303-47-9

• 常用中文名：曲霉素A
• 常用英文名：Ochratoxin A
• CAS号：303-47-9
• 分子式：C₂₀H₁₈ClNO₆
• 分子量：403.813
• 发布时间：2018-07-25 16:43:56
• 更新时间：2024-01-02 10:55:36
• 赭曲霉毒素A是一种典型的曲霉属真菌毒素。它是谷物、咖啡、葡萄、葡萄酒、啤酒等中常见的次级代谢产物[1]。

名称

• 中文名: 曲霉素A
• 英文名: ochratoxin A
• 中文别名: 喹唑
• 英文别名: MFCD00078079; lanine; 3R,14S-Ochratoxin A; Phe-OTA; EINECS 206-143-7; Ochratoxin A,N-[[(3R)-5-Chloro-3,4-dihydro-8-hydroxy-3-methyl-1-oxo-1H-2-benzopyran-7-yl]carbonyl]-L-phenylalanine; bonyl]phenylalanine; L-Phenylalanine, N-[[(3R)-5-chloro-3,4-dihydro-8-hydroxy-3-methyl-1-oxo-1H-2-benzopyran-7-yl]carbonyl]-; Ponceau S Staining Solution; N-{[(3R)-5-Chloro-8-hydroxy-3-methyl-1-oxo-3,4-dihydro-1H-isochromen-7-yl]carbonyl}-L-phenylalanine; Ochratoxin A; Ochratoxin A(OTA)

物化性质

• 密度: 1.4±0.1 g/cm3
• 沸点: 632.4±55.0 °C at 760 mmHg
• 熔点: 169ºC
• 分子式: C₂₀H₁₈ClNO₆
• 分子量: 403.813
• 闪点: 336.3±31.5 °C
• 精确质量: 403.082275
• PSA: 112.93000
• LogP: 4.31
• 外观性状: 白色结晶固体
• 蒸汽压: 0.0±2.0 mmHg at 25°C
• 折射率: 1.628
• 储存条件:

  2-8°储存。

• 分子结构:

  1、 摩尔折射率：100.54

  2、 摩尔体积（m³/mol）：283.2

  3、 等张比容（90.2K）：794.3

  4、 表面张力（dyne/cm）：61.9

  5、 极化率（10 ^-24cm ³）：39.85

• 更多:

  一、物性数据

  性状：粉末结晶

  密度（g/mL,25/4℃）：不可用

  相对蒸汽密度（g/mL,空气=1）：不可用

  熔点（ºC）：169

  沸点（ºC,常压）：不可用

  沸点（ºC,5.2kPa）：不可用

  折射率：不可用

  闪点（ºC）：不可用

  比旋光度（º）：不可用

  自燃点或引燃温度（ºC）：不可用

  蒸气压（kPa,25ºC）：不可用

  饱和蒸气压（kPa,60ºC）：不可用

  燃烧热（KJ/mol）：不可用

  临界温度（ºC）：不可用

  临界压力（KPa）：不可用

  油水（辛醇/水）分配系数的对数值：不可用

  爆炸上限（%,V/V）：不可用

  爆炸下限（%,V/V）：不可用

  溶解性：溶于乙醇

生物活性

• 描述: 赭曲霉毒素A是一种典型的曲霉属真菌毒素。它是谷物、咖啡、葡萄、葡萄酒、啤酒等中常见的次级代谢产物[1]。
• 相关类别:
  研究领域 >> 其他
• 靶点:

  Human Endogenous Metabolite

• 参考文献:

  [1]. Hoehler D, et al. Induction of free radicals in hepatocytes, mitochondria and microsomes of rats by ochratoxin A and its analogs. Biochim Biophys Acta. 1997 Jun 27;1357(2):225-33.

