14008-79-8

• 常用中文名：3-CPMT
• 常用英文名：3-CPMT
• CAS号：14008-79-8
• 分子式：C₂₁H₂₅Cl₂NO
• 分子量：378.34
• 相关类别： 信号通路 神经信号通路 多巴胺转运蛋白
• 发布时间：2016-11-21 02:17:44
• 更新时间：2024-01-20 09:09:24
• 3-CPMT(托品-4-氯苯甲醚盐酸盐)是一种强效的多巴胺摄取抑制剂[1]。3-CPMT(盐酸托品-4-氯苯甲醚)是一种有效的长效抗组胺剂[2]。

名称

• 英文名: 3-[(4-chlorophenyl)-phenylmethoxy]-8-methyl-8-azabicyclo[3.2.1]octane,hydrochloride
• 英文别名: Clobenztropin-hydrochlorid; Chlortropbenzyl; Desipramine hydrochloride; WY 2149; SL-6057; FC-1; 3-CPMT; Tropine 4-chlorobenzhydryl ether hydrochloride

物化性质

• 沸点: 437.2ºC at 760mmHg
• 分子式: C₂₁H₂₅Cl₂NO
• 分子量: 378.34
• 闪点: 218.2ºC
• 精确质量: 377.13100
• PSA: 12.47000
• LogP: 5.81110
• 蒸汽压: 7.62E-08mmHg at 25°C

生物活性

• 描述: 3-CPMT(托品-4-氯苯甲醚盐酸盐)是一种强效的多巴胺摄取抑制剂[1]。3-CPMT(盐酸托品-4-氯苯甲醚)是一种有效的长效抗组胺剂[2]。
• 相关类别:
  信号通路 >> 神经信号通路 >> 多巴胺转运蛋白
  研究领域 >> 神经疾病
• 参考文献:

  [1]. A H Newman, et al. Novel 3 alpha-(diphenylmethoxy)tropane analogs: potent dopamine uptake inhibitors without cocaine-like behavioral profiles. J Med Chem. 1994 Jul 22;37(15):2258-61

  [2]. A H Newman, et al. Novel 3 alpha-(diphenylmethoxy)tropane analogs: potent dopamine uptake inhibitors without cocaine-like behavioral profiles. J Med Chem. 1994 Jul 22;37(15):2258-61

毒性和生态

CHEMICAL IDENTIFICATION RTECS NUMBER : YM3055500 CHEMICAL NAME : 1-alpha-H,5-alpha-H-Tropane, 3-alpha-((p-chloro-alpha-phenylbenzyl)oxy)-, hydrochloride CAS REGISTRY NUMBER : 14008-79-8 LAST UPDATED : 199606 DATA ITEMS CITED : 7 MOLECULAR FORMULA : C21-H24-Cl-N-O.Cl-H MOLECULAR WEIGHT : 378.37 HEALTH HAZARD DATA ACUTE TOXICITY DATA TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 364 mg/kg TOXIC EFFECTS : Behavioral - tremor Behavioral - muscle weakness Behavioral - ataxia REFERENCE : JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year: 114,192,1955 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 58 mg/kg TOXIC EFFECTS : Behavioral - tremor Behavioral - muscle weakness Behavioral - ataxia REFERENCE : JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year: 114,192,1955 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 174 mg/kg TOXIC EFFECTS : Behavioral - tremor Behavioral - muscle weakness Behavioral - ataxia REFERENCE : JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year: 114,192,1955 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 32 mg/kg TOXIC EFFECTS : Behavioral - tremor Behavioral - muscle weakness Behavioral - ataxia REFERENCE : JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year: 114,192,1955 TYPE OF TEST : LDLo - Lowest published lethal dose ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Mammal - dog DOSE/DURATION : 28 mg/kg TOXIC EFFECTS : Vascular - BP lowering not characterized in autonomic section Lungs, Thorax, or Respiration - respiratory stimulation REFERENCE : JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year: 114,192,1955 ** OTHER MULTIPLE DOSE TOXICITY DATA ** TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 3120 mg/kg/26W-I TOXIC EFFECTS : Nutritional and Gross Metabolic - weight loss or decreased weight gain Related to Chronic Data - death REFERENCE : JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year: 114,192,1955 TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Mammal - dog DOSE/DURATION : 1560 mg/kg/26W-I TOXIC EFFECTS : Behavioral - muscle weakness Kidney, Ureter, Bladder - changes in tubules (including acute renal failure, acute tubular necrosis) Related to Chronic Data - death REFERENCE : JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year: 114,192,1955

安全

• 危害码 (欧洲): Xn: Harmful;
• 风险声明 (欧洲): R22
• 安全声明 (欧洲): S26
• WGK德国: 3

合成路线

134-83-8 120-29-6 ~76% 14008-79-8

文献：Newman, Amy Hauck; Allen, Andrew C.; Izenwasser, Sari; Katz, Jonathan L. Journal of Medicinal Chemistry, 1994 , vol. 37, # 15 p. 2258 - 2261

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