124937-52-6

• 常用中文名：酒石酸托特罗定
• 常用英文名：Tolterodine tartrate
• CAS号：124937-52-6
• 分子式：C₂₆H₃₇NO₇
• 分子量：475.574
• 相关类别： 生物化工 抑制剂 神经信号通路(Neuronal Signaling) AChR 拮抗剂
• 发布时间：2018-05-20 08:00:00
• 更新时间：2024-01-02 12:02:38
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名称

• 中文名: 酒石酸托特罗
• 英文名: tolterodine tartrate
• 中文别名: 酒石酸托特罗
• 英文别名: (R)-2-(3-(DIISOPROPYLAMINO)-1-PHENYLPROPYL)-4-METHYLPHENOL 2,3-DIHYDROXYSUCCINATE; (R)-2-(3-DIISOPROPYLAMINO-1-PHENYL-PROPYL)-4-METHYL-PHENOL L-TARTRATE; 2-[(1R)-3-(dipropan-2-ylamino)-1-phenylpropyl]-4-methylphenol 2,3-dihydroxybutanedioate (1:1); MFCD07771985; (R)-2-(3-(Diisopropylamino)-1-phenylpropyl)-4-methylphenol (2R,3R)-2,3-dihydroxysuccinate; (+/-)-TOLTERODINE-D14 TARTRATE; TOLTERODINE; (+)-R)-2-{ALPHA-[2-(DIISOPROPYLAMINO)ETHYL]BENZYL}-P-CRESOL TARTRATE; (+)-R)-2-{A-[2-(DIISOPROPYLAMINO)ETHYL]BENZYL}-P-CRESOL TARTRATE; RIFABUTENE; Tolterodine L-Tartrate; TOLERODINE TARTRATE; Tolterodine tartrate; Butanedioic acid, 2,3-dihydroxy-, (2R,3R)-, compd. with 2-[(1R)-3-[bis(1-methylethyl)amino]-1-phenylpropyl]-4-methylphenol (1:1); TOLTERODINE TARTRATE, CERTIFIED REFERENCE MATERIAL; (2R,3R)-2,3-Dihydroxysuccinic acid - 2-[(1R)-3-(diisopropylamino)-1-phenylpropyl]-4-methylphenol (1:1); (R)-2-(3-Diisopropylamino-1-phenyl-propyl)-p-cresol L-tartrate; Tolterodine (Tartrate)

物化性质

• 密度: 1.003 g/cm3
• 沸点: 442.2ºC at 760 mmHg
• 熔点: 205-210ºC
• 分子式: C₂₆H₃₇NO₇
• 分子量: 475.574
• 闪点: 192.1ºC
• 精确质量: 475.256989
• PSA: 138.53000
• LogP: 3.21880
• 外观性状: 白色至灰白色结晶粉末
• 蒸汽压: 1.97E-08mmHg at 25°C
• 储存条件: Store at +4°C

生物活性

• 相关类别:
  信号通路 >> G 蛋白偶联受体/G 蛋白 >> 由mAChR
  信号通路 >> 神经信号通路 >> mAChR
  研究领域 >> 神经疾病
• 参考文献:

  [1]. Nilvebrant L. Tolterodine and its active 5-hydroxymethyl metabolite: pure muscarinic receptor antagonists. Pharmacol Toxicol. 2002 May;90(5):260-7.

  [2]. Andersson SH, et al. Biotransformation of tolterodine, a new muscarinic receptor antagonist, in mice, rats, and dogs. Drug Metab Dispos. 1998 Jun;26(6):528-35.

  [3]. Cappon GD, et al. Tolterodine does not affect memory assessed by passive-avoidance response test in mice. Eur J Pharmacol. 2008 Jan 28;579(1-3):225-8.

安全

• 符号: GHS06, GHS08
• 信号词: Danger
• 危害声明: H301-H361
• 警示性声明: Missing Phrase - N15.00950417-P280
• 危害码 (欧洲): Xi: Irritant;
• 风险声明 (欧洲): R20/21/22
• 安全声明 (欧洲): S36/37
• 危险品运输编码: NONH for all modes of transport
• 海关编码: 2922299090

合成路线

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海关

海关编码	2922299090
中文概述	2922299090. 其他氨基(萘酚、酚)及醚、酯〔包括它们的盐, 但含有一种以上含氧基的除外〕. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:30.0%
申报要素	品名, 成分含量, 用途, 乙醇胺及其盐应报明色度, 乙醇胺及其盐应报明包装
Summary	2922299090. other amino-naphthols and other amino-phenols, other than those containing more than one kind of oxygen function, their ethers and esters; salts thereof. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%