MSDS

1.1 产品标识符 : 赭曲霉素 A 化学品俗名或商品名 1.2 鉴别的其他方法 N-[(3R)-(5-Chloro-8-hydroxy-3-methyl-1-oxo-7-isochromanyl)carbonyl]-L-phenylalanine 1.3 有关的确定了的物质或混合物的用途和建议不适合的用途 仅供科研用途，不作为药物、家庭备用药或其它用途。 模块2. 危险性概述 2.1 GHS分类 急性毒性, 经口 (类别2) 皮肤刺激 (类别3) 致癌性 (类别2) 致畸性 (类别2) 特异性靶器官系统毒性（反复接触）, 吸入 (类别2) 慢性的水体毒性 (类别4) 2.2 GHS 标记要素，包括预防性的陈述 危害类型象形图 信号词危险 危险申明 H300吞咽致命。 H316造成轻微皮肤刺激。 H351怀疑会致癌。 H361怀疑对生育能力或胎儿造成伤害。 H373长期或重复接触可能通过吸入对器官造成伤害。 H413可能对水生生物造成长期持续有害影响。 警告申明 预防 P201在使用前获取特别指示。 P202在读懂所有安全防范措施之前切勿操作。 P260不要吸入粉尘/ 烟/ 气体/ 烟雾/ 蒸汽/ 喷雾。 P264操作后彻底清洁皮肤。 P270使用本产品时不要进食、饮水或吸烟。 P273避免释放到环境中。 P281使用所需的个人防护设备。 措施 P301 + P310如果吞下去了: 立即呼救解毒中心或医生。 P308 + P313如接触到或有疑虑：求医/ 就诊。 P321具体治疗(见本标签上提供的急救指导)。 P330漱口。 P332 + P313如发生皮肤刺激：求医/ 就诊。 储存 P405存放处须加锁。 处理 P501将内容物/ 容器处理到得到批准的废物处理厂。 2.3 其它危害物 - 无 模块3. 成分/组成信息 3.1 物 质 : N-[(3R)-(5-Chloro-8-hydroxy-3-methyl-1-oxo-7-isochromanyl)carbonyl]-L- 别名 phenylalanine : 403.81 g/mol 分子量 成分浓度 (-)-Ochratoxin A - 化学文摘编号(CAS No.) 303-47-9 EC-编号206-143-7 Ethyl acetate 化学文摘编号(CAS No.) 141-78-61-3% EC-编号205-500-4 索引编号607-022-00-5 Hydrocarbon mixture C5-C8 Aliphates 化学文摘编号(CAS No.) 101316-46-51-3% EC-编号309-852-0 模块4. 急救措施 4.1 必要的急救措施描述 一般的建议 请教医生。 出示此安全技术说明书给到现场的医生看。 如果吸入 如果吸入,请将患者移到新鲜空气处。 如果停止了呼吸,给于人工呼吸。 请教医生。 在皮肤接触的情况下 用肥皂和大量的水冲洗。 立即将患者送往医院。 请教医生。 在眼睛接触的情况下 用水冲洗眼睛作为预防措施。 如果误服 切勿给失去知觉者从嘴里喂食任何东西。 用水漱口。 请教医生。 4.2 最重要的症状和影响，急性的和滞后的 据我们所知，此化学，物理和毒性性质尚未经完整的研究。 4.3 及时的医疗处理和所需的特殊处理的说明和指示 无数据资料 模块5. 