扑分子极性表面积（TPSA）：40.5

7、 重原子数量：26

8、 表面电荷：0

9、 复杂度：412

10、 同位素原子数量：0

11、 确定原子立构中心数量：3

12、 不确定原子立构中心数量：0

13、 确定化学键立构中心数量：0

14、 不确定化学键立构中心数量：0

15、 共价键单元数量：2

更多

1. 性状：白色或黄白色粉末

2. 密度（g/mL,25℃）：未确定

3. 相对蒸汽密度（g/mL,空气=1）：未确定

4. 熔点（ºC）：183-185

5. 沸点（ºC,常压）：未确定

6. 沸点（ºC,0.4KPa）：未确定

7. 折射率（C=1，H2O）：-57.5 º

8. 闪点（ºC）：未确定

9. 比旋光度（º）：未确定

10. 自燃点或引燃温度（ºC）：未确定

11. 蒸气压（mmHg,25ºC）：未确定

12. 饱和蒸气压（kPa,20ºC）：未确定

13. 燃烧热（KJ/mol）：未确定

14. 临界温度（ºC）：未确定

15. 临界压力（KPa）：未确定

16. 油水（辛醇/水）分配系数的对数值：未确定

17. 爆炸上限（%,V/V）：未确定

18. 爆炸下限（%,V/V）：未确定

19. 溶解性：水：0.25mg/ml

Section I.Chemical Product and Company Identification
Chemical Name Lobeline Hydrochloride
Portland OR
SynonymNot available.
C22H27NO2•HCl
Chemical Formula
134-63-4
CAS Number
Section II.Composition and Information on Ingredients
Toxicology Data
Chemical NameCAS Number Percent (%)TLV/PEL
Lobeline Hydrochloride134-63-4Min. 98.0 Not available.Mouse LD50 (intraperitoneal) 39900
(HPLC,T)ug/kg
Mouse LD50 (intravenous) 7800
ug/kg
Mouse LD50 (subcutaneous) 87500
ug/kg
Section III. Hazards Identification
Acute Health EffectsToxic if ingested or inhaled. Avoid prolonged contact with this material. Overexposure may result in serious illness or death.
Follow safe industrial hygiene practices and always wear proper protective equipment when handling this compound.
Chronic Health EffectsCARCINOGENIC EFFECTS : Not available.
MUTAGENIC EFFECTS : Not available.
TERATOGENIC EFFECTS : Not available.
DEVELOPMENTAL TOXICITY: Not available.
Repeated exposure to an highly toxic material may produce general deterioration of health by an accumulation in one or
many human organs.
Section IV.First Aid Measures
Eye ContactCheck for and remove any contact lenses. In case of contact, immediately flush eyes with plenty of water for at least 15
minutes. Get medical attention.
Skin ContactIn case of contact, immediately flush skin with plenty of water for at least 15 minutes while removing contaminated clothing
and shoes. Wash clothing before reuse. Thoroughly clean shoes before reuse. Get medical attention immediately.
If the victim is not breathing, perform mouth-to-mouth resuscitation. Loosen tight clothing such as a collar, tie, belt or
Inhalation
waistband. If breathing is difficult, oxygen can be administered. Seek medical attention if respiration problems do not
improve.
INDUCE VOMITING by sticking finger in throat. Lower the head so that the vomit will not reenter the mouth and throat.
Ingestion
Loosen tight clothing such as a collar, tie, belt or waistband. If the victim is not breathing, perform mouth-to-mouth
resuscitation. Examine the lips and mouth to ascertain whether the tissues are damaged, a possible indication that the toxic
material was ingested; the absence of such signs, however, is not conclusive.
Section V.Fire and Explosion Data
Not available.
May be combustible at high temperature.Auto-Ignition
Flammability
Flash PointsFlammable LimitsNot available.
Not available.
These products are toxic carbon oxides (CO, CO2), nitrogen oxides (NO, NO2), halogenated compounds.
Combustion Products
WARNING: Highly toxic HCl gas is produced during combustion.
Fire Hazards
Not available.
Explosion HazardsRisks of explosion of the product in presence of mechanical impact: Not available.
Risks of explosion of the product in presence of static discharge: Not available.
Fire Fighting Media
SMALL FIRE: Use DRY chemical powder.
LARGE FIRE: Use water spray, fog or foam. DO NOT use water jet.
and Instructions
Consult with local fire authorities before attempting large scale fire-fighting operations.
Continued on Next Page
Lobeline Hydrochloride
Section VI.Accidental Release Measures
Spill CleanupToxic material.
Stop leak if without risk. DO NOT get water inside container. DO NOT touch spilled material. Use water spray to reduce
Instructions
vapors. Prevent entry into sewers, basements or confined areas; dike if needed. Eliminate all sources of ignition. Consult
federal, state, and/or local authorities for assistance on disposal.
Section VII. Handling and Storage
TOXIC. Keep locked up.. Keep away from heat. Mechanical exhaust required. When not in use, tightly seal the container
Handling and Storage
and store in a dry, cool place. Avoid excessive heat and light. DO NOT ingest. Do not breathe dust. Wear suitable
Information
protective clothing. If ingested, seek medical advice immediately and show the container or the label. Treat symptomatically
and supportively.
Section VIII. Exposure Controls/Personal Protection
Use process enclosures, local exhaust ventilation, or other engineering controls to keep airborne levels below recommended
Engineering Controls
exposure limits. If user operations generate dust, fume or mist, use ventilation to keep exposure to airborne contaminants
below the exposure limit.
Splash goggles. Lab coat. Dust respirator. Boots. Gloves. A MSHA/NIOSH approved respirator must be used to avoid
Personal Protection
inhalation of the product. Suggested protective clothing might not be sufficient; consult a specialist BEFORE handling this
product.
Exposure LimitsNot available.
Section IX. Physical and Chemical Properties
Solid. (White powder.)Solubility
Physical state @ 20°CSoluble in water, alcohol.
Very soluble in chloroform.
Not available.Very slightly soluble in ether.
Specific Gravity
373.92
Molecular WeightPartition CoefficientNot available.
Boiling PointNot available.Vapor PressureNot applicable.
180°C (356°F)Not available.
Melting PointVapor Density
Not available.VolatilityNot available.
Refractive Index
Not available.
Critical TemperatureNot available.Odor
ViscosityNot available.TasteNot available.
Section X.Stability and Reactivity Data
Stability
This material is stable if stored under proper conditions. (See Section VII for instructions)
Conditions of InstabilityAvoid excessive heat and light.
Incompatibilities
Reactive with strong oxidizing agents.
Section XI. Toxicological Information
OJ8490100
RTECS Number
Routes of ExposureEye Contact. Ingestion. Inhalation.
Mouse LD50 (intraperitoneal) 39900 ug/kg
Toxicity Data
Mouse LD50 (intravenous) 7800 ug/kg
Mouse LD50 (subcutaneous) 87500 ug/kg
Chronic Toxic EffectsCARCINOGENIC EFFECTS : Not available.
MUTAGENIC EFFECTS : Not available.
TERATOGENIC EFFECTS : Not available.
DEVELOPMENTAL TOXICITY: Not available.
Repeated exposure to an highly toxic material may produce general deterioration of health by an accumulation in one or many
human organs.
Acute Toxic EffectsToxic if ingested or inhaled. Avoid prolonged contact with this material. Overexposure may result in serious illness or death.
Follow safe industrial hygiene practices and always wear proper protective equipment when handling this compound.
Continued on Next Page
Lobeline Hydrochloride
Section XII.Ecological Information
EcotoxicityNot available.
Not available.
Environmental Fate
Section XIII. Disposal Considerations
Recycle to process, if possible. Consult your local regional authorities. You may be able to dissolve or mix material with a
Waste Disposal
combustible solvent and burn in a chemical incinerator equipped with an afterburner and scrubber system. Observe all
federal, state and local regulations when disposing of the substance.
Section XIV. Transport Information
DOT ClassificationDOT CLASS 6.1: Toxic material.
PIN Number
Proper Shipping NameAlkaloids, solid, n.o.s.
III
Packing Group (PG)
DOT Pictograms
Section XV. Other Regulatory Information and Pictograms
TSCA Chemical InventoryThis product is NOT on the EPA Toxic Substances Control Act (TSCA) inventory. The following notices are required by 40
CFR 720.36 (C) for those products not on the inventory list:
(EPA)
(i) These products are supplied solely for use in research and development by or under the supervision of a technically
qualified individual as defined in 40 CFR 720.0 et sec.
(ii) The health risks of these products have not been fully determined. Any information that is or becomes available will be
supplied on an MSDS sheet.
WHMIS ClassificationCLASS D-1B: Material causing immediate and serious toxic effects (TOXIC).
(Canada)
EINECS Number (EEC) 205-150-2
EEC Risk StatementsR23/24/25- Toxic by inhalation, in contact with skin and if swallowed.

