2304-81-6

• 常用中文名：N-硬脂酰神经鞘氨醇
• 常用英文名：C18 CERAMIDE
• CAS号：2304-81-6
• 分子式：C₃₆H₇₁NO₃
• 分子量：565.95400
• 相关类别： 化学试剂 有机试剂 脂肪醇
• 发布时间：2018-04-09 08:00:00
• 更新时间：2024-01-21 09:25:38
• C18-Ceramide 可以促进受损神经元的谷氨酸胞吐作用。C18-Ceramide 促进神经胶质瘤细胞的细胞死亡。Ceramide (神经酰胺) 参与多种细胞功能,例如分化、细胞周期进程、细胞间粘附、衰老和细胞凋亡。

名称

• 中文名: N-硬脂酰神经鞘氨醇
• 英文名: c18 ceramide
• 中文别名: (2R,3R,4E)-硬脂酰鞘氨醇
• 英文别名: STEAROYL CERAMIDE; ceramide c18; N-((2S,3R,E)-1,3-dihydroxyoctadec-4-en-2-yl)stearamide; N-Stearoyl-D-erythro-sphingosine; N-stearoylsphingosine; Cer(d18:1/18:0); N-STEAROYLSPHINGANINE; C18 DIHYDROCERAMIDE; N-(octadecanoyl)-sphing-4-enine; N-18:0 SPHINGANINE; C18-D-ERYTHRO-CERAMIDE; N-stearoyl-D-erythro-sphingosine; N-Stearoyl-D-sphingosine; 18:0 CERAMIDE; N-((2S,3R,4E)-1,3-dihydroxyoctadec-4-en-2-yl)stearamide; (2S,3R,4E)-2-(N-stearoylamino)-4-octadecene-1,3-diol; N-STEAROYL CERAMIDE

物化性质

• 密度: 0.915g/cm3
• 沸点: 694.5ºC at 760 mmHg
• 熔点: 99 - 101ºC
• 分子式: C₃₆H₇₁NO₃
• 分子量: 565.95400
• 闪点: 373.8ºC
• 精确质量: 565.54300
• PSA: 69.56000
• LogP: 10.73410
• 外观性状: 白色粉末
• 蒸汽压: 2.59E-22mmHg at 25°C
• 折射率: 1.479
• 储存条件:

  冷藏应贮存于阴凉，干燥的地方。存放于密闭容器中。-20°C储存

• 稳定性:

  常温常压下稳定

• 分子结构:

  1、 摩尔折射率：175.5

  2、 摩尔体积（m³/mol）：618.0

  3、 等张比容（90.2K）：1512.8

  4、 表面张力（dyne/cm）：35.8

  5、 极化率（10 ^-24cm ³）：69.57

• 计算化学:

  1.疏水参数计算参考值（XlogP）:13.9

  2.氢键供体数量:3

  3.氢键受体数量:3

  4.可旋转化学键数量:32

  5.互变异构体数量:2

  6.拓扑分子极性表面积69.6

  7.重原子数量:40

  8.表面电荷:0

  9.复杂度:536

  10.同位素原子数量:0

  11.确定原子立构中心数量:2

  12.不确定原子立构中心数量:0

  13.确定化学键立构中心数量:1

  14.不确定化学键立构中心数量:0

  15.共价键单元数量:1

• 更多:

  1. 性状：白色粉末

  2. 密度（g/L,25ºC）：未确定

  3. 相对蒸汽密度（g/mL,空气=1）：未确定

  4. 熔点（ºC）：99-101

  5. 沸点（ºC,常压）：未确定

  6. 沸点（ºC 1.2Kpa）：未确定

  7. 折射率（nD20）：未确定

  8. 闪点（ºC）：未确定

  9. 比旋光度（）：未确定

  10. 自燃点或引燃温度（ºC）：未确定

  11. 蒸气压（Pa,25ºC）：未确定

  12. 饱和蒸气压（kPa,20ºC）：未确定

  13. 燃烧热（KJ/mol）：未确定

  14. 临界温度（ºC）：未确定

  15. 临界压力（KPa）：未确定

  16. 油水（辛醇/水）分配系数的对数值：未确定

  17. 爆炸上限（%,V/V）：未确定

  18. 爆炸下限（%,V/V）：未确定

  19. 溶解性：不溶于水

生物活性

• 描述: C18-Ceramide 可以促进受损神经元的谷氨酸胞吐作用。C18-Ceramide 促进神经胶质瘤细胞的细胞死亡。Ceramide (神经酰胺) 参与多种细胞功能,例如分化、细胞周期进程、细胞间粘附、衰老和细胞凋亡。
• 相关类别:
  研究领域 >> 癌症
  信号通路 >> 其他 >> 其他
  研究领域 >> 神经疾病
• 参考文献:

  [1]. Tang N, et al. Differential effects of ceramide species on exocytosis in rat PC12 cells. Exp Brain Res. 2007 Nov;183(2):241-7.

  [2]. Wang Z, et al. Overexpression of ceramide synthase 1 increases C18-ceramide and leads to lethal autophagy in human glioma. Oncotarget. 2017 Oct 23;8(61):104022-104036.