消防措施 5.1 灭火介质 灭火方法及灭火剂 用水雾,耐醇泡沫,干粉或二氧化碳灭火。 5.2 源于此物质或混合物的特别的危害 碳氧化物, 氮氧化物, 氯化氢气体 5.3 给消防员的建议 如必要的话,戴自给式呼吸器去救火。 5.4 进一步的信息 无数据资料 模块6. 泄露应急处理 6.1 人员的预防,防护设备和紧急处理程序 戴呼吸罩。 防止粉尘的生成。 防止吸入蒸汽、气雾或气体。 保证充分的通风。 将人员撤离到安全区域。 避免吸入粉尘。 6.2 环境预防措施 在确保安全的前提下，采取措施防止进一步的泄漏或溢出。 不要让产物进入下水道。 防止排放到周围环境中。 6.3 抑制和清除溢出物的方法和材料 收集、处理泄漏物，不要产生灰尘。 扫掉和铲掉。 存放进适当的闭口容器中待处理。 6.4 参考其他部分 丢弃处理请参阅第13节。 模块7. 操作处置与储存 7.1 安全操作的注意事项 避免接触皮肤和眼睛。 防止粉尘和气溶胶生成。 在有粉尘生成的地方,提供合适的排风设备。 7.2 安全储存的条件,包括任何不兼容性 贮存在阴凉处。 容器保持紧闭，储存在干燥通风处。 建议的贮存温度： 2 - 8 °C 7.3 特定用途 无数据资料 模块8. 接触控制和个体防护 8.1 控制参数 最高容许浓度 成分化学文摘编 值控制参数基准 号(CAS No.) Ethyl acetate141-78-6 PC-200 mg/m3工作场所有害因素职业接触限值 - TWA化学有害因素 PC-300 mg/m3工作场所有害因素职业接触限值 - STEL化学有害因素 8.2 暴露控制 适当的技术控制 避免与皮肤、眼睛和衣服接触。 休息以前和操作过此产品之后立即洗手。 人身保护设备 眼/面保护 面罩與安全眼鏡请使用经官方标准如NIOSH (美国) 或 EN 166(欧盟) 检测与批准的设备防护眼部。 皮肤保护 戴手套取 手套在使用前必须受检查。 请使用合适的方法脱除手套(不要接触手套外部表面),避免任何皮肤部位接触此产品. 使用后请将被污染过的手套根据相关法律法规和有效的实验室规章程序谨慎处理. 请清洗并吹干双手 所选择的保护手套必须符合EU的89/686/EEC规定和从它衍生出来的EN 376标准。 身体保护 全套防化学试剂工作服, 防护设备的类型必须根据特定工作场所中的危险物的浓度和含量来选择。 呼吸系统防护 如危险性评测显示需要使用空气净化的防毒面具，请使用全面罩式多功能微粒防毒面具N100型（US ）或P3型（EN 143）防毒面具筒作为工程控制的候补。如果防毒面具是保护的唯一方式，则使用全面罩式送风防毒 面具。 呼吸器使用经过测试并通过政府标准如NIOSH（US）或CEN（EU）的呼吸器和零件。 模块9. 理化特性 9.1 基本的理化特性的信息 a) 外观与性状 形状: 粉末 颜色: 淡黄 b) 气味 无数据资料 c) 气味临界值 无数据资料 d) pH值 无数据资料 e) 熔点/凝固点 169.0 °C f) 起始沸点和沸程 无数据资料 g) 闪点 无数据资料 h) 蒸发速率 无数据资料 i) 可燃性(固体,气体) 无数据资料 j) 高的/低的燃烧性或爆炸性限度 无数据资料 k) 蒸汽压 无数据资料 l) 蒸汽密度 无数据资料 m) 相对密度 无数据资料 n) 水溶性 无数据资料 o) 分配系数：n-辛醇/水 辛醇--水的分配系数的对数值: 4.70 p) 自燃温度 无数据资料 q) 分解温度 无数据资料 r) 粘度 无数据资料 模块10. 