6870-67-3

• 常用中文名：夾可鹼
• 常用英文名：Jacobine
• CAS号：6870-67-3
• 分子式：C₁₈H₂₅NO₆
• 分子量：351.39400
• 相关类别： 研究领域 其他
• 发布时间：2018-03-19 08:00:00
• 更新时间：2024-01-02 10:46:34
• Jacobine是来自千里光[1]的吡咯里西啶生物碱(PA)。Jacobine对蓟马的二龄幼虫具有活性[2]。

名称

• 中文名: 夾可鹼
• 英文名: Jacobine
• 英文别名: (15R,20S)-15,20-Dihydro-15,20-epoxy-12-hydroxysenecionan-11,16-dione

物化性质

• 密度: 1.33g/cm3
• 沸点: 574.1ºC at 760 mmHg
• 熔点: 228ºC
• 分子式: C₁₈H₂₅NO₆
• 分子量: 351.39400
• 闪点: 301ºC
• 精确质量: 351.16800
• PSA: 88.60000
• LogP: 0.34190
• 折射率: 1.583
• 储存条件: 2-8°C， 密封， 干燥

生物活性

• 描述: Jacobine是来自千里光[1]的吡咯里西啶生物碱(PA)。Jacobine对蓟马的二龄幼虫具有活性[2]。
• 相关类别:
  研究领域 >> 其他
  信号通路 >> 其他 >> 其他
• 体外研究: 吡咯里西啶生物碱(PAs)在植物浓度下平均降低蓟马存活率21%。结构相关的PAs对蓟马的存活有不同的影响。无PA碱比相应的PA N-氧化物更能降低蓟马的存活率[1][2]。
• 参考文献:

  [1]. Xiaojie Liu,et al.The effect of structurally related metabolites on insect herbivores: A case study on pyrrolizidine alkaloids and western flower thrips.Phytochemistry. 2017 Jun;138:93-103.

  [2]. Mirka Macel,et al. Variation in pyrrolizidine alkaloid patterns of Senecio jacobaea. Phytochemistry. 2004 Apr;65(7):865-73.

毒性和生态

CHEMICAL IDENTIFICATION RTECS NUMBER : NY5775000 CHEMICAL NAME : Jacobine CAS REGISTRY NUMBER : 6870-67-3 BEILSTEIN REFERENCE NO. : 0054580 LAST UPDATED : 199612 DATA ITEMS CITED : 10 MOLECULAR FORMULA : C18-H25-N-O6 MOLECULAR WEIGHT : 351.44 WISWESSER LINE NOTATION : T55-12- 1A Q EN IOVX OVO BUTJ M1 NQ N1 K-& BT3OX CHJ C1 HEALTH HAZARD DATA ACUTE TOXICITY DATA TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 77 mg/kg TOXIC EFFECTS : Behavioral - somnolence (general depressed activity) Behavioral - convulsions or effect on seizure threshold Lungs, Thorax, or Respiration - respiratory stimulation TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Unreported SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 60 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value TYPE OF TEST : Sex chromosome loss and nondisjunction TYPE OF TEST : DNA damage MUTATION DATA TYPE OF TEST : Unscheduled DNA synthesis TEST SYSTEM : Rodent - rat Liver DOSE/DURATION : 1 umol/L REFERENCE : CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut Sts., Philadelphia, PA 19106) V.1- 1941- Volume(issue)/page/year: 45,3125,1985 *** REVIEWS *** IARC Cancer Review:Animal Inadequate Evidence IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- Volume(issue)/page/year: 10,275,1976 IARC Cancer Review:Human No Adequate Data IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- Volume(issue)/page/year: 10,275,1976 IARC Cancer Review:Group 3 IMSUDL IARC Monographs, Supplement. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) No.1- 1979- Volume(issue)/page/year: 7,56,1987 TOXICOLOGY REVIEW CTRRDO Cancer Treatment Reports. (Washington, DC) V.60-71, 1976-87. For publisher information, see JNCIEQ. Volume(issue)/page/year: 60,1171,1976

安全

• 危险品运输编码: UN 1544
• 包装等级: III
• 危险类别: 6.1(b)