94-78-0

94-78-0 structure
94-78-0 structure
  • Name: 3-(Phenylazo)-2,6-pyridinediamine
  • Chemical Name: phenazopyridine
  • CAS Number: 94-78-0
  • Molecular Formula: C11H11N5
  • Molecular Weight: 213.23900
  • Catalog: API Urinary system medication Diuretic
  • Create Date: 2018-09-19 19:11:54
  • Modify Date: 2024-01-03 11:04:59
  • Phenazopyridine has a local analgesic effect on the urinary tract, often used to alleviate the pain, irritation, discomfort, or urgency caused by urinary tract infections, surgery, or injury to the urinary tract[1].

Name phenazopyridine
Synonyms Baridium
Pyridium
3-Phenylazo-pyridin-2,6-diyldiamin
Viridium
2,6-diamino-3-(phenylazo)pyridine
Sedural
Pyridiate
Gastracid
Urodine
3-phenylazo-pyridine-2,6-diamine
Urogesic
Geridium
3-phenyldiazenylpyridine-2,6-diamine
Description Phenazopyridine has a local analgesic effect on the urinary tract, often used to alleviate the pain, irritation, discomfort, or urgency caused by urinary tract infections, surgery, or injury to the urinary tract[1].
Related Catalog
References

[1]. Norris RD, et al. A prospective, randomized, double-blinded placebo-controlled comparison of extended release oxybutynin versus phenazopyridine for the management of postoperative ureteral stent discomfort. Urology. 2008 May;71(5):792-5.

Density 1.32g/cm3
Boiling Point 442.3ºC at 760mmHg
Melting Point 235 - 240ºC
Molecular Formula C11H11N5
Molecular Weight 213.23900
Exact Mass 213.10100
PSA 89.65000
LogP 3.82380
Index of Refraction 1.6880 (estimate)

CHEMICAL IDENTIFICATION

RTECS NUMBER :
US7700000
CHEMICAL NAME :
Pyridine, 2,6-diamino-3-(phenylazo)-
CAS REGISTRY NUMBER :
94-78-0
BEILSTEIN REFERENCE NO. :
0184497
LAST UPDATED :
199612
DATA ITEMS CITED :
6
MOLECULAR FORMULA :
C11-H11-N5
MOLECULAR WEIGHT :
213.27
WISWESSER LINE NOTATION :
T6NJ BZ CNUNR& FZ

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
560 mg/kg
TOXIC EFFECTS :
Behavioral - somnolence (general depressed activity) Lungs, Thorax, or Respiration - structural or functional change in trachea or bronchi Lungs, Thorax, or Respiration - dyspnea
REFERENCE :
JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year: 51,200,1934
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
580 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
PAHEAA Pharmaceutica Acta Helvetiae. (Schweizerische Apothekerzeitung, Postfach 3006, CH3000 Bern, 7, Switzerland) V.1- 1926- Volume(issue)/page/year: 35,423,1960 ** TUMORIGENIC DATA **
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Implant
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
80 mg/kg
TOXIC EFFECTS :
Tumorigenic - neoplastic by RTECS criteria Kidney, Ureter, Bladder - tumors
REFERENCE :
BJCAAI British Journal of Cancer. (Macmillan Press Ltd., Houndmills, Basingstoke, Hants. RG21 2XS, UK) V.1- 1947- Volume(issue)/page/year: 11,212,1957 *** REVIEWS *** IARC Cancer Review:Human No Adequate Data IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- Volume(issue)/page/year: 8,117,1975 IARC Cancer Review:Animal Inadequate Evidence IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- Volume(issue)/page/year: 8,117,1975 TOXICOLOGY REVIEW AEHLAU Archives of Environmental Health. (Heldref Pub., 4000 Albemarle St., NW, Washington, DC 20016) V.1- 1960- Volume(issue)/page/year: 23,6,1971
Hazard Codes Xi
HS Code 2933399090

~91%

94-78-0 structure

94-78-0

Literature: PINNACLE PHARMACEUTICALS, INC.; HECHT, Sidney; FAHMI, Nour, Eddine; ROY, Samir, D.; BONNEVILLE, George Patent: WO2010/71878 A1, 2010 ; Location in patent: Page/Page column 39-40 ;

~%

94-78-0 structure

94-78-0

Literature: Tschitschibabin; Seide Zhurnal Russkago Fiziko-Khimicheskago Obshchestva, 1920 , vol. 50, p. 528 Chem. Zentralbl., 1923 , vol. 94, # III p. 1022
HS Code 2933399090
Summary 2933399090. other compounds containing an unfused pyridine ring (whether or not hydrogenated) in the structure. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%