180083-23-2

180083-23-2结构式

常用中文名：(2'-甲基-4'-(5-甲基-1,2,4-恶二唑-3-基)-[1,1'-二苯基]-4-基)(1'-甲基-6,7-二氢螺[呋喃并[2,3-f]吲哚-3,4'-哌啶]-5(2H)-基)甲酮
常用英文名：SB 224289 hydrochloride
CAS号：180083-23-2
分子式：C₃₂H₃₂N₄O₃
分子量：520.62
发布时间：2018-10-13 11:06:23
更新时间：2024-01-04 17:41:52
SB-224289是一种选择性5-HT1B受体拮抗剂,具有抗焦虑作用[1]。

中文名	[2'-甲基-4'-(5-甲基-1,2,4-恶二唑-3-基)[1,1'-联苯基]-4-基](2,5,6,7-四氢-1'-甲基螺[3H-呋喃并[2,3-F]吲哚-3,4'-哌啶]-5-基)甲酮
英文名	sb 224289
英文别名	(1'-Methyl-6,7-dihydro-5H-spiro[furo[2,3-f]indole-3,4'-piperidin]-5-yl)[2'-methyl-4'-(5-methyl-1,2,4-oxadiazol-3-yl)biphenyl-4-yl]methanone hydrochloride (1:1) 1'-Methyl-5-[[2'-methyl-4'-(5-methyl-1,2,4-oxadiazol-3-yl)biphenyl-4-yl]carbonyl]-2,3,6,7-tetrahydrospiro[furo[2,3-f]indole-3,4'-piperidine] hydrochloride Methanone, (6,7-dihydro-1'-methylspiro[2H-furo[2,3-f]indole-3(5H),4'-piperidin]-5-yl)[2'-methyl-4'-(5-methyl-1,2,4-oxadiazol-3-yl)[1,1'-biphenyl]-4-yl]-, hydrochloride (1:1) (1'-Methyl-6,7-dihydro-5H-spiro[furo[2,3-f]indole-3,4'-piperidin]-5-yl)[2'-methyl-4'-(5-methyl-1,2,4-oxadiazol-3-yl)-4-biphenylyl]methanone hydrochloride (1:1) [4-[2-methyl-4-(5-methyl-1,2,4-oxadiazol-3-yl)phenyl]phenyl]-(1'-methylspiro[6,7-dihydro-2H-furo[2,3-f]indole-3,4'-piperidine]-5-yl)methanone SB 224289 hydrochloride

描述	SB-224289是一种选择性5-HT1B受体拮抗剂,具有抗焦虑作用[1]。
相关类别	研究领域 >> 神经疾病信号通路 >> G 蛋白偶联受体/G 蛋白 >> 5-HT受体信号通路 >> 神经信号通路 >> 5-HT受体
参考文献	[1]. Cassilly CD, et al. SB-224289 Antagonizes the Antifungal Mechanism of the Marine Depsipeptide Papuamide A. PLoS One. 2016 May 16;11(5):e0154932.