91-85-0

• 常用中文名：N1-(4-甲氧基苄基)-N2,N2-二甲基-N1-(嘧啶-2-基)乙烷-1,2-二胺
• 常用英文名：Thonzylamine
• CAS号：91-85-0
• 分子式：C₁₆H₂₂N₄O
• 分子量：286.37200
• 相关类别： 原料药 抗变态反应药 抗组胺药
• 发布时间：2018-09-18 18:41:44
• 更新时间：2024-01-14 18:59:45
• Thonzylamine 是一种具有口服活性的 H1 组胺受体拮抗剂,具有良好的抗组胺和抗过敏特性。Thonzylamine 可用于过敏性疾病,鼻充血,过敏性结膜炎和其他过敏性疾病的研究。

名称

• 中文名: 松齐拉敏
• 英文名: N'-[(4-methoxyphenyl)methyl]-N,N-dimethyl-N'-pyrimidin-2-ylethane-1,2-diamine
• 英文别名: thonzylamine; Tonzilamine; Neohetramine

物化性质

• 密度: 1.121g/cm3
• 沸点: 440.6ºC at 760 mmHg
• 分子式: C₁₆H₂₂N₄O
• 分子量: 286.37200
• 闪点: 220.3ºC
• 精确质量: 286.17900
• PSA: 41.49000
• LogP: 2.05340
• 折射率: 1.584
• 储存条件: 2-8°C， 惰性气体

生物活性

• 描述: Thonzylamine 是一种具有口服活性的 H1 组胺受体拮抗剂,具有良好的抗组胺和抗过敏特性。Thonzylamine 可用于过敏性疾病,鼻充血,过敏性结膜炎和其他过敏性疾病的研究。
• 相关类别:
  信号通路 >> 免疫及炎症 >> 组胺受体
  研究领域 >> 炎症/免疫
  信号通路 >> G 蛋白偶联受体/G 蛋白 >> 组胺受体
• 靶点:

  H1 Receptor

• 参考文献:

  [1]. Zhou S, et, al. Design, synthesis and biological activity of a novel ethylenediamine derivatives as H 1 receptor antagonists. Bioorg Med Chem. 2019 Dec 15; 27(24): 115127.

  [2]. AARON TH, et, al. Neohetramine and thephorin; two new antihistaminic drugs. Can Med Assoc J. 1948 Nov; 59(5): 438-41.

毒性和生态

CHEMICAL IDENTIFICATION RTECS NUMBER : UV8575000 CHEMICAL NAME : Pyrimidine, 2-((2-(dimethylamino)ethyl)(p-methoxybenzyl)amino)- CAS REGISTRY NUMBER : 91-85-0 BEILSTEIN REFERENCE NO. : 0284655 LAST UPDATED : 199612 DATA ITEMS CITED : 5 MOLECULAR FORMULA : C16-H22-N4-O MOLECULAR WEIGHT : 286.42 WISWESSER LINE NOTATION : T6N CNJ BN1R DO1&2N1&1 HEALTH HAZARD DATA ACUTE TOXICITY DATA TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Human - woman DOSE/DURATION : 2 mg/kg TOXIC EFFECTS : Behavioral - general anesthetic Behavioral - convulsions or effect on seizure threshold Lungs, Thorax, or Respiration - cyanosis REFERENCE : JOALAS Journal of Allergy. (St. Louis, MO) V.1-47, 1929-71. For publisher information, see JACIBY. Volume(issue)/page/year: 19,313,1948 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 245 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : PSEBAA Proceedings of the Society for Experimental Biology and Medicine. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1903/04- Volume(issue)/page/year: 66,512,1947 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 119 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : PSEBAA Proceedings of the Society for Experimental Biology and Medicine. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1903/04- Volume(issue)/page/year: 66,512,1947 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - guinea pig DOSE/DURATION : 493 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : PSEBAA Proceedings of the Society for Experimental Biology and Medicine. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1903/04- Volume(issue)/page/year: 66,512,1947 ** REPRODUCTIVE DATA ** TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Intramuscular DOSE : 50 mg/kg SEX/DURATION : female 5 day(s) after conception TOXIC EFFECTS : Reproductive - Fertility - pre-implantation mortality (e.g. reduction in number of implants per female; total number of implants per corpora lutea) REFERENCE : PSEBAA Proceedings of the Society for Experimental Biology and Medicine. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1903/04- Volume(issue)/page/year: 100,555,1959

安全

• 海关编码: 2933599090

合成路线

2393-23-9 ~% 91-85-0

文献：Farmaco, Edizione Scientifica, , vol. 39, # 3 p. 189 - 199

6957-21-7 107-99-3 ~% 91-85-0

文献：Takamine Kenkyusho Nenpo, , vol. 4, p. 36,38 Chem.Abstr., , p. 11665 DE823598 , ; DRP/DRBP Org.Chem. US2465865 , ; Yakugaku Zasshi, , vol. 72, p. 1447,1450 Chem.Abstr., , p. 8080

90042-89-0 ~% 91-85-0

文献：Farmaco, Edizione Scientifica, , vol. 39, # 3 p. 189 - 199

1722-12-9 65875-39-0 ~% 91-85-0

文献：Yakugaku Zasshi, , vol. 71, p. 1316 Chem.Abstr., , p. 8123

21244-39-3 ~% 91-85-0

文献：Yakugaku Zasshi, , vol. 72, p. 1447,1450 Chem.Abstr., , p. 8080

91907-70-9 ~% 91-85-0

文献：Yakugaku Zasshi, , vol. 71, p. 1316 Chem.Abstr., , p. 8123

上下游产品

上游产品  6
2393-23-9 6957-21-7 107-99-3 90042-89-0
1722-12-9 65875-39-0
下游产品  2
68303-34-4 726-18-1

海关

海关编码	2933599090
中文概述	2933599090. 其他结构上有嘧啶环的化合物(包括其他结构上有哌嗪环的化合物. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:20.0%
申报要素	品名, 成分含量, 用途, 乌洛托品请注明外观, 6－己内酰胺请注明外观, 签约日期
Summary	2933599090. other compounds containing a pyrimidine ring (whether or not hydrogenated) or piperazine ring in the structure. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%