94-78-0

• 常用中文名：非那吡啶
• 常用英文名：3-(Phenylazo)-2,6-pyridinediamine
• CAS号：94-78-0
• 分子式：C₁₁H₁₁N₅
• 分子量：213.23900
• 相关类别： 原料药 泌尿系统用药 利尿药
• 发布时间：2018-09-19 19:11:54
• 更新时间：2024-01-03 11:04:59
• 非那吡啶对泌尿道有局部镇痛作用,通常用于缓解由泌尿道感染、手术或泌尿道损伤引起的疼痛、刺激、不适或紧迫感[1]。

名称

• 中文名: 非那吡啶
• 英文名: phenazopyridine
• 中文别名: 3-苯氮杂-2,6-二氨基吡啶
• 英文别名: Baridium; Pyridium; 3-Phenylazo-pyridin-2,6-diyldiamin; Viridium; 2,6-diamino-3-(phenylazo)pyridine; Sedural; Pyridiate; Gastracid; Urodine; 3-phenylazo-pyridine-2,6-diamine; Urogesic; Geridium; 3-phenyldiazenylpyridine-2,6-diamine

物化性质

• 密度: 1.32g/cm3
• 沸点: 442.3ºC at 760mmHg
• 熔点: 235 - 240ºC
• 分子式: C₁₁H₁₁N₅
• 分子量: 213.23900
• 精确质量: 213.10100
• PSA: 89.65000
• LogP: 3.82380
• 外观性状: 暗红色至紫罗兰色结晶粉末
• 折射率: 1.6880 (estimate)
• 储存条件: 20°C，惰性气体

生物活性

• 描述: 非那吡啶对泌尿道有局部镇痛作用,通常用于缓解由泌尿道感染、手术或泌尿道损伤引起的疼痛、刺激、不适或紧迫感[1]。
• 相关类别:
  研究领域 >> 其他
  信号通路 >> 其他 >> 其他
• 参考文献:

  [1]. Norris RD, et al. A prospective, randomized, double-blinded placebo-controlled comparison of extended release oxybutynin versus phenazopyridine for the management of postoperative ureteral stent discomfort. Urology. 2008 May;71(5):792-5.

毒性和生态

CHEMICAL IDENTIFICATION RTECS NUMBER : US7700000 CHEMICAL NAME : Pyridine, 2,6-diamino-3-(phenylazo)- CAS REGISTRY NUMBER : 94-78-0 BEILSTEIN REFERENCE NO. : 0184497 LAST UPDATED : 199612 DATA ITEMS CITED : 6 MOLECULAR FORMULA : C11-H11-N5 MOLECULAR WEIGHT : 213.27 WISWESSER LINE NOTATION : T6NJ BZ CNUNR& FZ HEALTH HAZARD DATA ACUTE TOXICITY DATA TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 560 mg/kg TOXIC EFFECTS : Behavioral - somnolence (general depressed activity) Lungs, Thorax, or Respiration - structural or functional change in trachea or bronchi Lungs, Thorax, or Respiration - dyspnea REFERENCE : JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year: 51,200,1934 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 580 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : PAHEAA Pharmaceutica Acta Helvetiae. (Schweizerische Apothekerzeitung, Postfach 3006, CH3000 Bern, 7, Switzerland) V.1- 1926- Volume(issue)/page/year: 35,423,1960 ** TUMORIGENIC DATA ** TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Implant SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 80 mg/kg TOXIC EFFECTS : Tumorigenic - neoplastic by RTECS criteria Kidney, Ureter, Bladder - tumors REFERENCE : BJCAAI British Journal of Cancer. (Macmillan Press Ltd., Houndmills, Basingstoke, Hants. RG21 2XS, UK) V.1- 1947- Volume(issue)/page/year: 11,212,1957 *** REVIEWS *** IARC Cancer Review:Human No Adequate Data IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- Volume(issue)/page/year: 8,117,1975 IARC Cancer Review:Animal Inadequate Evidence IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- Volume(issue)/page/year: 8,117,1975 TOXICOLOGY REVIEW AEHLAU Archives of Environmental Health. (Heldref Pub., 4000 Albemarle St., NW, Washington, DC 20016) V.1- 1960- Volume(issue)/page/year: 23,6,1971

安全

• 危害码 (欧洲): Xi
• 海关编码: 2933399090

合成路线

136-40-3 ~91% 94-78-0

文献：PINNACLE PHARMACEUTICALS, INC.; HECHT, Sidney; FAHMI, Nour, Eddine; ROY, Samir, D.; BONNEVILLE, George Patent: WO2010/71878 A1, 2010 ; Location in patent: Page/Page column 39-40 ;

100-34-5 ~% 94-78-0

文献：Tschitschibabin; Seide Zhurnal Russkago Fiziko-Khimicheskago Obshchestva, 1920 , vol. 50, p. 528 Chem. Zentralbl., 1923 , vol. 94, # III p. 1022

上下游产品

上游产品  2
136-40-3 100-34-5
下游产品  2
4318-79-0 29817-76-3

海关

海关编码	2933399090
中文概述	2933399090. 其他结构含非稠合吡啶环的化合物. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:20.0%
申报要素	品名, 成分含量, 用途, 乌洛托品请注明外观, 6－己内酰胺请注明外观, 签约日期
Summary	2933399090. other compounds containing an unfused pyridine ring (whether or not hydrogenated) in the structure. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%