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106017-08-7

106017-08-7结构式
106017-08-7结构式

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中文名 盐酸芦氟沙星
英文名 rufloxacin hydrochloride
中文别名 2,3-二氢-9-氟-10-(4-甲基-1-哌嗪基)-7-氧代-7H-吡啶并[1,2,3-de][1,4]苯并噻嗪-6-羧酸盐酸盐
英文别名 7H-Pyrido[1,2,3-de]-1,4-benzothiazine-6-carboxylicacid,9-fluoro-2,3-dihydro-10-(4-methyl-1-piperazinyl)-7-oxo-,hydrochloride(1:1)
MF-934
MFCD00912283
9-fluoro-10-(4-methyl-1-piperazinyl)-7-oxo-2,3-dihydro-7H-pyrido[1,2,3-de][1,4]benzothiazine-6-carboxylic acid hydrochloride
7H-Pyrido(1,2,3-de)(1,4)benzothiazine-6-carboxylic acid,2,3-dihydro-9-fluoro-10-(4-methyl-1-piperazinyl)-7-oxo-,monohydrochloride
Rufloxacin (hydrochloride)
描述 Rufloxacin hydrochloride (MF-934 hydrochloride) 是一种喹诺酮类抗菌剂,作用于人单核细胞,抑制B细胞分化, 且制剂拓扑异构酶抑。
相关类别
沸点 574.6ºC at 760mmHg
熔点 322-324ºC
分子式 C17H19ClFN3O3S
分子量 399.86700
闪点 301.3ºC
精确质量 399.08200
PSA 91.08000
LogP 2.50120
储存条件 2-8℃

CHEMICAL IDENTIFICATION

RTECS NUMBER :
UU8174500
CHEMICAL NAME :
7H-Pyrido(1,2,3-de)(1,4)benzothiazine-6-carboxylic acid, 2,3-dihydro-9-fluoro-10-(4-methyl-1- piperazinyl)-7-oxo-, monohydrochloride
CAS REGISTRY NUMBER :
106017-08-7
LAST UPDATED :
198709
DATA ITEMS CITED :
4
MOLECULAR FORMULA :
C17-H18-F-N3-O3-S.Cl-H
MOLECULAR WEIGHT :
399.90

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
501 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
JMCMAR Journal of Medicinal Chemistry. (American Chemical Soc., Distribution Office Dept. 223, POB POB 57136, West End Stn., Washington, DC 20037) V.6- 1963- Volume(issue)/page/year: 30,465,1987
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
285 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
JMCMAR Journal of Medicinal Chemistry. (American Chemical Soc., Distribution Office Dept. 223, POB POB 57136, West End Stn., Washington, DC 20037) V.6- 1963- Volume(issue)/page/year: 30,465,1987
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
224 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
JMCMAR Journal of Medicinal Chemistry. (American Chemical Soc., Distribution Office Dept. 223, POB POB 57136, West End Stn., Washington, DC 20037) V.6- 1963- Volume(issue)/page/year: 30,465,1987
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rabbit
DOSE/DURATION :
660 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
JMCMAR Journal of Medicinal Chemistry. (American Chemical Soc., Distribution Office Dept. 223, POB POB 57136, West End Stn., Washington, DC 20037) V.6- 1963- Volume(issue)/page/year: 30,465,1987

海关编码 2942000000

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文献:Mediolanum Farmaceutici S.p.A. Patent: US5221741 A1, 1993 ;

~88%

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文献:Cecchetti; Fravolini; Schiaffella Synthetic Communications, 1991 , vol. 21, # 22 p. 2301 - 2308

~%

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文献:Synthetic Communications, , vol. 21, # 22 p. 2301 - 2308

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文献:Synthetic Communications, , vol. 21, # 22 p. 2301 - 2308

~%

106017-08-7结构式

106017-08-7

文献:Synthetic Communications, , vol. 21, # 22 p. 2301 - 2308
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海关编码 2942000000