114084-78-5

• 常用中文名：伊班膦酸
• 常用英文名：ibandronic acid
• CAS号：114084-78-5
• 分子式：C₉H₂₃NO₇P₂
• 分子量：319.229
• 相关类别： 原料药 水、电解质及酸碱平衡调节药 电解质平衡调节药
• 发布时间：2018-03-28 08:00:00
• 更新时间：2024-01-04 19:47:39
• Ibandronic acid是高效含氮双磷酸盐,可作用于骨质疏松。

名称

• 中文名: 伊班膦酸
• 英文名: Ibandronate
• 中文别名: 3-(N-甲基-N-戊基)氨基-1-羟基丙烷-1,1-二膦酸; 伊班磷酸; 1-羟基-3-(甲基正戊胺基)-丙叉-1,1-双膦酸
• 英文别名: {1-Hydroxy-3-[methyl(pentyl)amino]propane-1,1-diyl}bis(phosphonic acid); Bondronat; [1-hydroxy-3-[methyl(pentyl)amino]-1-phosphonopropyl]phosphonic acid; ibandronic acid; Ibandronic acid [BAN:INN]; phosphonic acid, 1-hydroxy-3-(methylpentylamino)propylidenebis-; (1-Hydroxy-3-(methylpentylamino)propylidene)bisphosphonic acid; {1-Hydroxy-3-[methyl(pentyl)amino]-1,1-propanediyl}bis(phosphonic acid); {1-hydroxy-3-methyl(pentyl)aminopropane-1,1-diyl}bis(phosphonic acid); Phosphonic acid, [1-hydroxy-3-(methylpentylamino)propylidene]bis-; (1-Hydroxy-3-(methyl(pentyl)amino)propane-1,1-diyl)diphosphonic acid

物化性质

• 密度: 1.5±0.1 g/cm3
• 沸点: 587.8±60.0 °C at 760 mmHg
• 熔点: 113-115ºC
• 分子式: C₉H₂₃NO₇P₂
• 分子量: 319.229
• 闪点: 309.3±32.9 °C
• 精确质量: 319.094971
• PSA: 158.15000
• LogP: -0.65
• 外观性状: 白色半固体
• 蒸汽压: 0.0±3.7 mmHg at 25°C
• 折射率: 1.538
• 储存条件: -20°C Freezer

生物活性

• 描述: Ibandronic acid是高效含氮双磷酸盐,可作用于骨质疏松。
• 相关类别:
  信号通路 >> 其他 >> 其他
  研究领域 >> 其他
• 参考文献:

  [1]. Morgan, C., S. Jeremiah, and J. Wagstaff, Metronomic administration of ibandronate and its anti-angiogenic effects in vitro. Microvasc Res, 2009. 78(3): p. 453-8.

  [2]. Epplen, R., et al., Differential effects of ibandronate, docetaxel and farnesol treatment alone and in combination on the growth of prostate cancer cell lines. Acta Oncol, 2011. 50(1): p. 127-33.

  [3]. Chesnut, I.C., et al., Effects of oral ibandronate administered daily or intermittently on fracture risk in postmenopausal osteoporosis. J Bone Miner Res, 2004. 19(8): p. 1241-9.

  [4]. Bauss, F., et al., Effects of treatment with ibandronate on bone mass, architecture, biomechanical properties, and bone concentration of ibandronate in ovariectomized aged rats. J Rheumatol, 2002. 29(10): p. 2200-8.

安全

• 海关编码: 2931900090

合成路线

287395-61-3 ~6% 114084-78-5

文献：Journal of Medicinal Chemistry, , vol. 45, # 17 p. 3721 - 3738

上下游产品

上游产品  1
287395-61-3
下游产品  2
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海关

海关编码	2931900090
中文概述	2931900090. 其他有机-无机化合物. 增值税率:17.0%. 退税率:13.0%. 监管条件:AB(入境货物通关单,出境货物通关单). 最惠国关税:6.5%. 普通关税:30.0%
Summary	2931900090. other organo-inorganic compounds. VAT:17.0%. Tax rebate rate:13.0%. Supervision conditions:AB(certificate of inspection for goods inward,certificate of inspection for goods outward). MFN tariff:6.5%. General tariff:30.0%