稳定性和反应活性 10.1 反应性 无数据资料 10.2 化学稳定性 无数据资料 10.3 危险反应的可能性 无数据资料 10.4 应避免的条件 无数据资料 10.5 不兼容的材料 强氧化剂 10.6 危险的分解产物 其它分解产物 - 无数据资料 模块11. 毒理学资料 11.1 毒理学影响的信息 急性毒性 半数致死剂量 (LD50) 经口 - 大鼠 - 20.0 mg/kg 备注: 肺，胸，或者呼吸系统：慢性肺水肿 营养与总代谢：体重降低或体重增长减小。 皮肤腐蚀/刺激 无数据资料 严重眼损伤 / 眼刺激 无数据资料 呼吸道或皮肤过敏 无数据资料 生殖细胞诱变 实验室测试表明由诱变效应 致癌性 该产品是或包含被IARC, ACGIH, EPA, 和 NTP 列为致癌物的组分 在对动物的研究中,只有有限的致癌迹象 IARC: 2B - Group 2B: Possibly carcinogenic to humans ((-)-Ochratoxin A) 生殖毒性 实验室试验表明有畸胎生成效应 特异性靶器官系统毒性（一次接触） 无数据资料 特异性靶器官系统毒性（反复接触） 无数据资料 吸入危险 无数据资料 潜在的健康影响 吸入吸入有害。 可能引起呼吸道刺激。 摄入如果服入了可能会致死。 皮肤如果通过皮肤被吸收是有害的。 可能引起皮肤刺激。 眼睛可能引起眼睛刺激。 接触后的征兆和症状 据我们所知，此化学，物理和毒性性质尚未经完整的研究。 附加说明 化学物质毒性作用登记: 无数据资料 模块12. 生态学资料 12.1 毒性 无数据资料 12.2 持久存留性和降解性 无数据资料 12.3 生物蓄积性 无数据资料 12.4 土壤中的迁移 无数据资料 12.5 PBT 和 vPvB的结果评价 无数据资料 12.6 其它不利的影响 无数据资料 模块13. 废弃处置 13.1 废物处理方法 产品 将剩余的和未回收的溶液交给处理公司。 与易燃溶剂相溶或者相混合，在备有燃烧后处理和洗刷作用的化学焚化炉中燃烧 污染了的包装物 作为未用过的产品弃置。 模块14. 运输信息 14.1 UN编号 欧洲陆运危规: 3462国际海运危规: 3462国际空运危规: 3462 14.2 联合国（UN）规定的名称 欧洲陆运危规: TOXINS EXTRAC TED FROM LIVING SOURCES, SOLID, N.O.S. 国际海运危规: TOXINS, EXTRACTED FROM LIVING SOURCES, SOLID, N.O.S. 国际空运危规: Toxins, extracted from living sources, solid, n.o.s. (Ethyl acetate) 14.3 运输危险类别 欧洲陆运危规: 6.1国际海运危规: 6.1国际空运危规: 6.1 14.4 包裹组 欧洲陆运危规: II国际海运危规: II国际空运危规: II 14.5 环境危险 欧洲陆运危规: 否国际海运危规 海运污染物: 否国际空运危规: 否 14.6 对使用者的特别提醒 无数据资料 模块 15 - 法规信息 N/A 模块16 - 其他信息 N/A