MSDS

Name: N-Stearoyl-D-erythro-spinghosine synthetical 99+% Material Safety Data Sheet Synonym: Ceramide C1 CAS: 2304-81-6 Section 1 - Chemical Product MSDS Name:N-Stearoyl-D-erythro-spinghosine synthetical 99+% Material Safety Data Sheet Synonym:Ceramide C1 Section 2 - COMPOSITION, INFORMATION ON INGREDIENTS CAS# Chemical Name content EINECS# 2304-81-6 N-Stearoyl-D-erythro-spinghosine, synt 99+% unlisted Hazard Symbols: None Listed. Risk Phrases: None Listed. Section 3 - HAZARDS IDENTIFICATION EMERGENCY OVERVIEW Not available. Potential Health Effects Eye: May cause eye irritation. Skin: May cause skin irritation. Ingestion: May cause irritation of the digestive tract. The toxicological properties of this substance have not been fully investigated. Inhalation: May cause respiratory tract irritation. Chronic: Not available. Section 4 - FIRST AID MEASURES Eyes: Flush eyes with plenty of water for at least 15 minutes, occasionally lifting the upper and lower eyelids. Get medical aid. Skin: Get medical aid. Flush skin with plenty of water for at least 15 minutes while removing contaminated clothing and shoes. Ingestion: Get medical aid. Wash mouth out with water. Inhalation: Remove from exposure and move to fresh air immediately. If not breathing, give artificial respiration. If breathing is difficult, give oxygen. Get medical aid. Notes to Physician: Section 5 - FIRE FIGHTING MEASURES General Information: As in any fire, wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear. Extinguishing Media: Use extinguishing media most appropriate for the surrounding fire. Section 6 - ACCIDENTAL RELEASE MEASURES General Information: Use proper personal protective equipment as indicated in Section 8. Spills/Leaks: Vacuum or sweep up material and place into a suitable disposal container. Section 7 - HANDLING and STORAGE Handling: Avoid breathing dust, vapor, mist, or gas. Avoid contact with skin and eyes. Storage: Store in a tightly closed container. Deep freeze (below -20C). Keep refrigerated. (Store below 4C/39F.) Section 8 - EXPOSURE CONTROLS, PERSONAL PROTECTION Engineering Controls: Use adequate ventilation to keep airborne concentrations low. Exposure Limits CAS# 2304-81-6: Personal Protective Equipment Eyes: Not available. Skin: Wear appropriate protective gloves to prevent skin exposure. Clothing: Wear appropriate protective clothing to prevent skin exposure. Respirators: Follow the OSHA respirator regulations found in 29 CFR 1910.134 or European Standard EN 149. Use a NIOSH/MSHA or European Standard EN 149 approved respirator if exposure limits are exceeded or if irritation or other symptoms are experienced. Section 9 - PHYSICAL AND CHEMICAL PROPERTIES Physical State: Powder Color: white Odor: Not available. pH: Not available. Vapor Pressure: Not available. Viscosity: Not available. Boiling Point: Not available. Freezing/Melting Point: 99 - 101 deg C Autoignition Temperature: Not available. Flash Point: Not available. Explosion Limits, lower: Not available. Explosion Limits, upper: Not available. Decomposition Temperature: Solubility in water: insoluble Specific Gravity/Density: Molecular Formula: Molecular Weight: 565.96 Section 10 - STABILITY AND REACTIVITY Chemical Stability: Not available. Conditions to Avoid: Incompatible materials. Incompatibilities with Other Materials: Strong oxidizing agents. Hazardous Decomposition Products: Carbon monoxide, oxides of nitrogen, carbon dioxide. Hazardous Polymerization: Has not been reported Section 11 - TOXICOLOGICAL INFORMATION RTECS#: CAS# 2304-81-6 unlisted. LD50/LC50: Not available. Carcinogenicity: N-Stearoyl-D-erythro-spinghosine, synthetical - Not listed by ACGIH, IARC, or NTP. Section 12 - ECOLOGICAL INFORMATION Section 13 - DISPOSAL CONSIDERATIONS Dispose of in a manner consistent with federal, state, and local regulations. Section 14 - TRANSPORT INFORMATION IATA Shipping Name: Not regulated. Hazard Class: UN Number: Packing Group: IMO Shipping Name: Not regulated. Hazard Class: UN Number: Packing Group: RID/ADR Shipping Name: Not regulated. Hazard Class: UN Number: Packing group: Section 15 - REGULATORY INFORMATION European/International Regulations European Labeling in Accordance with EC Directives Hazard Symbols: Not available. Risk Phrases: Safety Phrases: S 24/25 Avoid contact with skin and eyes. WGK (Water Danger/Protection) CAS# 2304-81-6: No information available. Canada None of the chemicals in this product are listed on the DSL/NDSL list. CAS# 2304-81-6 is not listed on Canada's Ingredient Disclosure List. US FEDERAL TSCA CAS# 2304-81-6 is not listed on the TSCA inventory. It is for research and development use only. SECTION 16 - ADDITIONAL INFORMATION N/A

毒性和生态

生态学数据: 对水是稍微有害的，不要让未稀释或大量的产品接触地下水，水道或者污水系统，若无政府许可，勿将材料排入周围环境

安全

• 安全声明 (欧洲): S24/25
• 海关编码: 29225000