27912-14-7

• 常用中文名：盐酸左布诺洛尔
• 常用英文名：Levobunolol hydrochloride
• CAS号：27912-14-7
• 分子式：C₁₇H₂₆ClNO₃
• 分子量：327.84600
• 相关类别： 原料药 循环系统用药 抗心律失常药
• 发布时间：2018-02-12 08:00:00
• 更新时间：2024-01-13 13:02:25
• Levobunolol盐酸盐是一种非选择性的β-阻断剂, 局部用药治疗青光眼。

名称

• 中文名: 盐酸左布诺洛尔
• 英文名: levobunolol hydrochloride
• 中文别名: 消旋-5-[3-叔丁氨基-2-羟丙氧基]3,4-双氢-1-(2H)萘酮盐酸盐; 5-[3-叔丁基氨基-2-羟基丙氧基]-3,4-二氢-2H-萘-1-酮盐酸盐
• 英文别名: gotensin; l-bunololhydrochloride; vistagan; Levobunolol hydrochloride; AG-901; w7000a; betagan; LEVOBUNOLOL HCL

物化性质

• 沸点: 464.4ºC at 760mmHg
• 熔点: 209-211°
• 分子式: C₁₇H₂₆ClNO₃
• 分子量: 327.84600
• 闪点: 234.7ºC
• 精确质量: 327.16000
• PSA: 58.56000
• LogP: 3.52630
• 蒸汽压: 2.01E-09mmHg at 25°C
• 储存条件: 2-8℃

生物活性

• 描述: Levobunolol盐酸盐是一种非选择性的β-阻断剂, 局部用药治疗青光眼。
• 相关类别:
  信号通路 >> 其他 >> 其他
  研究领域 >> 其他

毒性和生态

CHEMICAL IDENTIFICATION RTECS NUMBER : QK4402500 CHEMICAL NAME : 1(2H)-Naphthalenone, 3,4-dihydro-5-(3-(tert-butylamino)-2-hydroxypropoxy)- , hydrochloride, (-)- CAS REGISTRY NUMBER : 27912-14-7 LAST UPDATED : 199309 DATA ITEMS CITED : 8 MOLECULAR FORMULA : C17-H25-N-O3.Cl-H MOLECULAR WEIGHT : 327.89 HEALTH HAZARD DATA ACUTE TOXICITY DATA TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 700 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : GEPHDP General Pharmacology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.6- 1975- Volume(issue)/page/year: 17,373,1986 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 25 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : GEPHDP General Pharmacology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.6- 1975- Volume(issue)/page/year: 17,373,1986 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 1220 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : 43NDAD "Pharmacology of Antihypertensive Drugs," Scriabine, A., ed., New York, Raven Press, 1980 Volume(issue)/page/year: -,317,1980 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 78 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : GEPHDP General Pharmacology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.6- 1975- Volume(issue)/page/year: 17,373,1986 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Mammal - dog DOSE/DURATION : 100 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : GEPHDP General Pharmacology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.6- 1975- Volume(issue)/page/year: 17,373,1986 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - hamster DOSE/DURATION : 435 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : GEPHDP General Pharmacology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.6- 1975- Volume(issue)/page/year: 17,373,1986 ** OTHER MULTIPLE DOSE TOXICITY DATA ** TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 131 gm/kg/2Y-C TOXIC EFFECTS : Kidney, Ureter, Bladder - other changes in urine composition Nutritional and Gross Metabolic - weight loss or decreased weight gain Related to Chronic Data - death REFERENCE : FAATDF Fundamental and Applied Toxicology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1981- Volume(issue)/page/year: 18,353,1992 ** TUMORIGENIC DATA ** TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 112 gm/kg/80W-C TOXIC EFFECTS : Tumorigenic - neoplastic by RTECS criteria Reproductive - Tumorigenic effects - uterine tumors Tumorigenic - tumor types after systemic administration not seen spontaneously REFERENCE : FAATDF Fundamental and Applied Toxicology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1981- Volume(issue)/page/year: 18,353,1992