毒性和生态

毒理学数据: 二、毒理学数据： 急性毒性：不可用。 生态学数据: 三、生态学数据： 1、其它有害作用：该物质对环境可能有危害，对水体应给予特别注意。 CHEMICAL IDENTIFICATION RTECS NUMBER : AY4375000 CHEMICAL NAME : Alanine, N-((5-chloro-8-hydroxy-3-methyl-1-oxo-7-isochromanyl) carbonyl)-3-phenyl-, (-)- CAS REGISTRY NUMBER : 303-47-9 BEILSTEIN REFERENCE NO. : 1301486 LAST UPDATED : 199803 DATA ITEMS CITED : 84 MOLECULAR FORMULA : C20-H18-Cl-N-O6 MOLECULAR WEIGHT : 403.84 WISWESSER LINE NOTATION : T66 BVOT&J D1 GG IVMYVQ1R& JQ HEALTH HAZARD DATA ACUTE TOXICITY DATA TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 20 mg/kg TOXIC EFFECTS : Lungs, Thorax, or Respiration - chronic pulmonary edema Nutritional and Gross Metabolic - weight loss or decreased weight gain TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 12600 ug/kg TOXIC EFFECTS : Behavioral - altered sleep time (including change in righting reflex) Gastrointestinal - ulceration or bleeding from stomach Skin and Appendages - hair TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 12750 ug/kg TOXIC EFFECTS : Behavioral - altered sleep time (including change in righting reflex) Gastrointestinal - ulceration or bleeding from stomach Skin and Appendages - hair TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Unreported SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 22 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 46 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 22 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 25710 ug/kg TOXIC EFFECTS : Behavioral - altered sleep time (including change in righting reflex) Gastrointestinal - ulceration or bleeding from stomach Skin and Appendages - hair TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Bird - chicken DOSE/DURATION : 3300 ug/kg TOXIC EFFECTS : Cardiac - pericarditis Liver - other changes Kidney, Ureter, Bladder - other changes TYPE OF TEST : LDLo - Lowest published lethal dose ROUTE OF EXPOSURE : Subcutaneous SPECIES OBSERVED : Bird - chicken DOSE/DURATION : 11 mg/kg TOXIC EFFECTS : Liver - hepatitis (hepatocellular necrosis), zonal TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Bird - quail DOSE/DURATION : 16500 ug/kg TOXIC EFFECTS : Behavioral - somnolence (general depressed activity) Behavioral - ataxia Nutritional and Gross Metabolic - weight loss or decreased weight gain TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Bird - duck DOSE/DURATION : 500 ug/kg TOXIC EFFECTS : Liver - fatty liver degeneration TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Bird - turkey DOSE/DURATION : 5900 ug/kg TOXIC EFFECTS : Behavioral - somnolence (general depressed activity) Behavioral - ataxia Nutritional and Gross Metabolic - weight loss or decreased weight gain TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Mammal - domestic DOSE/DURATION : 1 mg/kg TOXIC EFFECTS : Lungs, Thorax, or Respiration - acute pulmonary edema Liver - other changes TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 36050 ug/kg/2Y-I TOXIC EFFECTS : Kidney, Ureter, Bladder - changes in tubules (including acute renal failure, acute tubular necrosis) Kidney, Ureter, Bladder - other changes TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 46667 ug/kg/8W-I TOXIC EFFECTS : Liver - other changes Blood - changes in serum composition (e.g. TP, bilirubin, cholesterol) Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - multiple enzyme effects TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 8125 ug/kg/13W-I TOXIC EFFECTS : Kidney, Ureter, Bladder - changes in bladder weight TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 8 mg/kg/2W-C TOXIC EFFECTS : Liver - changes in liver weight Kidney, Ureter, Bladder - urine volume decreased Blood - changes in serum composition (e.g. TP, bilirubin, cholesterol) TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 40 mg/kg/10D-I TOXIC EFFECTS : Blood - changes in other cell count (unspecified) Blood - changes in erythrocyte (RBC) count Blood - changes in leukocyte (WBC) count TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 3750 ug/kg/5D-I TOXIC EFFECTS : Kidney, Ureter, Bladder - other changes in urine composition Kidney, Ureter, Bladder - other changes Nutritional and Gross Metabolic - weight loss or decreased weight gain TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 40 mg/kg/8D-I TOXIC EFFECTS : Endocrine - changes in thymus weight Blood - changes in bone marrow (not otherwise specified) Blood - changes in other cell count (unspecified) TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 30 mg/kg/6W-I TOXIC EFFECTS : Blood - changes in serum composition (e.g. TP, bilirubin, cholesterol) Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - phosphatases Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - dehydrogenases TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Mammal - dog DOSE/DURATION : 2800 ug/kg/14D-I TOXIC EFFECTS : Sense Organs and Special Senses (Eye) - conjunctive irritation Kidney, Ureter, Bladder - other changes in urine composition Blood - other changes TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Mammal - pig DOSE/DURATION : 6 mg/kg/6D-I TOXIC EFFECTS : Kidney, Ureter, Bladder - changes in tubules (including acute renal failure, acute tubular necrosis) Blood - changes in spleen Related to Chronic Data - death TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Mammal - pig DOSE/DURATION : 4880 ug/kg/17W-C TOXIC EFFECTS : Kidney, Ureter, Bladder - changes in both tubules and glomeruli Kidney, Ureter, Bladder - other changes in urine composition Nutritional and Gross Metabolic - weight loss or decreased weight gain TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Mammal - pig DOSE/DURATION : 13200 ug/kg/22D-C TOXIC EFFECTS : Behavioral - somnolence (general depressed activity) Kidney, Ureter, Bladder - changes in tubules (including acute renal failure, acute tubular necrosis) Related to Chronic Data - death TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - guinea pig DOSE/DURATION : 140 mg/kg/14D-I TOXIC EFFECTS : Kidney, Ureter, Bladder - changes in tubules (including acute renal failure, acute tubular necrosis) Biochemical - Metabolism (Intermediary) - Plasma proteins not involving coagulation Related to Chronic Data - death TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 36050 ug/kg/2Y-C TOXIC EFFECTS : Tumorigenic - Carcinogenic by RTECS criteria Kidney, Ureter, Bladder - Kidney tumors TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 2216 mg/kg/44W-C TOXIC EFFECTS : Tumorigenic - Carcinogenic by RTECS criteria Liver - tumors Kidney, Ureter, Bladder - Kidney tumors TYPE OF TEST : TD - Toxic dose (other than lowest) ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 1478 mg/kg/44W-C TOXIC EFFECTS : Tumorigenic - neoplastic by RTECS criteria Liver - tumors TYPE OF TEST : TD - Toxic dose (other than lowest) ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 1478 mg/kg/44W-C TOXIC EFFECTS : Tumorigenic - equivocal tumorigenic agent by RTECS criteria Liver - tumors TYPE OF TEST : TD - Toxic dose (other than lowest) ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 3504 mg/kg/2Y-C TOXIC EFFECTS : Tumorigenic - Carcinogenic by RTECS criteria Kidney, Ureter, Bladder - Kidney tumors TYPE OF TEST : TD - Toxic dose (other than lowest) ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 2 gm/kg/30W-C TOXIC EFFECTS : Tumorigenic - equivocal tumorigenic agent by RTECS criteria Liver - tumors Kidney, Ureter, Bladder - Kidney tumors TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Oral DOSE : 8 mg/kg SEX/DURATION : female 7-10 day(s) after conception TOXIC EFFECTS : Reproductive - Fertility - post-implantation mortality (e.g. dead and/or resorbed implants per total number of implants) Reproductive - Effects on Embryo or Fetus - fetal death Reproductive - Specific Developmental Abnormalities - musculoskeletal system TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Oral DOSE : 5 mg/kg SEX/DURATION : female 8-9 day(s) after conception TOXIC EFFECTS : Reproductive - Effects on Newborn - live birth index (measured after birth) Reproductive - Effects on Newborn - viability index (e.g., # alive at day 4 per # born alive) TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Oral DOSE : 7500 ug/kg SEX/DURATION : female 6-15 day(s) after conception TOXIC EFFECTS : Reproductive - Fertility - post-implantation mortality (e.g. dead and/or resorbed implants per total number of implants) Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death, e.g., stunted fetus) Reproductive - Specific Developmental Abnormalities - urogenital system TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Oral DOSE : 1 mg/kg SEX/DURATION : female 11-14 day(s) after conception TOXIC EFFECTS : Reproductive - Effects on Newborn - behavioral TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Oral DOSE : 10 mg/kg SEX/DURATION : female 6-15 day(s) after conception TOXIC EFFECTS : Reproductive - Specific Developmental Abnormalities - eye/ear Reproductive - Specific Developmental Abnormalities - cardiovascular (circulatory) system TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Oral DOSE : 5 mg/kg SEX/DURATION : female 6-15 