479-21-0

• 常用中文名：柯托苷； 2,6-二羟基-4-甲氧基二苯甲酮
• 常用英文名：Cotoin
• CAS号：479-21-0
• 分子式：C₁₄H₁₂O₄
• 分子量：244.243
• 相关类别： 天然产物 酚类
• 发布时间：2018-02-13 08:00:00
• 更新时间：2024-01-11 11:59:27
• Cotoin 是从 Garcinia virgate 茎皮中分离出的一种天然产物。

名称

• 中文名: 可托因
• 英文名: (2,6-dihydroxy-4-methoxyphenyl)-phenylmethanone
• 中文别名: 柯托苷
• 英文别名: BENZOPHENONE,2,6-DIHYDROXY-4-METHOXY; Methanone, (2,6-dihydroxy-4-methoxyphenyl)phenyl-; Monomethyl ether of 2,4,6-trihydroxybenzophenone; 2,6-Dihydroxy-4-methoxy-benzophenon; Cotoin; (2,6-Dihydroxy-4-methoxyphenyl)(phenyl)methanone; 2,6-Dihydroxy-4-methoxybenzophenone

物化性质

• 密度: 1.3±0.1 g/cm3
• 沸点: 402.2±45.0 °C at 760 mmHg
• 熔点: 131-132°
• 分子式: C₁₄H₁₂O₄
• 分子量: 244.243
• 闪点: 153.3±22.2 °C
• 精确质量: 244.073563
• PSA: 66.76000
• LogP: 4.07
• 外观性状: 黄色粉末
• 蒸汽压: 0.0±1.0 mmHg at 25°C
• 折射率: 1.624
• 储存条件: 室温

生物活性

• 描述: Cotoin 是从 Garcinia virgate 茎皮中分离出的一种天然产物。
• 相关类别:
  研究领域 >> 其他
  信号通路 >> 其他 >> 其他
• 参考文献:

  [1]. Merza J, et al. Prenylated xanthones and tocotrienols from Garcinia virgata. Phytochemistry. 2004 Nov;65(21):2915-20.

毒性和生态

CHEMICAL IDENTIFICATION RTECS NUMBER : DJ1050000 CHEMICAL NAME : Benzophenone, 2,6-dihydroxy-4-methoxy- CAS REGISTRY NUMBER : 479-21-0 BEILSTEIN REFERENCE NO. : 1981817 LAST UPDATED : 199709 DATA ITEMS CITED : 1 MOLECULAR FORMULA : C14-H12-O4 MOLECULAR WEIGHT : 244.26 WISWESSER LINE NOTATION : 1OR CQ EQ DVR HEALTH HAZARD DATA ACUTE TOXICITY DATA TYPE OF TEST : LDLo - Lowest published lethal dose ROUTE OF EXPOSURE : Subcutaneous SPECIES OBSERVED : Amphibian - frog DOSE/DURATION : 242 mg/kg TOXIC EFFECTS : Behavioral - changes in motor activity (specific assay) Cardiac - change in force of contraction Lungs, Thorax, or Respiration - other changes REFERENCE : BIZEA2 Biochemische Zeitschrift. (Berlin, Ger.) V.1-346, 1906-67. For publisher information, see EJBCAI. Volume(issue)/page/year: 74,340,1916

合成路线

2174-64-3 98-88-4 ~67% 479-21-0

文献：Mitasev, Branko; Porco Jr., John A. Organic Letters, 2009 , vol. 11, # 11 p. 2285 - 2288

98-88-4 ~% 479-21-0

文献：Thevenin, Marion; Mouray, Elisabeth; Grellier, Philippe; Dubois, Joelle European Journal of Organic Chemistry, 2014 , vol. 2014, # 14 p. 2986 - 2992

621-23-8 ~% 479-21-0

文献：Thevenin, Marion; Mouray, Elisabeth; Grellier, Philippe; Dubois, Joelle European Journal of Organic Chemistry, 2014 , vol. 2014, # 14 p. 2986 - 2992

186581-53-3 ~% 479-21-0

文献：Spaeth; Fuchs Monatshefte fuer Chemie, 1921 , vol. 42, p. 272

125557-63-3 ~% 479-21-0

文献：Harris,T.M.; Wachter,M.P. Tetrahedron, 1970 , vol. 26, p. 5255 - 5263

3770-80-7 ~4% 479-21-0 3555-86-0

文献：Thevenin, Marion; Mouray, Elisabeth; Grellier, Philippe; Dubois, Joelle European Journal of Organic Chemistry, 2014 , vol. 2014, # 14 p. 2986 - 2992

2174-64-3 98-88-4 ~% 479-21-0 81525-12-4

文献：Iinuma, Munekazu; Tosa, Hideki; Ito, Tetsuro; Tanaka, Toshiyuki; Riswan, Soedarsono Chemical and Pharmaceutical Bulletin, 1996 , vol. 44, # 9 p. 1744 - 1747

186581-53-3 60-29-7 3555-86-0 ~% 479-21-0 详细

文献：Spaeth; Fuchs Monatshefte fuer Chemie, 1921 , vol. 42, p. 272

上下游产品

上游产品  8
2174-64-3 98-88-4 3770-80-7 621-23-8
186581-53-3 125557-63-3 60-29-7 3555-86-0
下游产品  3
108-73-6 65-85-0 2174-64-3