前往化源商城
入驻化源商城

品牌现货直购
供应商:我要出现这里



查看所有供应商和价格请点击:

38030-57-8生产厂家

38030-57-8价格

38030-57-8

38030-57-8结构式
38030-57-8结构式
  • 常用中文名:4-氧代-维A酸
  • 常用英文名:all-trans-4-Oxoretinoic acid
  • CAS号:38030-57-8
  • 分子式:C20H26O3
  • 分子量:314.41900
  • 相关类别: 天然产物 其他
  • 发布时间:2018-02-10 08:00:00
  • 更新时间:2024-01-02 18:07:07
  • all-trans-4-Oxoretinoic acid,是维生素A 的活性代谢物,可通过作用核维甲酸受体 (RARs) 来诱导基因转录。

化源商城直购

中文名 4-氧代-维A酸
英文名 all-trans-4-oxoretinoic acid
中文别名 4-氧代-全反式维甲酸
3,7-二甲基-9-(4-氧代-2,6,6-三甲基环己烯)-2,4,6,8-全反式壬四烯酸
4-氧代-视黄酸
维A酸-4-酮
英文别名 4-keto-Retinoic Acid
4-oxo-all-rans-retinoic acid
4-Oxoretinoic Acid
all-trans-4-Oxoretinoic Acid
4-oxo-all-trans-retinoic acid
all-trans 4-Keto Retinoic Acid
4-oxo-Retinoic acid
4-Ketoretinoic Acid
4-Oxo-atRA
4-Oxotretinoin
描述 all-trans-4-Oxoretinoic acid,是维生素A 的活性代谢物,可通过作用核维甲酸受体 (RARs) 来诱导基因转录。
相关类别
靶点

Human Endogenous Metabolite

体外研究 全反式-4-氧代氨基酸,维生素A的活性代谢产物,通过与核视黄酸受体(RARs)的结合诱导基因转录[1]。全反式-4-氧代氨基酸是视黄酸(RA)的生物活性几何异构体[2]。
参考文献

[1]. Topletz AR, et al. Induction of CYP26A1 by metabolites of retinoic acid: evidence that CYP26A1 is an important enzyme in the elimination of active retinoids. Mol Pharmacol. 2015;87(3):430-41.

[2]. Stahl W, et al. 4-oxo-retinoic acid is generated from its precursor canthaxanthin and enhances gap junctional communication in 10T1/2 cells. Adv Exp Med Biol. 1996;387:121-8.

密度 1.07g/cm3
沸点 509.9ºC at 760 mmHg
熔点 175-178°C (分解)
分子式 C20H26O3
分子量 314.41900
闪点 276.3ºC
精确质量 314.18800
PSA 54.37000
LogP 4.78160
折射率 1.565
储存条件 2-8℃

CHEMICAL IDENTIFICATION

RTECS NUMBER :
VH6599800
CHEMICAL NAME :
Retinoic acid, 4-oxo-
CAS REGISTRY NUMBER :
38030-57-8
LAST UPDATED :
199007
DATA ITEMS CITED :
5
MOLECULAR FORMULA :
C20-H26-O3
MOLECULAR WEIGHT :
314.46

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
DOSE :
100 mg/kg
SEX/DURATION :
female 11 day(s) after conception
TOXIC EFFECTS :
Reproductive - Specific Developmental Abnormalities - musculoskeletal system
REFERENCE :
TJADAB Teratology, The International Journal of Abnormal Development. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.1- 1968- Volume(issue)/page/year: 35,33A,1987
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
DOSE :
10 mg/kg
SEX/DURATION :
female 11 day(s) after conception
TOXIC EFFECTS :
Reproductive - Specific Developmental Abnormalities - musculoskeletal system
REFERENCE :
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year: 100,162,1989
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
DOSE :
20 mg/kg
SEX/DURATION :
female 8 day(s) after conception
TOXIC EFFECTS :
Reproductive - Fertility - post-implantation mortality (e.g. dead and/or resorbed implants per total number of implants)
REFERENCE :
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year: 95,122,1988
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
DOSE :
39 mg/kg
SEX/DURATION :
female 8 day(s) after conception
TOXIC EFFECTS :
Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death, e.g., stunted fetus)
REFERENCE :
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year: 95,122,1988
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
DOSE :
4900 ug/kg
SEX/DURATION :
female 8 day(s) after conception
TOXIC EFFECTS :
Reproductive - Specific Developmental Abnormalities - other developmental abnormalities
REFERENCE :
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year: 95,122,1988

~87%

38030-57-8结构式

38030-57-8

文献:Mironova; Leont'eva; Shevyakov; Alexeeva; Shvets; Demina; Krasnokutskaya; Finkel'shtein; Khodonov Russian Journal of Bioorganic Chemistry, 2002 , vol. 28, # 6 p. 487 - 493

~%

38030-57-8结构式

38030-57-8

文献:Rosenberger Journal of Organic Chemistry, 1982 , vol. 47, # 9 p. 1698 - 1701

~%

38030-57-8结构式

38030-57-8

文献:Rosenberger Journal of Organic Chemistry, 1982 , vol. 47, # 9 p. 1698 - 1701

~%

38030-57-8结构式

38030-57-8

文献:Aig, Edward; Focella, Antonino; Parrish, David R.; Rosenberger, Michael; Scott, John W.; Zenchoff, Gladys B. Synthetic Communications, 1987 , vol. 17, # 4 p. 419 - 430

~%

38030-57-8结构式

38030-57-8

文献:Aig, Edward; Focella, Antonino; Parrish, David R.; Rosenberger, Michael; Scott, John W.; Zenchoff, Gladys B. Synthetic Communications, 1987 , vol. 17, # 4 p. 419 - 430

~%

38030-57-8结构式

38030-57-8

文献:UNIVERSITY OF WASHINGTON Patent: US2008/249042 A1, 2008 ; Location in patent: Page/Page column 2; 27; 29; 31; Sheet 14/24; 24/24 ;

~%

38030-57-8结构式

38030-57-8

文献:Mironova; Leont'eva; Shevyakov; Alexeeva; Shvets; Demina; Krasnokutskaya; Finkel'shtein; Khodonov Russian Journal of Bioorganic Chemistry, 2002 , vol. 28, # 6 p. 487 - 493

~%

38030-57-8结构式

38030-57-8

文献:Rosenberger Journal of Organic Chemistry, 1982 , vol. 47, # 9 p. 1698 - 1701

~%

38030-57-8结构式

38030-57-8

文献:Aig, Edward; Focella, Antonino; Parrish, David R.; Rosenberger, Michael; Scott, John W.; Zenchoff, Gladys B. Synthetic Communications, 1987 , vol. 17, # 4 p. 419 - 430