day(s) after conception TOXIC EFFECTS : Reproductive - Specific Developmental Abnormalities - homeostasis Reproductive - Specific Developmental Abnormalities - musculoskeletal system TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Oral DOSE : 8 mg/kg SEX/DURATION : female 11-14 day(s) after conception TOXIC EFFECTS : Reproductive - Effects on Embryo or Fetus - extra-embryonic structures (e.g., placenta, umbilical cord) Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death, e.g., stunted fetus) TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Intraperitoneal DOSE : 35 mg/kg SEX/DURATION : female 6-12 day(s) after conception TOXIC EFFECTS : Reproductive - Maternal Effects - ovaries, fallopian tubes Reproductive - Fertility - post-implantation mortality (e.g. dead and/or resorbed implants per total number of implants) TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Intraperitoneal DOSE : 40 mg/kg SEX/DURATION : male 8 day(s) pre-mating TOXIC EFFECTS : Reproductive - Paternal Effects - testes, epididymis, sperm duct Reproductive - Paternal Effects - prostate, seminal vesicle, Cowper's gland, accessory glands TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Subcutaneous DOSE : 1750 ug/kg SEX/DURATION : female 7 day(s) after conception TOXIC EFFECTS : Reproductive - Specific Developmental Abnormalities - Central Nervous System Reproductive - Specific Developmental Abnormalities - body wall Reproductive - Specific Developmental Abnormalities - gastrointestinal system TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Subcutaneous DOSE : 1750 ug/kg SEX/DURATION : female 7 day(s) after conception TOXIC EFFECTS : Reproductive - Fertility - post-implantation mortality (e.g. dead and/or resorbed implants per total number of implants) Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death, e.g., stunted fetus) TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Subcutaneous DOSE : 1750 ug/kg SEX/DURATION : female 6 day(s) after conception TOXIC EFFECTS : Reproductive - Specific Developmental Abnormalities - musculoskeletal system Reproductive - Specific Developmental Abnormalities - urogenital system TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Subcutaneous DOSE : 1750 ug/kg SEX/DURATION : female 5 day(s) after conception TOXIC EFFECTS : Reproductive - Specific Developmental Abnormalities - eye/ear TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Subcutaneous DOSE : 1750 ug/kg SEX/DURATION : female 7 day(s) after conception TOXIC EFFECTS : Reproductive - Fertility - post-implantation mortality (e.g. dead and/or resorbed implants per total number of implants) Reproductive - Fertility - litter size (e.g. # fetuses per litter; measured before birth) Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death, e.g., stunted fetus) TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Oral DOSE : 3750 ug/kg SEX/DURATION : female 15-17 day(s) after conception TOXIC EFFECTS : Reproductive - Effects on Newborn - growth statistics (e.g.%, reduced weight gain) Reproductive - Effects on Newborn - behavioral TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Oral DOSE : 3 mg/kg SEX/DURATION : female 15 day(s) after conception TOXIC EFFECTS : Reproductive - Effects on Embryo or Fetus - cytological changes (including somatic cell genetic material) Reproductive - Specific Developmental Abnormalities - Central Nervous System TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Oral DOSE : 3 mg/kg SEX/DURATION : female 8 day(s) after conception TOXIC EFFECTS : Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death, e.g., stunted fetus) Reproductive - Specific Developmental Abnormalities - musculoskeletal system TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Oral DOSE : 7 mg/kg SEX/DURATION : female 7-13 day(s) after conception TOXIC EFFECTS : Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death, e.g., stunted fetus) Reproductive - Effects on Embryo or Fetus - fetal death Reproductive - Specific Developmental Abnormalities - musculoskeletal system TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Oral DOSE : 1 mg/kg SEX/DURATION : female 9 day(s) after conception TOXIC EFFECTS : Reproductive - Specific Developmental Abnormalities - Central Nervous System Reproductive - Specific Developmental Abnormalities - eye/ear TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Oral DOSE : 3 mg/kg SEX/DURATION : female 8 day(s) after conception TOXIC EFFECTS : Reproductive - Specific Developmental Abnormalities - craniofacial (including nose and tongue) Reproductive - Effects on Newborn - live birth index (measured after birth) TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Intraperitoneal DOSE : 2 mg/kg SEX/DURATION : female 10 day(s) after conception TOXIC EFFECTS : Reproductive - Specific Developmental Abnormalities - Central Nervous System Reproductive - Effects on Newborn - viability index (e.g., # alive at day 4 per # born alive) Reproductive - Effects on Newborn - growth statistics (e.g.