(2'-甲基-4'-(5-甲基-1,2,4-恶二唑-3-基)-[1,1'-二苯基]-4-基)(1'-甲基-6,7-二氢螺[呋喃并[2,3-f]吲哚-3,4'-哌啶]-5(2H)-基)甲酮

• 常用名: (2'-甲基-4'-(5-甲基-1,2,4-恶二唑-3-基)-[1,1'-二苯基]-4-基)(1'-甲基-6,7-二氢螺[呋喃并[2,3-f]吲哚-3,4'-哌啶]-5(2H)-基)甲酮
• 英文名: SB 224289 hydrochloride
• CAS号: 180083-23-2
• 分子量: 520.62
• 密度: 1.34g/ml
• 沸点: N/A
• 分子式: C₃₂H₃₂N₄O₃
• 熔点: 280℃
• 闪点: N/A

用途

SB-224289是一种选择性5-HT1B受体拮抗剂,具有抗焦虑作用[1]。

名称

• 中文名: [2'-甲基-4'-(5-甲基-1,2,4-恶二唑-3-基)[1,1'-联苯基]-4-基](2,5,6,7-四氢-1'-甲基螺[3H-呋喃并[2,3-F]吲哚-3,4'-哌啶]-5-基)甲酮
• 英文名: sb 224289

生物活性

• 描述: SB-224289是一种选择性5-HT1B受体拮抗剂,具有抗焦虑作用[1]。
• 相关类别:
  研究领域 >> 神经疾病
  信号通路 >> G 蛋白偶联受体/G 蛋白 >> 5-HT受体
  信号通路 >> 神经信号通路 >> 5-HT受体
• 参考文献:

  [1]. Cassilly CD, et al. SB-224289 Antagonizes the Antifungal Mechanism of the Marine Depsipeptide Papuamide A. PLoS One. 2016 May 16;11(5):e0154932.

物理化学性质

• 密度: 1.34g/ml
• 熔点: 280℃
• 分子式: C₃₂H₃₂N₄O₃
• 分子量: 520.62
• 精确质量: 556.224121
• PSA: 71.70000
• LogP: 6.38400
• 储存条件: 室温，干燥，密封

安全信息

• 安全声明 (欧洲): 22-24/25
• WGK德国: 3

英文别名

• (1'-Methyl-6,7-dihydro-5H-spiro[furo[2,3-f]indole-3,4'-piperidin]-5-yl)[2'-methyl-4'-(5-methyl-1,2,4-oxadiazol-3-yl)biphenyl-4-yl]methanone hydrochloride (1:1)
• 1'-Methyl-5-[[2'-methyl-4'-(5-methyl-1,2,4-oxadiazol-3-yl)biphenyl-4-yl]carbonyl]-2,3,6,7-tetrahydrospiro[furo[2,3-f]indole-3,4'-piperidine] hydrochloride
• Methanone, (6,7-dihydro-1'-methylspiro[2H-furo[2,3-f]indole-3(5H),4'-piperidin]-5-yl)[2'-methyl-4'-(5-methyl-1,2,4-oxadiazol-3-yl)[1,1'-biphenyl]-4-yl]-, hydrochloride (1:1)
• (1'-Methyl-6,7-dihydro-5H-spiro[furo[2,3-f]indole-3,4'-piperidin]-5-yl)[2'-methyl-4'-(5-methyl-1,2,4-oxadiazol-3-yl)-4-biphenylyl]methanone hydrochloride (1:1)
• [4-[2-methyl-4-(5-methyl-1,2,4-oxadiazol-3-yl)phenyl]phenyl]-(1'-methylspiro[6,7-dihydro-2H-furo[2,3-f]indole-3,4'-piperidine]-5-yl)methanone
• SB 224289 hydrochloride