Shanghai Nianxing Industrial Co., Ltd
China
Product Name: Thonzylamine
Price:
Purity: 99.45%
Stocking Period: 10 Day
Contact: Yang

DC Chemicals Limited
China
Product Name: Thonzylamine
Price: $Inquiry/250mg $Inquiry/100mg $Inquiry/1g
Purity: 98.0%
Stocking Period: 3 Day
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Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: thonzylamine
Price: $Inquiry/100g $Inquiry/1kg $Inquiry/100kg $Inquiry/1000kg
Purity: 98.0%
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91-85-0

91-85-0 structure

Name: Thonzylamine
Chemical Name: N'-[(4-methoxyphenyl)methyl]-N,N-dimethyl-N'-pyrimidin-2-ylethane-1,2-diamine
CAS Number: 91-85-0
Molecular Formula: C₁₆H₂₂N₄O
Molecular Weight: 286.37200
Catalog: API Antiallergic Antihistamine
Create Date: 2018-09-18 18:41:44
Modify Date: 2024-01-14 18:59:45
Thonzylamine is an orally active H1 histamine receptor antagonist, exhibits good antihistaminic and antianaphylactic properties. Thonzylamine can be used for the research of hypersensitivity diseases, nasal congestion, allergic conjunctivitis and other allergic diseases[1][2].

Name	N'-[(4-methoxyphenyl)methyl]-N,N-dimethyl-N'-pyrimidin-2-ylethane-1,2-diamine
Synonyms	thonzylamine Tonzilamine Neohetramine

Description	Thonzylamine is an orally active H1 histamine receptor antagonist, exhibits good antihistaminic and antianaphylactic properties. Thonzylamine can be used for the research of hypersensitivity diseases, nasal congestion, allergic conjunctivitis and other allergic diseases[1][2].
Related Catalog	Signaling Pathways >> Immunology/Inflammation >> Histamine Receptor Research Areas >> Inflammation/Immunology Signaling Pathways >> GPCR/G Protein >> Histamine Receptor
Target	H1 Receptor
References	[1]. Zhou S, et, al. Design, synthesis and biological activity of a novel ethylenediamine derivatives as H 1 receptor antagonists. Bioorg Med Chem. 2019 Dec 15; 27(24): 115127. [2]. AARON TH, et, al. Neohetramine and thephorin; two new antihistaminic drugs. Can Med Assoc J. 1948 Nov; 59(5): 438-41.

Density	1.121g/cm3
Boiling Point	440.6ºC at 760 mmHg
Molecular Formula	C₁₆H₂₂N₄O
Molecular Weight	286.37200
Flash Point	220.3ºC
Exact Mass	286.17900
PSA	41.49000
LogP	2.05340
Index of Refraction	1.584

CHEMICAL IDENTIFICATION

RTECS NUMBER :: UV8575000

CHEMICAL NAME :: Pyrimidine, 2-((2-(dimethylamino)ethyl)(p-methoxybenzyl)amino)-

CAS REGISTRY NUMBER :: 91-85-0

BEILSTEIN REFERENCE NO. :: 0284655

LAST UPDATED :: 199612

DATA ITEMS CITED :: 5

MOLECULAR FORMULA :: C16-H22-N4-O

MOLECULAR WEIGHT :: 286.42

WISWESSER LINE NOTATION :: T6N CNJ BN1R DO1&2N1&1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Human - woman

DOSE/DURATION :: 2 mg/kg

TOXIC EFFECTS :: Behavioral - general anesthetic Behavioral - convulsions or effect on seizure threshold Lungs, Thorax, or Respiration - cyanosis

REFERENCE :: JOALAS Journal of Allergy. (St. Louis, MO) V.1-47, 1929-71. For publisher information, see JACIBY. Volume(issue)/page/year: 19,313,1948

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 245 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: PSEBAA Proceedings of the Society for Experimental Biology and Medicine. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1903/04- Volume(issue)/page/year: 66,512,1947

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 119 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: PSEBAA Proceedings of the Society for Experimental Biology and Medicine. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1903/04- Volume(issue)/page/year: 66,512,1947

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - guinea pig

DOSE/DURATION :: 493 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: PSEBAA Proceedings of the Society for Experimental Biology and Medicine. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1903/04- Volume(issue)/page/year: 66,512,1947 ** REPRODUCTIVE DATA **

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Intramuscular

DOSE :: 50 mg/kg

SEX/DURATION :: female 5 day(s) after conception

TOXIC EFFECTS :: Reproductive - Fertility - pre-implantation mortality (e.g. reduction in number of implants per female; total number of implants per corpora lutea)

REFERENCE :: PSEBAA Proceedings of the Society for Experimental Biology and Medicine. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1903/04- Volume(issue)/page/year: 100,555,1959

HS Code	2933599090

2393-23-9

91-85-0

Literature: Farmaco, Edizione Scientifica, , vol. 39, # 3 p. 189 - 199

6957-21-7

107-99-3

91-85-0

Literature: Takamine Kenkyusho Nenpo, , vol. 4, p. 36,38 Chem.Abstr., , p. 11665 DE823598 , ; DRP/DRBP Org.Chem. US2465865 , ; Yakugaku Zasshi, , vol. 72, p. 1447,1450 Chem.Abstr., , p. 8080

90042-89-0

91-85-0

Literature: Farmaco, Edizione Scientifica, , vol. 39, # 3 p. 189 - 199

1722-12-9

65875-39-0

91-85-0

Literature: Yakugaku Zasshi, , vol. 71, p. 1316 Chem.Abstr., , p. 8123

21244-39-3

91-85-0

Literature: Yakugaku Zasshi, , vol. 72, p. 1447,1450 Chem.Abstr., , p. 8080

91907-70-9

91-85-0

Literature: Yakugaku Zasshi, , vol. 71, p. 1316 Chem.Abstr., , p. 8123

Precursor 6
2393-23-9 6957-21-7 107-99-3 90042-89-0
1722-12-9 65875-39-0
DownStream 2
68303-34-4 726-18-1

HS Code	2933599090
Summary	2933599090. other compounds containing a pyrimidine ring (whether or not hydrogenated) or piperazine ring in the structure. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

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