%, reduced weight gain) TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Intraperitoneal DOSE : 3 mg/kg SEX/DURATION : female 11 day(s) after conception TOXIC EFFECTS : Reproductive - Effects on Embryo or Fetus - cytological changes (including somatic cell genetic material) Reproductive - Effects on Embryo or Fetus - other effects to embryo TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Intraperitoneal DOSE : 5 mg/kg SEX/DURATION : female 8 day(s) after conception TOXIC EFFECTS : Reproductive - Specific Developmental Abnormalities - eye/ear Reproductive - Specific Developmental Abnormalities - Central Nervous System TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Intraperitoneal DOSE : 2 mg/kg SEX/DURATION : female 8 day(s) after conception TOXIC EFFECTS : Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death, e.g., stunted fetus) Reproductive - Specific Developmental Abnormalities - Central Nervous System Reproductive - Specific Developmental Abnormalities - craniofacial (including nose and tongue) TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Intraperitoneal DOSE : 4 mg/kg SEX/DURATION : female 8 day(s) after conception TOXIC EFFECTS : Reproductive - Fertility - post-implantation mortality (e.g. dead and/or resorbed implants per total number of implants) TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Intraperitoneal DOSE : 5 mg/kg SEX/DURATION : female 7 day(s) after conception TOXIC EFFECTS : Reproductive - Specific Developmental Abnormalities - craniofacial (including nose and tongue) Reproductive - Specific Developmental Abnormalities - musculoskeletal system Reproductive - Effects on Embryo or Fetus - fetal death TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Intraperitoneal DOSE : 7500 ug/kg SEX/DURATION : female 8 day(s) after conception TOXIC EFFECTS : Reproductive - Specific Developmental Abnormalities - Central Nervous System TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Intraperitoneal DOSE : 20 mg/kg SEX/DURATION : female 9 day(s) after conception TOXIC EFFECTS : Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death, e.g., stunted fetus) TYPE OF TEST : DNA damage TYPE OF TEST : DNA damage TYPE OF TEST : DNA adduct MUTATION DATA TYPE OF TEST : DNA inhibition TEST SYSTEM : Mammal - species unspecified Kidney DOSE/DURATION : 50 umol/L REFERENCE : TOXIA6 Toxicon. (Pergamon Press Ltd., Headington Hill Hall, Oxford OX3 OBW, UK) V.1- 1962- Volume(issue)/page/year: (Suppl 3),353,1983 *** REVIEWS *** IARC Cancer Review:Animal Limited Evidence IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- Volume(issue)/page/year: 31,191,1983 IARC Cancer Review:Animal Sufficient Evidence IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- Volume(issue)/page/year: 56,489,1993 IARC Cancer Review:Human Inadequate Evidence IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- Volume(issue)/page/year: 31,191,1983 IARC Cancer Review:Human Inadequate Evidence IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- Volume(issue)/page/year: 56,489,1993 IARC Cancer Review:Group 2B IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- Volume(issue)/page/year: 56,489,1993 TOXICOLOGY REVIEW JAVMA4 Journal of the American Veterinary Medical Association. (American Veterinary Medical Assoc., 930 N. Meacham Rd., Schaumburg, IL 60196) V.48- 1915- Volume(issue)/page/year: 163,1269,1973 TOXICOLOGY REVIEW PMDCAY Progress in Medical Chemistry. (Elsevier Science Pub. Co., Inc., 52 Vanderbilt Ave., New York, NY 10017) V.1- 1961- Volume(issue)/page/year: 10,85,1974

安全

• 符号: GHS06, GHS08
• 信号词: Danger
• 危害声明: H300-H351-H413
• 警示性声明: P264-P281-P301 + P310
• 个人防护装备: Eyeshields;Faceshields;full-face particle respirator type N100 (US);Gloves;respirator cartridge type N100 (US);type P1 (EN143) respirator filter;type P3 (EN 143) respirator cartridges
• 危害码 (欧洲): T: Toxic;T+: Very toxic;Xn: Harmful;F: Flammable;
• 风险声明 (欧洲): 45-46-61-26/27/28-36-20/21/22-11-40-28-39/23/24/25-23/24/25-65-48/23/24/25-36/38
• 安全声明 (欧洲): 53-22-36/37/39-45-36-26-16-36/37-28-62
• 危险品运输编码: UN 3462 6
• RTECS号: AY4375000
• 危险类别: 6.1(a)

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