SECTION 16 - ADDITIONAL INFORMATION
N/A

毒理学数据:

1、 急性毒性：小鼠腹腔LD50：39900μg/kg

小鼠皮下LD50：87500μg/kg

小鼠静脉注射LD50：7800μg/kg

青蛙肠外LDLo：150mg/kg

生态学数据:

根据国家和地方有关法规的要求处置。或与厂商或制造商联系，确定处置方法。

CHEMICAL IDENTIFICATION

RTECS NUMBER :
OJ8490100
CHEMICAL NAME :
Lobeline, hydrochloride
CAS REGISTRY NUMBER :
134-63-4
LAST UPDATED :
198706
DATA ITEMS CITED :
4
MOLECULAR FORMULA :
C22-H27-N-O2.Cl-H
MOLECULAR WEIGHT :
373.96
WISWESSER LINE NOTATION :
T6NTJ A1 B1YQR& F1VR &GH

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
39900 ug/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: 6,913,1982
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Subcutaneous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
87500 ug/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: 6,913,1982
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
7800 ug/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: 6,913,1982
TYPE OF TEST :
LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE :
Parenteral
SPECIES OBSERVED :
Amphibian - frog
DOSE/DURATION :
150 mg/kg
TOXIC EFFECTS :
Peripheral Nerve and Sensation - spastic paralysis with or without sensory change Behavioral - convulsions or effect on seizure threshold
REFERENCE :
AEPPAE Naunyn-Schmiedeberg's Archiv fuer Experimentelle Pathologie und Pharmakologie. (Berlin, Ger.) V.110-253, 1925-66. For publisher information, see NSAPCC. Volume(issue)/page/year: 163,279,1931

符号 GHS06
GHS06
信号词 Danger
危害声明 H301 + H331
警示性声明 P261-P301 + P310-P311
个人防护装备 Eyeshields;Faceshields;Gloves;type P2 (EN 143) respirator cartridges
危害码 (欧洲) T:Toxic;
风险声明 (欧洲) R23/25
安全声明 (欧洲) S36/37/39-S45
危险品运输编码 UN 1544 6.1/PG 3
WGK德国 3
RTECS号 OJ8490100
包装等级 III
危险类别 6.1(b)

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