3863-59-0

• 常用中文名：氢化可的松磷酸盐
• 常用英文名：Hydrocortisone phosphate
• CAS号：3863-59-0
• 分子式：C₂₁H₃₁O₈P
• 分子量：442.44000
• 相关类别： 信号通路 G 蛋白偶联受体/G 蛋白 糖皮质激素受体
• 发布时间：2017-01-18 13:39:27
• 更新时间：2024-01-13 19:15:30
• Hydrocortisone磷酸盐是Cortisol的医药术语, 是一种类固醇激素, 属于糖皮质激素类激素, 通过糖异生增加血糖, 抑制免疫系统,并协助脂肪, 蛋白质和碳水化合物代谢。

名称

• 中文名: 氢化可的松磷酸盐
• 英文名: cortisol phosphate
• 英文别名: Cortisol 21-monophosphate; hydrocortone; Hydrocortisone phosphate; 21-Hydrocortisonephosphoric acid; Cortisol phosphate; hydrocortisone 21-phosphate; Hydrocortisone dihydrogen phosphate; Cortisol 21-phosphate; hydrocortisone sodium phosphate; Cortisol 21-phosphoric acid; Hydrocortisone 21-(dihydrogen phosphate); Corphos

物化性质

• 密度: 1.42g/cm3
• 沸点: 669.9ºC at 760mmHg
• 分子式: C₂₁H₃₁O₈P
• 分子量: 442.44000
• 闪点: 358.9ºC
• 精确质量: 442.17600
• PSA: 151.17000
• LogP: 1.89860
• 折射率: 1.596
• 储存条件: 2-8℃

生物活性

• 描述: Hydrocortisone磷酸盐是Cortisol的医药术语, 是一种类固醇激素, 属于糖皮质激素类激素, 通过糖异生增加血糖, 抑制免疫系统,并协助脂肪, 蛋白质和碳水化合物代谢。
• 相关类别:
  信号通路 >> G 蛋白偶联受体/G 蛋白 >> 糖皮质激素受体
  研究领域 >> 代谢疾病

毒性和生态

CHEMICAL IDENTIFICATION RTECS NUMBER : GM9005000 CHEMICAL NAME : Cortisol, 21-(dihydrogen phosphate) CAS REGISTRY NUMBER : 3863-59-0 LAST UPDATED : 199504 DATA ITEMS CITED : 6 MOLECULAR FORMULA : C21-H31-O8-P MOLECULAR WEIGHT : 442.49 WISWESSER LINE NOTATION : L E5 B666 OV MUTJ A1 CQ E1 FV1OPQQO FQ HEALTH HAZARD DATA ACUTE TOXICITY DATA TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Subcutaneous DOSE : 6 mg/kg SEX/DURATION : female 24-26 day(s) after conception TOXIC EFFECTS : Reproductive - Effects on Embryo or Fetus - other effects to embryo REFERENCE : PEREBL Pediatric Research. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1967- Volume(issue)/page/year: 11,845,1977 TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Intravenous DOSE : 450 mg/kg SEX/DURATION : female 8-16 day(s) after conception TOXIC EFFECTS : Reproductive - Fertility - post-implantation mortality (e.g. dead and/or resorbed implants per total number of implants) Reproductive - Specific Developmental Abnormalities - eye/ear Reproductive - Specific Developmental Abnormalities - craniofacial (including nose and tongue) REFERENCE : TJADAB Teratology, The International Journal of Abnormal Development. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.1- 1968- Volume(issue)/page/year: 12,195,1975 TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Intravenous DOSE : 1800 mg/kg SEX/DURATION : female 8-16 day(s) after conception TOXIC EFFECTS : Reproductive - Fertility - abortion REFERENCE : TJADAB Teratology, The International Journal of Abnormal Development. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.1- 1968- Volume(issue)/page/year: 12,195,1975 TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Intravenous DOSE : 900 mg/kg SEX/DURATION : female 8-16 day(s) after conception TOXIC EFFECTS : Reproductive - Effects on Embryo or Fetus - fetal death REFERENCE : TJADAB Teratology, The International Journal of Abnormal Development. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.1- 1968- Volume(issue)/page/year: 12,195,1975 TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Intravenous DOSE : 90 mg/kg SEX/DURATION : female 8-16 day(s) after conception TOXIC EFFECTS : Reproductive - Fertility - post-implantation mortality (e.g. dead and/or resorbed implants per total number of implants) Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death, e.g., stunted fetus) REFERENCE : SEIJBO Senten Ijo. Congenital Anomalies. (Nippon Senten Ijo Gakkai, c/o Kinki Daigaku Igakubu Kaibagaku Kyoshitsu, 380 Nishiyama, Sayama-cho, Mirami-Kawachi-gun, Osaka-fu, Japan) V.1-26, 1960-86. For publisher information, see CGANE7. Volume(issue)/page/year: 15,238,1975 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - X6661 No. of Facilities: 10 (estimated) No. of Industries: 1 No. of Occupations: 2 No. of Employees: 7622 (estimated) No. of Female Employees: 7177 (estimated)